Faecal microbiota transplantation: is it the future for pig production?
Tanya L Nowland A B and Roy N Kirkwood A
+ Author Affiliations
- Author Affiliations
A School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5400, Australia
B Tel.: +61 8 8313 7664, Email: tanya.nowland@adelaide.edu.au
Microbiology Australia 41(2) 91-94 https://doi.org/10.1071/MA20023
Published: 5 May 2020
Abstract
Piglet mortality is a major issue for the pork industry globally and until recently, the main method for improving growth performance and reducing disease in commercial practice is centred on anti-microbial use. Antibiotic resistance is a global concern and, as such, animal production industries are seeking alternatives to antibiotics. Different approaches under investigation include but are not limited to management of the intestinal microbial environment. The gastrointestinal microbiota is involved in a myriad of processes that impact host health and well-being. Recently, interest in maintaining a healthy microbiome in order to improve herd health is increasing. In this article, we focus on faecal microbiota transplantation as a method for manipulating and improving the gastrointestinal microbiota in pigs in order to improve health and performance.
References
[1] Daigle, C. (2018) Parallels between postpartum disorders in humans and preweaning piglet mortality in sows. Animals (Basel) 8, 22.| Parallels between postpartum disorders in humans and preweaning piglet mortality in sows.Crossref | GoogleScholarGoogle Scholar |
[2] Mota-Rojas, D. et al. (2012) Animal welfare in the newborn piglet: a review. Vet. Med. 57, 338–349.
| Animal welfare in the newborn piglet: a review.Crossref | GoogleScholarGoogle Scholar |
[3] Nuntapaitoon, M. et al. (2018) Newborn traits associated with pre-weaning growth and survival in piglets. Asian-Australas. J. Anim. Sci. 31, 237–244.
| Newborn traits associated with pre-weaning growth and survival in piglets.Crossref | GoogleScholarGoogle Scholar | 28728403PubMed |
[4] Roca, I. et al. (2015) The global threat of antimicrobial resistance: science for intervention. New Microbes New Infect. 6, 22–29.
| The global threat of antimicrobial resistance: science for intervention.Crossref | GoogleScholarGoogle Scholar | 26029375PubMed |
[5] Young, V.B. (2017) The role of the microbiome in human health and disease: an introduction for clinicians. BMJ 356, j831.
| The role of the microbiome in human health and disease: an introduction for clinicians.Crossref | GoogleScholarGoogle Scholar | 28298355PubMed |
[6] Abeles, S.R. and Pride, D.T. (2014) Molecular bases and role of viruses in the human microbiome. J. Mol. Biol. 426, 3892–3906.
| Molecular bases and role of viruses in the human microbiome.Crossref | GoogleScholarGoogle Scholar | 25020228PubMed |
[7] Hallen-Adams, H.E. and Suhr, M.J. (2017) Fungi in the healthy human gastrointestinal tract. Virulence 8, 352–358.
| Fungi in the healthy human gastrointestinal tract.Crossref | GoogleScholarGoogle Scholar | 27736307PubMed |
[8] Cahenzli, J. et al. (2013) Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 14, 559–570.
| Intestinal microbial diversity during early-life colonization shapes long-term IgE levels.Crossref | GoogleScholarGoogle Scholar | 24237701PubMed |
[9] Gensollen, T. et al. (2016) How colonization by microbiota in early life shapes the immune system. Science 352, 539–544.
| How colonization by microbiota in early life shapes the immune system.Crossref | GoogleScholarGoogle Scholar | 27126036PubMed |
[10] Wang, M. et al. (eds) (2016) Impact of early gut microbiota on immune and metabolic development and function. Seminars in Fetal and Neonatal Medicine.
[11] Looft, T. et al. (2014) Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations. ISME J. 8, 1566–1576.
| Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations.Crossref | GoogleScholarGoogle Scholar | 24522263PubMed |
[12] Brandt, L.J. and Aroniadis, O.C. (2013) An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest. Endosc. 78, 240–249.
| An overview of fecal microbiota transplantation: techniques, indications, and outcomes.Crossref | GoogleScholarGoogle Scholar | 23642791PubMed |
[13] Canibe, N. et al. (2019) Potential relevance of pig gut content transplantation for production and research. J. Anim. Sci. Biotechnol. 10, 55.
| Potential relevance of pig gut content transplantation for production and research.Crossref | GoogleScholarGoogle Scholar | 31304012PubMed |
[14] Bakken, J.S. et al. (2011) Treating clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol. Hepatol. 9, 1044–1049.
| Treating clostridium difficile infection with fecal microbiota transplantation.Crossref | GoogleScholarGoogle Scholar | 21871249PubMed |
[15] Cheng, C.S. et al. (2019) Early intervention with faecal microbiota transplantation: an effective means to improve growth performance and the intestinal development of suckling piglets. Animal 13, 533–541.
| Early intervention with faecal microbiota transplantation: an effective means to improve growth performance and the intestinal development of suckling piglets.Crossref | GoogleScholarGoogle Scholar | 29983136PubMed |
[16] Hu, L. et al. (2018) Exogenous fecal microbiota transplantation from local adult pigs to crossbred newborn piglets. Front. Microbiol. 8, 2663.
| Exogenous fecal microbiota transplantation from local adult pigs to crossbred newborn piglets.Crossref | GoogleScholarGoogle Scholar | 29375527PubMed |
[17] Xiao, Y. et al. (2017) Early gut microbiota intervention suppresses DSS-induced inflammatory responses by deactivating TLR/NLR signalling in pigs. Sci. Rep. 7, 3224.
| Early gut microbiota intervention suppresses DSS-induced inflammatory responses by deactivating TLR/NLR signalling in pigs.Crossref | GoogleScholarGoogle Scholar | 28607413PubMed |
[18] Hu, J. et al. (2018) A microbiota-derived bacteriocin targets the host to confer diarrhea resistance in early-weaned piglets. Cell Host Microbe 24, 817–832.e8.
| A microbiota-derived bacteriocin targets the host to confer diarrhea resistance in early-weaned piglets.Crossref | GoogleScholarGoogle Scholar | 30543777PubMed |
[19] McCormack, U.M. et al. (2018) Fecal microbiota transplantation in gestating sows and neonatal offspring alters lifetime intestinal microbiota and growth in offspring. mSystems 3, e00134-17.
| Fecal microbiota transplantation in gestating sows and neonatal offspring alters lifetime intestinal microbiota and growth in offspring.Crossref | GoogleScholarGoogle Scholar | 29577087PubMed |
[20] McCormack, U.M. et al. (2019) Improvement of feed efficiency in pigs through microbial modulation via fecal microbiota transplantation in sows and dietary supplementation of inulin in offspring. Appl. Environ. Microbiol. 85, e01255-19.
| Improvement of feed efficiency in pigs through microbial modulation via fecal microbiota transplantation in sows and dietary supplementation of inulin in offspring.Crossref | GoogleScholarGoogle Scholar | 31519656PubMed |
[21] Maruvada, P. et al. (2017) The human microbiome and obesity: moving beyond associations. Cell Host Microbe 22, 589–599.
| The human microbiome and obesity: moving beyond associations.Crossref | GoogleScholarGoogle Scholar | 29120742PubMed |
[22] Niederwerder, M.C. et al. (2018) Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease. Front. Microbiol. 9, 1631.
| Fecal microbiota transplantation is associated with reduced morbidity and mortality in porcine circovirus associated disease.Crossref | GoogleScholarGoogle Scholar | 30083142PubMed |
[23] Wan, J.J. et al. (2019) Effects of early intervention with maternal fecal bacteria and antibiotics on liver metabolome and transcription in neonatal pigs. Front. Physiol. 10, 171.
| Effects of early intervention with maternal fecal bacteria and antibiotics on liver metabolome and transcription in neonatal pigs.Crossref | GoogleScholarGoogle Scholar | 30890952PubMed |
[24] Brunse, A. et al. (2019) Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs. ISME J. 13, 720–733.
| Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs.Crossref | GoogleScholarGoogle Scholar | 30367124PubMed |
[25] Geng, S. et al. (2018) Faecal microbiota transplantation reduces susceptibility to epithelial injury and modulates tryptophan metabolism of the microbial community in a piglet model. J. Crohns Colitis 12, 1359–1374.
| Faecal microbiota transplantation reduces susceptibility to epithelial injury and modulates tryptophan metabolism of the microbial community in a piglet model.Crossref | GoogleScholarGoogle Scholar | 30010734PubMed |
