Corynebacterium and Dolosigranulum: future probiotic candidates for upper respiratory tract infections
Rachael Lappan A B D and Christopher S Peacock A C
+ Author Affiliations
- Author Affiliations
A The Marshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia
B Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia
C Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia. Tel: +61 8 6457 6172, Email: Christopher.Peacock@uwa.edu.au
D Present address: The School of Biological Sciences, 18 Innovation Walk, Monash University, Clayton, Vic. 3800, Australia. Tel: +61 3 9905 5794, Email: Rachael.Lappan@monash.edu
Microbiology Australia 40(4) 172-177 https://doi.org/10.1071/MA19051
Published: 11 November 2019
Abstract
The presence of the bacterial genera Corynebacterium and Dolosigranulum has consistently been associated with a healthy upper respiratory tract (URT). Commonly occurring together in the nasopharynx of healthy children, the role of these commensal organisms in nasopharyngeal health is unknown, as few studies have sought to determine whether they actively contribute to maintaining a healthy state. We recently identified Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum as the major nasopharyngeal species associated with resistance to recurrent ear infections, via 16S rRNA gene sequencing and metagenomics. Using in vitro bacterial interference assays, we observed a reduction in the growth of Moraxella catarrhalis – one of the three major otopathogens – in the presence of C. pseudodiphtheriticum. Further in vitro and in vivo studies of the interactions between commensal C. pseudodiphtheriticum and D. pigrum strains, URT pathogens, and the human host will help to clarify their role in nasopharyngeal health. If they play a protective role, these organisms are promising candidates for the development of a probiotic therapy for the treatment or prevention of URT diseases in children.
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