Quality use of antipsychotic medicines in residential aged care facilities in New Zealand
Henry C. Ndukwe 1 , Prasad S. Nishtala 1 , Ting Wang 2 , June M. Tordoff 11 School of Pharmacy, University of Otago, New Zealand
2 Department of Mathematics and Statistics, University of Otago, New Zealand
Correspondence to: Henry C. Ndukwe, School of Pharmacy, University of Otago, PO Box 56, Dunedin 9054, New Zealand. Email: henry.ndukwe@otago.ac.nz
Journal of Primary Health Care 8(4) 335-343 https://doi.org/10.1071/HC15054
Published: 21 December 2016
Journal Compilation © Royal New Zealand College of General Practitioners 2016.
This is an open access article licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Abstract
INTRODUCTION: Antipsychotic medicines are used regularly or when required in residential aged care facilities to treat symptoms of dementia, but have been associated with several adverse effects.
AIM: The aim of this study was to examine ‘quality use’ of antipsychotic medicines in residential aged care facilities in New Zealand, by surveying nurse managers.
METHODS: A cross-sectional survey was mailed to 318 nurse managers working in a nationally representative sample of aged care facilities. A purpose-developed, pre-tested, 22-item structured questionnaire was used to explore practice related to the quality use of antipsychotic medicines.
RESULTS: Overall, 31.4% of nurse managers responded to the survey. They mostly (88%) had ≥ 1 year’s relevant work experience and 83% of facilities provided care for those within the range of 21 to 100 residents. Respondents reported that staff education on dementia management occurred early in employment. Two-thirds of participants reported non-pharmacological interventions were commonly used for managing challenging behaviours, while less than half (45%) cited administering antipsychotic medicine. Respondents reported ‘managing behavioural symptoms’ (81%) as one of the main indications for antipsychotic use. Frequently identified adverse effects of antipsychotic medicines were drowsiness or sedation (64%) and falls (61%). Over 90% reported general practitioners reviewed antipsychotic use with respect to residents’ target behaviour 3-monthly, and two-thirds used an assessment tool to appraise residents’ behaviour.
DISCUSSION: Staff education on dementia management soon after employment and resident 3-monthly antipsychotic medicine reviews were positive findings. However, a wider use of behavioural assessment tools might improve the care of residents with dementia and the quality use of antipsychotic medicines.
KEYWORDS: Quality use; antipsychotic medicines; non-pharmacologic interventions; challenging behaviour; adverse effects; residential aged care facilities
References
[1] Kalapatapu RK, Schimming C. Update on neuropsychiatric symptoms of dementia: antipsychotic use. Geriatrics. 2009; 64 10–8.[2] Croucher M, Duncan C, Fisher M, et al. The use of antipsychotics in residential aged care: clinical recommendations developed by the RANZCP Faculty of Psychiatry of Old Age (New Zealand). Wellington, New Zealand: Best Practice Advocacy Centre; 2008.
[3] Kalapatapu RK, Neugroschl JA. Update on neuropsychiatric symptoms of dementia: evaluation and management. Geriatrics. 2009; 64 20–6.
[4] Best Practice Advocacy Centre Prescribing atypical antipsychotics in general practice. Best Practice Journal. 2011; 40 14–23.
[5] Jeste DV, Blazer D, Casey D, et al. ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008; 33 957–70.
| ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjtFOhtL4%3D&md5=5595a0e4e1f93fe5e765ab13cffc6574CAS |
[6] MEDSAFE (New Zealand Medicines and Medical Devices Safety Authority). Datasheet risperidone tablets: Risperidone 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 6 mg. Wellington: Medsafe; 2015.
[7] Hilmer SN, McLachlan AJ, Le Couteur DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007; 21 217–30.
| Clinical pharmacology in the geriatric patient.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmvValsrY%3D&md5=891fa36b2c4fb9d0e10f7b68e2d8a01aCAS |
[8] Muench J, Hamer AM. Adverse effects of antipsychotic medications. Am Fam Physician. 2010; 81 617–22.
[9] Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005; 294 1934–43.
| Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFCitLnK&md5=fee2b4915d4257d2566ac410e070c47fCAS |
[10] Nishtala PS, McLachlan AJ, Bell JS, Chen TF. Determinants of antipsychotic medication use among older people living in aged care homes in Australia. Int J Geriatr Psychiatry. 2010; 25 449–57.
| Determinants of antipsychotic medication use among older people living in aged care homes in Australia.Crossref | GoogleScholarGoogle Scholar |
[11] Tordoff JM, Ailabouni NJ, Browne DP, et al. Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand. Int J Clin Pharm. 2016; 38 941–9.
| Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC28XovFWhtLs%3D&md5=16c94d72a98b39b8ff3cf93ef865778cCAS |
[12] Ndukwe HC, Tordoff JM, Wang T, Nishtala PS. Psychotropic medicine utilization in older people in New Zealand from 2005 to 2013. Drugs Aging. 2014; 31 755–68.
| Psychotropic medicine utilization in older people in New Zealand from 2005 to 2013.Crossref | GoogleScholarGoogle Scholar |
[13] Ndukwe HC, Wang T, Tordoff JM, et al. Geographic variation in psychotropic drug utilisation among older people in New Zealand. Aust J Ageing. 2016;
| Geographic variation in psychotropic drug utilisation among older people in New Zealand.Crossref | GoogleScholarGoogle Scholar |
[14] Dellefield ME, Castle NG, McGilton KS, Spilsbury K. The relationship between registered nurses and nursing home quality: an integrative review (2008–2014). Nurs Econ. 2015; 33 95–116.
[15] Broad JB, Boyd M, Kerse N, et al. Residential aged care in Auckland, New Zealand 1988–2008: do real trends over time match predictions? Age Ageing. 2011; 40 487–94.
| Residential aged care in Auckland, New Zealand 1988–2008: do real trends over time match predictions?Crossref | GoogleScholarGoogle Scholar |
[16] Standards New Zealand (SNZ). Recovery. In: Health and Disability Services (Core) Standards. Wellington: Ministry of Health; 2008. p. 5–19.
[17] Standards New Zealand (SNZ). Health and Disability Services (Restraint Minimisation and Safe Practice) Standards. In: Restrain minimisation and safe practice. Wellington: Ministry of Health; 2008. p. 5–8.
[18] Ministry of Health. interRAI. HealthCERT Bulletin. Wellington: New Zealand Ministry of Health; 2015.
[19] New Zealand Legislation. Medicines regulations. Wellington: New Zealand Parliamentary Counsel Office; 1984.
[20] Standards New Zealand (SNZ). Health and disability services pharmacy services standard. In: Quality management. Wellington: Ministry of Health; 2010. p. 53–5.
[21] Department of Health. Quality Use of Medicines (QUM). Canberra: Australian Government, Department of Health. Updated 15 September 2011. [cited 2015 November 5] Available from: www.health.gov.au/internet/main/publishing.nsf/Content/nmp-quality.htm-copy2
[22] Best Practice Advocacy Centre Antipsychotics in dementia: Best Practice Guide. Best Practice Journal 2008; 2014 2–8. [cited 2015 May 2] Available from: www.bpac.org.nz/a4d/resources/docs/bpac_A4D_best_practice_guide.pdf
[23] Barback J. Advancing interRAI. In: Aged care & retirement - INsite. Wellington: NZME Educatioal Media NZ Ltd; 2013. p. 1–5.
[24] Dovey S, Loh LW, Cunningham WK. Leveraging information from New Zealand statistical data: a first step to wisdom in transforming unmet need for general practice services. N Z Med J. 2011; 124 15–7.
[25] ElderNet. New Zealand Directory of Residential Care. [cited 2015 February 2] Available from: www.eldernet.co.nz/Home
[26] Ministry of Health. Rest home certification and audits. [cited 2016 February 11]. Available from: www.health.govt.nz/your-health/services-and-support/health-care-services/services-older-people/rest-home-certification-and-audits
[27] Fowler FJ. Survey research methods, 4th edn. Thousand Oaks: Sage Publications; 2009.
[28] Marshall B, Clark J, Sheward K, Allan S. Staff perceptions of end-of-life care in aged residential care: a New Zealand perspective. J Palliat Med. 2011; 14 688–95.
| Staff perceptions of end-of-life care in aged residential care: a New Zealand perspective.Crossref | GoogleScholarGoogle Scholar |
[29] IBM Corp. IBM SPSS Statistics for Windows. Armonk, NY, USA: IBM Corp.; 2013.
[30] Brodaty H, Draper B, Low L-F. Nursing home staff attitudes towards residents with dementia: strain and satisfaction with work. J Adv Nurs. 2003; 44 583–90.
| Nursing home staff attitudes towards residents with dementia: strain and satisfaction with work.Crossref | GoogleScholarGoogle Scholar |
[31] Ministry of Health. New Zealand framework for dementia care. In: Principles of the framework. Wellington: Ministry of Health; 2013. p. 7–11.
[32] Ministry of Health. Standing order guidelines, 2nd edn. Wellington, New Zealand: Ministry of Health. updated 01 August 2016. [cited 2016 September 2]. Available from: www.health.govt.nz/system/files/documents/publications/standing-order-guidelines-aug16_0.pdf
[33] Backhouse T, Killett A, Penhale B, et al. Behavioural and psychological symptoms of dementia and their management in care homes within the East of England: a postal survey. Aging Ment Health. 2014; 18 187–93.
| Behavioural and psychological symptoms of dementia and their management in care homes within the East of England: a postal survey.Crossref | GoogleScholarGoogle Scholar |
[34] Glue P, Gale C. Off-label use of quetiapine in New Zealand—a cause for concern? N Z Med J. 2011; 124 10–3.
[35] Monasterio E, McKean A. Off-label use of atypical antipsychotic medications in Canterbury, New Zealand. N Z Med J. 2011; 124 24–9.
[36] Kamble P, Sherer J, Chen H, Aparasu R. Off-label use of second-generation antipsychotic agents among elderly nursing home residents. Psychiatr Serv. 2010; 61 130–6.
| Off-label use of second-generation antipsychotic agents among elderly nursing home residents.Crossref | GoogleScholarGoogle Scholar |
[37] Verhey FRJ, Verkaaik M, Lousberg R. Olanzapine versus haloperidol in the treatment of agitation in elderly patients with dementia: results of a randomized controlled double-blind trial. Dement Geriatr Cogn Disord. 2006; 21 1–8.
| Olanzapine versus haloperidol in the treatment of agitation in elderly patients with dementia: results of a randomized controlled double-blind trial.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtlWiurvL&md5=a28a3a63d421bd816ff3d7fc0af2f8d2CAS |
[38] Hope T, Pitt B. Management of dementia. In: Seminars in old age psychiatry. London: The Royal College of Psychiatrists; 1998. p. 87–101.
[39] Nishtala PS, Hilmer SN, McLachlan AJ, et al. Impact of residential medication management reviews on drug burden index in aged-care homes: a retrospective analysis. Drugs Aging. 2009; 26 677–86.
| Impact of residential medication management reviews on drug burden index in aged-care homes: a retrospective analysis.Crossref | GoogleScholarGoogle Scholar |
[40] Clark J, Marshall B, Sheward K, Allan S. Staff perceptions of the impact of the Liverpool Care Pathway in aged residential care in New Zealand. Int J Palliat Nurs. 2012; 18 171–8.
| Staff perceptions of the impact of the Liverpool Care Pathway in aged residential care in New Zealand.Crossref | GoogleScholarGoogle Scholar |
[41] Ruths S, Straand J, Nygaard HA. Multidisciplinary medication review in nursing home residents: what are the most significant drug-related problems? The Bergen District Nursing Home (BEDNURS) study. Qual Saf Health Care. 2003; 12 176–80.
| Multidisciplinary medication review in nursing home residents: what are the most significant drug-related problems? The Bergen District Nursing Home (BEDNURS) study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3s3ms1Whtw%3D%3D&md5=847816e6c287d0708d9284a46ae3e7baCAS |