Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa
Dinesh Subedi A , Ajay Kumar Vijay B , Scott A Rice C and Mark Willcox D
+ Author Affiliations
- Author Affiliations
A School of Optometry and Vision Science, UNSW Sydney, NSW 2052, Australia. Tel: +61 4 1397 3921, Fax: +61 2 9313 6243, Email: d.subedi@unsw.edu.au, subedi.dnes@gmail.com
B School of Optometry and Vision Science, UNSW Sydney, NSW 2052, Australia. Tel: +61 2 9385 4503, Fax: +61 2 9313 6243, Email: v.ajaykumar@unsw.edu.au
C School of Biological Sciences, NTU. Tel: +65 6592 7944, Office: SBS B1N 27, Email: rscott@ntu.edu.sg
D School of Optometry and Vision Science, UNSW Sydney, NSW 2052, Australia. Tel: +61 2 9385 4164, Email: m.willcox@unsw.edu.au
Microbiology Australia 40(4) 161-164 https://doi.org/10.1071/MA19048
Published: 29 October 2019
Abstract
The Gram-negative opportunistic bacterium Pseudomonas aeruginosa is associated with different types of human infections and because of emerging multidrug-resistant strains, these infections are of major global public health concern. Certain strains possess a unique cytotoxic effector protein ExoU, which contributes to the fitness of this organism in different ecological niches and is associated with acquired antibiotic resistance. This article summarises the current knowledge of the exoU gene in P. aeruginosa, including genetics, distribution in strains from different locations and association with antibiotic resistance. Understanding of this effector protein may have important implications for the understanding of pathogenesis and antimicrobial resistance in P. aeruginosa infections.
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