Sneezing leads to wheezing: microorganisms important in asthma
Christiana Willenborg A and Sacha Stelzer-Braid A BA Virology Division
SEALS Microbiology
Prince of Wales Hospital
Randwick, NSW 2031, Australia
Tel: +61 2 9382 9243
Email: Christiana.Willenborg@sesiahs.health.nsw.gov.au
B Virology Division
SEALS Microbiology
Prince of Wales Hospital
Randwick, NSW 2031, Australia
School of Medical Sciences
The University of New South Wales
Kensington, NSW 2033, Australia
Tel: +61 2 9382 9096
Fax: +61 2 9382 8533
Email: Sacha.Stelzer-Braid@sesiahs.health.nsw.gov.au
Microbiology Australia 34(3) 125-129 https://doi.org/10.1071/MA13042
Published: 4 September 2013
Abstract
Asthma is a chronic inflammatory condition of the airways. Microorganisms are the main cause of asthma exacerbations, with many cases of wheeze in children aged less than 1 year linked to asthma later in life. Respiratory viruses, particularly human rhinovirus, cause up to 90% of asthma exacerbations in children. In this review, we examine some of the viral, bacterial and fungal causes of asthma development and exacerbations.
References
[1] Edwards, M.R. et al. (2012) The microbiology of asthma. Nat. Rev. Microbiol. 10, 459–471.| 1:CAS:528:DC%2BC38XotVOrtbo%3D&md5=a166e8a884f870ae3be8175754f84299CAS | 22669219PubMed |
[2] Poulos, L.M. et al. (2005) The burden of asthma in children: an Australian perspective. Paediatr. Respir. Rev. 6, 20–27.
| The burden of asthma in children: an Australian perspective.Crossref | GoogleScholarGoogle Scholar | 15698810PubMed |
[3] Australian Institute of Health and Welfare 2013 http://www.aihw.gov.au/what-is-asthma/.
[4] Jackson, D.J. et al. (2011) Asthma exacerbations: origin, effect, and prevention. J. Allergy Clin. Immunol. 128, 1165–1174.
| Asthma exacerbations: origin, effect, and prevention.Crossref | GoogleScholarGoogle Scholar | 22133317PubMed |
[5] Australian Centre for Asthma Monitoring (2011) Asthma in Australia 2011. AIHW Asthma Series no. 4. Cat. no. ACM 22, Canberra, AIHW.
[6] Toelle, B.G. et al. (2004) Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross sectional surveys over 20 years. BMJ 328, 386–387.
| Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross sectional surveys over 20 years.Crossref | GoogleScholarGoogle Scholar | 14962876PubMed |
[7] Australian Institute of Health and Welfare: Australian Centre for Asthma Monitoring (2009) Burden of disease due to asthma in Australia 2003. Cat. no. ACM 16, Canberra, AIHW.
[8] Powell, H. and Gibson, P.G. (2003) Inhaled corticosteroid doses in asthma: an evidence-based approach. Med. J. Aust. 178, 223–225.
| 12603186PubMed |
[9] Daley, D. et al. (2012) Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J. Allergy Clin. Immunol. 130, 1284–1293.
| Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsVyht7fO&md5=a4d0ab1bc5c2a8efb264ed41f2269fa6CAS | 23063165PubMed |
[10] Çalışkan, M. et al. (2013) Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N. Engl. J. Med. 368, 1398–1407.
| Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.Crossref | GoogleScholarGoogle Scholar | 23534543PubMed |
[11] Jackson, D.J. et al. (2008) Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am. J. Respir. Crit. Care Med. 178, 667–672.
| Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.Crossref | GoogleScholarGoogle Scholar | 18565953PubMed |
[12] McErlean, P. et al. (2008) Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C). PLoS ONE 3, e1847.
| Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C).Crossref | GoogleScholarGoogle Scholar | 18382652PubMed |
[13] Gern, J.E. (2010) The ABCs of rhinoviruses, wheezing, and asthma. J. Virol. 84, 7418–7426.
| The ABCs of rhinoviruses, wheezing, and asthma.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVejtrbF&md5=232301f50a81689e74a3545722dd6308CAS | 20375160PubMed |
[14] Lee, W.M. et al. (2012) Human rhinovirus species and season of infection determine illness severity. Am. J. Respir. Crit. Care Med. 186, 886–891.
| Human rhinovirus species and season of infection determine illness severity.Crossref | GoogleScholarGoogle Scholar | 22923659PubMed |
[15] Arden, K.E. and Mackay, I.M. (2009) Human rhinoviruses: coming in from the cold. Genome Medicine 1, 44.
| Human rhinoviruses: coming in from the cold.Crossref | GoogleScholarGoogle Scholar | 19439028PubMed |
[16] Price, W.H. (1956) The isolation of a new virus associated with respiratory clinical disease in humans. Proc. Natl. Acad. Sci. USA 42, 892–896.
| The isolation of a new virus associated with respiratory clinical disease in humans.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD28zitFajsA%3D%3D&md5=5b822b97877d971c2c3ccf8bb9d5a16cCAS | 16589969PubMed |
[17] Pelon, W. et al. (1957) A cytopathogenic agent isolated from naval recruits with mild respiratory illnesses. Exp. Biol. Med. 94, 262.
| A cytopathogenic agent isolated from naval recruits with mild respiratory illnesses.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaG2s%2FlsVGisA%3D%3D&md5=162dab32256c7339cf0618972a43ae7cCAS |
[18] Lee, W.M. et al. (2007) A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS ONE 2, e966.
| A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants.Crossref | GoogleScholarGoogle Scholar | 17912345PubMed |
[19] Simmonds, P. et al. (2010) Proposals for the classification of human rhinovirus species C into genotypically assigned types. J. Gen. Virol. 91, 2409–2419.
| Proposals for the classification of human rhinovirus species C into genotypically assigned types.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht12qs73K&md5=d8c3da10df976f9af582e8c543feb03bCAS | 20610666PubMed |
[20] Bizzintino, J. et al. (2011) Association between human rhinovirus C and severity of acute asthma in children. Eur. Respir. J. 37, 1037–1042.
| Association between human rhinovirus C and severity of acute asthma in children.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3Mvmtlaitw%3D%3D&md5=b07b3e12072829c32a3b79bc36ece9e5CAS | 20693244PubMed |
[21] Miller, E.K. et al. (2009) A novel group of rhinoviruses is associated with asthma hospitalizations. J. Allergy Clin. Immunol. 123, 98–104.e101.
| A novel group of rhinoviruses is associated with asthma hospitalizations.Crossref | GoogleScholarGoogle Scholar |
[22] Linder, J.E. et al. (2013) Human rhinovirus C: age, season, and lower respiratory illness over the past 3 decades. J. Allergy Clin. Immunol. 131, 69–77.e1-6.
| Human rhinovirus C: age, season, and lower respiratory illness over the past 3 decades.Crossref | GoogleScholarGoogle Scholar | 23146382PubMed |
[23] Tovey, E.R. and Rawlinson, W.D. (2011) A modern miasma hypothesis and back-to-school asthma exacerbations. Med. Hypotheses 76, 113–116.
| A modern miasma hypothesis and back-to-school asthma exacerbations.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3M%2FltVWltQ%3D%3D&md5=69693c0f2d616f40cc65b76fde29bb1dCAS | 20869177PubMed |
[24] Lambert, S.B. et al. (2007) Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens. Pediatrics 120, e929–e937.
| Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens.Crossref | GoogleScholarGoogle Scholar | 17875651PubMed |
[25] Mackay, I.M. et al. (2013) Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period. J. Infect. Dis. 207, 1433–1441.
| Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period.Crossref | GoogleScholarGoogle Scholar | 22829638PubMed |
[26] Arden, K.E. et al. (2010) Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. J. Med. Virol. 82, 1458–1461.
| Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital.Crossref | GoogleScholarGoogle Scholar | 20572080PubMed |
[27] Papadopoulos, N.G. et al. (2011) Viruses and bacteria in acute asthma exacerbations--a GA(2) LEN-DARE systematic review. Allergy 66, 458–468.
| Viruses and bacteria in acute asthma exacerbations--a GA(2) LEN-DARE systematic review.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3Mrlt1ahsw%3D%3D&md5=4ee6bd5505f3f5384925d976d1aacc7fCAS | 21087215PubMed |
[28] Myles, P. et al. (2013) Differences between asthmatics and nonasthmatics hospitalised with influenza a infection. Eur. Respir. J. 41, 824–831.
| Differences between asthmatics and nonasthmatics hospitalised with influenza a infection.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXnt12rt78%3D&md5=a16f2fb95b25641195ac77aa6902a136CAS | 22903963PubMed |
[29] Rawlinson, W.D. et al. (2003) Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection. J. Infect. Dis. 187, 1314.
| Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection.Crossref | GoogleScholarGoogle Scholar | 12696012PubMed |
[30] García-García, M.L. et al. (2007) Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr. Pulmonol. 42, 458–464.
| Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5.Crossref | GoogleScholarGoogle Scholar | 17427899PubMed |
[31] Nissen, M.D. et al. (2002) Evidence of human metapneumovirus in Australian children. Med. J. Aust. 176, 188.
| 11913922PubMed |
[32] van den Hoogen, B.G. et al. (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat. Med. 7, 719–724.
| A newly discovered human pneumovirus isolated from young children with respiratory tract disease.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXnsVCqtbY%3D&md5=fd17c8867237425132438635d816e5d2CAS | 11385510PubMed |
[33] Papadopoulos, N.G. et al. (2011) Viruses and bacteria in acute asthma exacerbations – a GA2LEN-DARE* systematic review. Allergy 66, 458–468.
| Viruses and bacteria in acute asthma exacerbations – a GA2LEN-DARE* systematic review.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3Mrlt1ahsw%3D%3D&md5=4ee6bd5505f3f5384925d976d1aacc7fCAS | 21087215PubMed |
[34] Allander, T. et al. (2007) Human bocavirus and acute wheezing in children. Clin. Infect. Dis. 44, 904–910.
| Human bocavirus and acute wheezing in children.Crossref | GoogleScholarGoogle Scholar | 17342639PubMed |
[35] Sigurs, N. et al. (2010) Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 65, 1045–1052.
| Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life.Crossref | GoogleScholarGoogle Scholar | 20581410PubMed |
[36] Kusel, M.M.H. et al. (2012) Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze. Eur. Respir. J. 39, 876–882.
| Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC38zlvVWntw%3D%3D&md5=7e303b8a7b4b4984830ad2881e1fd907CAS |
[37] Kuehni, C.E. et al. (2009) Causal links between RSV infection and asthma: no clear answers to an old question. Am. J. Respir. Crit. Care Med. 179, 1079–1080.
| Causal links between RSV infection and asthma: no clear answers to an old question.Crossref | GoogleScholarGoogle Scholar | 19498062PubMed |
[38] Qasem, J.A. et al. (2013) Application of three uniplex polymerase chain reaction assays for the detection of atypical bacteria in asthmatic patients in Kuwait. J. Infect. Public Health 6, 134–141.
| Application of three uniplex polymerase chain reaction assays for the detection of atypical bacteria in asthmatic patients in Kuwait.Crossref | GoogleScholarGoogle Scholar | 23537827PubMed |
[39] Gil, J.C. et al. (1993) Isolation of mycoplasma pneumoniae from asthmatic patients. Ann. Allergy 70, 23–25.
| 1:STN:280:DyaK3s7ktlWitg%3D%3D&md5=e954b83aa49ef78d06fe77fd6d74da23CAS | 8424592PubMed |
[40] Biscardi, S. et al. (2004) Mycoplasma pneumoniae and asthma in children. Clin. Infect. Dis. 38, 1341–1346.
| Mycoplasma pneumoniae and asthma in children.Crossref | GoogleScholarGoogle Scholar | 15156467PubMed |
[41] Denning, D.W. et al. (2013) Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. Med. Mycol. 51, 361–370.
| Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.Crossref | GoogleScholarGoogle Scholar | 23210682PubMed |