Measles and SSPE: occurrence and pathogenesis
Jude Jayamaha
+ Author Affiliations
- Author Affiliations
Department of Virology
Medical Research Institute
PO Box 527
Colombo 008, Sri Lanka
Email: jayamahacar@gmail.com
Microbiology Australia 34(3) 132-134 https://doi.org/10.1071/MA13044
Published: 4 September 2013
Abstract
Measles is an acute febrile exanthematous condition that is usually a self-limiting disease, but it can be associated with several complications, one of which is subacute sclerosing panencephalitis (SSPE). It is a rare delayed complication of measles due to persistence of the virus in the central nervous system. All of the genetic analyses of viral material derived from brain tissue of SSPE patients have revealed sequences of wild-type measles virus (MV). There is no evidence that measles vaccine can cause SSPE. Several mutations have been described in genes coding for proteins in SSPE strains of MV. Several host cell modifications, mechanisms of virus reactivation and immunopathology in pathogenesis of SSPE have been explained recently, broadening the understanding of this fatal disease.
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