Clostridium perfringens extracellular toxins and enzymes: 20 and counting
Sarah A Revitt-Mills A , Julian I Rood A and Vicki Adams A B
+ Author Affiliations
- Author Affiliations
A Monash University
19 Innovation Drive
Clayton, Vic. 3800, Australia
Tel: +61 3 9902 9139
Fax: +61 3 9902 2222
B Email: vicki.adams@monash.edu
Microbiology Australia 36(3) 114-117 https://doi.org/10.1071/MA15039
Published: 14 August 2015
Abstract
Clostridium perfringens is a Gram-positive, anaerobic bacterium that is widely distributed in the environment; it is found in soil and commonly inhabits the gastrointestinal tract of humans and animals1,2. The ubiquitous nature of this bacterium has resulted in it becoming a major cause of histotoxic and enteric diseases3. The success of C. perfringens as both a pathogen and a commensal bacterium lies in its ability to produce a large number of potent toxins and extracellular enzymes4. This diverse toxin repertoire results in a broad range of diseases including gas gangrene, various enterotoxaemias, food poisoning and necrotic enteritis4–6. Since 2007, six new toxins have been identified, adding to the ever-increasing range of potential
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