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RESEARCH ARTICLE
Contents Vol 70(3)

Polymeric Nanofibre Scaffold for the Delivery of a Transforming Growth Factor β1 Inhibitor

Vipul Agarwal A , Fiona M. Wood B C , Mark Fear C and K. Swaminathan Iyer A D
+ Author Affiliations
- Author Affiliations

A School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.

B Burns Service Western Australia, Department of Health, Perth, WA 6009, Australia.

C Burn Injury Research Unit, School of Surgery, The University of Western Australia, Crawley, WA 6009, Australia.

D Corresponding author. Email: swaminatha.iyer@uwa.edu.au

Australian Journal of Chemistry 70(3) 280-285 https://doi.org/10.1071/CH16332
Submitted: 29 May 2016  Accepted: 9 August 2016   Published: 14 September 2016

Abstract

Skin scarring is a highly prevalent and inevitable outcome of adult mammalian wound healing. Scar tissue is both pathologically and aesthetically inferior to the normal skin owing to elevated concentration of highly orientated collagen I architecture in the innate repaired tissue. With highly invasive surgery being the main treatment modality, there is a great need for alternative strategies to mitigate the problem of scar formation. Tissue engineering approaches using polymeric scaffolds have shown tremendous promise in various disease models including skin wound healing; however, the problem of skin scarring has been greatly overlooked. Herein, we developed an electrospun poly(glycidyl methacrylate) (ES-PGMA) scaffold incorporating a small-molecule antiscarring agent, PXS64. PXS64, a lipophilic neutral analogue of mannose-6-phosphate, has been shown to inhibit the activation of transforming growth factor β1 (TGFβ1). TGFβ1 is a primary protein cytokine regulating the expression of collagen I during wound healing and therefore governs the formation of scar tissue. The nanofibres were tested for biocompatibility as a tissue engineering scaffold and for their efficacy to inhibit TGFβ1 activation in human dermal skin fibroblasts.


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