Inflammation and innate immune activation in chronic HIV infection
Anthony Jaworowski and Anna C Hearps
+ Author Affiliations
- Author Affiliations
Burnet Institute
PO Box 2284
Melbourne, Vic. 3001, Australia
Tel: +61 3 9282 2127
Fax: +61 3 9282 2100
Email: anthonyj@burnet.edu.au
Microbiology Australia 35(2) 101-102 https://doi.org/10.1071/MA14032
Published: 16 April 2014
Abstract
Presently, there is no effective therapeutic HIV vaccine or a protective vaccine against de novo infection, and antiretroviral therapy is the only effective treatment for the many people currently infected with HIV. Current antiretroviral regimens, while effective at controlling HIV viremia, do not reduce inflammation and innate immune activation increased in chronically infected HIV+ individuals, who suffer increased prevalence of non-AIDS co-morbidities with an inflammatory aetiology. An understanding of the causes, and development of robust biomarkers, for innate immune activation is needed to improve health outcomes for the estimated 35 million HIV+ individuals.
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