Immune reconstitution disorders in HIV patients receiving antiretroviral therapy
Martyn A French
+ Author Affiliations
- Author Affiliations
School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
Department of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, WA, Australia
Email: martyn.french@uwa.edu.au
Microbiology Australia 35(2) 97-98 https://doi.org/10.1071/MA14030
Published: 16 April 2014
Abstract
Suppression of HIV infection by antiretroviral therapy (ART) resolves much of the immune dysfunction caused by HIV replication. However, reconstitution of the immune system during ART may, paradoxically, cause immunological disease that presents clinically as an immune reconstitution disorder. These disorders include autoimmune disease, mainly Graves' disease, and immune-mediated inflammatory disease, such as sarcoidosis. However, by far the most common type of immune reconstitution disorder results from restoring immune responses against opportunistic pathogens.
References
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