HIV, hepatitis viruses and viral STIs: intertwined fates?
Tony Cunningham
+ Author Affiliations
- Author Affiliations
Westmead Millennium Institute for Medical Research
Darcy Road
PO Box 412
Westmead, NSW 2145, Australia
Tel: +61 2 9845 9001
Fax: +61 2 9845 9100
Email: tony.cunningham@sydney.edu.au
Microbiology Australia 35(2) 83-87 https://doi.org/10.1071/MA14025
Published: 5 May 2014
Abstract
Although the major target cell for HIV in the body is the CD4 lymphocyte, uptake by and infection of other target cells such macrophages and dendritic cells also play a major role in pathogenesis. Macrophages are a major reservoir for HIV in most lymphoid tissue in the untreated patient and remain the major target cell in brain whether the subject is treated or not. Dendritic cells play a major role in transferring HIV efficiently to T cells particularly after viral entry through sexual transmission. Our work has focused on understanding how HIV binds to and enters these cells, trafficks through them and, during that time, alters their function to facilitate viral survival, replication and spread. Understanding of these processes is the foundation for a rational approach to the development of therapeutics (including microbicides) and vaccines.
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