Pathogen adaptation to vaccination: the Australian Bordetella pertussis story
Laurence Don Wai Luu
+ Author Affiliations
- Author Affiliations
School of Biotechnology and Biomolecular Sciences
University of New South Wales
Sydney, NSW, Australia
Tel: +61 2 9385 3063
Fax: +61 2 9385 1483
Email: laurence.luu@unsw.edu.au
Microbiology Australia 40(4) 177-180 https://doi.org/10.1071/MA19052
Published: 8 November 2019
Abstract
Whooping cough (pertussis) is a highly contagious vaccine preventable respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Despite high level vaccination coverage over the past 20 years, Australia has one of the highest per capita burdens of pertussis globally. One of the primary factors associated with the re-emergence of pertussis is pathogen adaptation of B. pertussis to the current acellular vaccines used. This article will focus on the genomic and proteomic changes that have occurred in the Australian B. pertussis population, the significance of these adaptive changes on fitness in a vaccinated environment and what we can do to reduce the significant burden of pertussis in the future.
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