Emeritus Professor Derek Ashworth Denton (1924–2022)

Michael J. McKinley

doi:10.1071/HR24029

EDITORIAL (Open Access)

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Emeritus Professor Derek Ashworth Denton (1924–2022)

Michael J. McKinley

^A ^B ^*

+ Author Affiliations

- Author Affiliations

^A Florey Institute of Neurosciences and Mental Health, University of Melbourne, Parkville, Vic 3052, Australia.

^B Department of Anatomy and Physiology, University of Melbourne, Parkville, Vic 3052, Australia.

^* Correspondence to: michael.mckinley@unimelb.edu.au

Historical Records of Australian Science 36, HR24029 https://doi.org/10.1071/HR24029

Published online: 17 March 2025

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing on behalf of the Australian Academy of Science. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)

Abstract

Derek Denton was born on 27 May 1924 in Launceston and educated at Launceston Grammar School. He studied medicine at the University of Melbourne, graduating in 1947. During his residency at Royal Melbourne Hospital he cared for critically ill post-operative patients. This experience stimulated him to question accepted medical wisdom, leading to a lifelong quest to understand physiological mechanisms regulating body fluid and electrolyte homeostasis. He joined the University of Melbourne’s Department of Physiology in 1949. There, together with Dr Victor Wynn, he initiated the Ionic Research Unit, investigating renal mechanisms regulating sodium and water balance, and began a mobile emergency service working across Melbourne hospitals to rapidly assess, and provide, fluid and electrolyte therapy for patients with life-threatening conditions. In 1951, Denton moved to Cambridge, working with Professor E. Basil Verney to develop expertise in large animal physiology. While in Cambridge, he married Margaret Scott, a leading ballet dancer. On returning to the Ionic Research Unit in 1953, he elucidated many aspects of the physiological regulation of bodily sodium and potassium balance utilising sheep with a chronic parotid fistula to induce sodium depletion, and sheep with transplanted adrenal gland to make groundbreaking discoveries regarding the physiological regulation of the salt-retaining hormone aldosterone. He also pioneered studies of salt appetite. In the early 1960s, Denton played an important role in establishing the Howard Florey Laboratories in the University of Melbourne, and was appointed the first Director of the Howard Florey Institute of Experimental Physiology and Medicine in 1971, retiring from this position in 1989. He continued experimental work during the next thirty years, focusing on brain function and instinctual behaviour. Derek Denton was elected FAA in 1979, FRS in 1989 and made a Companion of the Order of Australia in 2005. He died at his home on 18 November 2022.

Keywords: aldosterone, brain function, Derek Denton, fluid and electrolytes, Howard Florey Institute, hypertension, instinctual behaviour, physiology, salt intake, University of Melbourne.

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