Epstein–Barr virus-associated malignancies: pathobiology and emerging therapeutic options

Corey Smith; Rajiv Khanna

doi:10.1071/MA13041

RESEARCH ARTICLE

Previous Next Contents Vol 34(3)

Epstein–Barr virus-associated malignancies: pathobiology and emerging therapeutic options

Corey Smith and Rajiv Khanna

+ Author Affiliations

- Author Affiliations

Centre for Immunotherapy and Vaccine Development
Queensland Institute of Medical Research
Tumour Immunology Laboratory
Department of Immunology
300 Herston Road, Brisbane
Qld 4006, Australia
Tel: +61 7 3362 0385
Fax: +61 7 3845 3510
Email: rajiv.khanna@qimr.edu.au

Microbiology Australia 34(3) 120-124 https://doi.org/10.1071/MA13041
Published: 4 September 2013

Abstract

Epstein–Barr virus (EBV) was first identified in malignant Burkitt lymphoma cells in 1964. Since then, EBV has been associated with a number of other malignancies of either lymphocytic origin, including both B cell and NK/T cell cancers, or epithelial origin, predominantly nasopharyngeal and gastric cancers. While a complete understanding of the relationship between EBV-mediated cellular transformation and the oncogenic events that lead to uncontrolled malignant cell growth remains to be determined for a number of these cancers, it is clear in all of these settings that a breakdown in the immune surveillance of virally infected cells contributes to the survival of EBV-bearing malignant cells.

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