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RESEARCH ARTICLE

Vascular stiffness and aging in HIV

William Chan A B and Anthony M. Dart A B C
+ Author Affiliations
- Author Affiliations

A Department of Cardiovascular Medicine, the Alfred Hospital, Melbourne, Vic. 3004, Australia.

B The Baker IDI Heart and Diabetes Institute, Melbourne, Vic. 3004, Australia.

C Corresponding author. Email: a.dart@alfred.org.au

Sexual Health 8(4) 474-484 https://doi.org/10.1071/SH10160
Submitted: 13 December 2010  Accepted: 31 March 2011   Published: 29 July 2011

Abstract

Large artery stiffening is a biological index of vascular aging. Vascular aging and atherosclerosis are two closely linked processes that develop in parallel and in synergy, sharing common aetiological determinants. Vascular stiffening increases left ventricular work and can lead to diminished coronary perfusion, and may therefore contribute to the development of cardiovascular disease. There is emerging evidence that large artery stiffness and vascular aging are accelerated in HIV infection because of the high prevalence of cardiovascular risk factors among HIV-infected patients. Moreover, the biological effects of HIV and the metabolic perturbations associated with antiretroviral therapies appear to accelerate vascular stiffening in HIV-infected patients. Further studies evaluating the effects of general and targeted therapies and various combinations of antiretroviral therapies on measures of large artery stiffness are urgently needed.

Additional keywords: AIDS, antiretroviral, carotid intima–media thickness, large artery stiffness, pulse wave velocity, vascular aging.


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