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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
REVIEW

Advances in high abundance protein molecular imprinting techniques in human serum

Zhipeng Liu A , Aijun Gong https://orcid.org/0000-0002-6261-1013 A B * , Lina Qiu A B , Yang Liu A , Shujia Zheng A , Wenyan Qin C and RongRong Fan D
+ Author Affiliations
- Author Affiliations

A College of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.

B Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, University of Science and Technology Beijing, Beijing, 100083, China.

C CapitalBio Technology Inc., Beijing, 101111, China.

D Kunshan Hexin Mass Spectrometry Technology Co, Ltd, Kunshan,Jiangsu, 215300, China.

* Correspondence to: Gongaijun5661@ustb.edu.cn

Handling Editor: Charlotte Williams

Australian Journal of Chemistry 76(3) 150-168 https://doi.org/10.1071/CH22223
Submitted: 18 October 2022  Accepted: 30 March 2023   Published: 8 May 2023

© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing.

Abstract

The detection of protein biomarkers is crucial for early disease diagnosis. However, these biomarkers are present at low levels in serum, and the detection signal is easily interfered with by high levels of proteins. These factors pose major challenges for direct biomarker detection by existing technologies; thus, sample pre-treatments are performed as the best solution. Molecularly imprinted polymers have excellent properties of good binding ability, high selectivity and low cost, making this technique one of the best for serum pre-treatment. This review discusses the recent research status and development of bulk and surface imprinting techniques for high-abundance proteins. Furthermore, this paper emphasizes the research overview and progress of substrate and template selection, template immobilization technology and strategies to control the thickness of imprinted polymers when using the surface imprinting technique. Finally, the main challenges of molecular imprinting technique (MIT) application for high-abundance proteins and the future direction of this field are highlighted.

Keywords: epitope imprinting, high abundance protein, metal chelation, MIP, MIT, molecular gels, oriented immobilization, specific identification, surface imprinting.


References

[1]  Arshavsky-Graham S, Segal E. Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics. In: Bahnemann J, Grünberger A, editors. Advances in biochemical engineering/biotechnology. Vol. 179. Cham: Springer; 2022. pp. 247–265.

[2]  S-M Yang, S Lv, W Zhang, et al. Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges. Sensors 2022, 22, 1620.
         | Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges.Crossref | GoogleScholarGoogle Scholar |

[3]  M Stauss, B Keevil, A Woywodt, Point-of-Care Testing: Home Is Where the Lab Is. Kidney360 2022, 3, 1285.
         | Point-of-Care Testing: Home Is Where the Lab Is.Crossref | GoogleScholarGoogle Scholar |

[4]  S Shrivastava, TQ Trung, N-E Lee, Recent Progress, Challenges, and Prospects of Fully Integrated Mobile and Wearable Point-of-Care Testing Systems for Self-testing. Chem Soc Rev 2020, 49, 1812.
         | Recent Progress, Challenges, and Prospects of Fully Integrated Mobile and Wearable Point-of-Care Testing Systems for Self-testing.Crossref | GoogleScholarGoogle Scholar |

[5]  H Chen, K Liu, Z Li, P Wang, Point of Care Testing for Infectious Diseases. Clin Chim Acta 2019, 493, 138.
         | Point of Care Testing for Infectious Diseases.Crossref | GoogleScholarGoogle Scholar |

[6]  NT Darwish, SD Sekaran, SM Khor, Point-of-care tests: A review of advances in the emerging diagnostic tools for dengue virus infection. Sens Actuators B Chem 2018, 255, 3316.
         | Point-of-care tests: A review of advances in the emerging diagnostic tools for dengue virus infection.Crossref | GoogleScholarGoogle Scholar |

[7]  S Liu, W Ji, J Lu, et al. Discovery of Potential Serum Protein Biomarkers in Ankylosing Spondylitis Using Tandem Mass Tag-Based Quantitative Proteomics. J Proteome Res 2020, 19, 864.
         | Discovery of Potential Serum Protein Biomarkers in Ankylosing Spondylitis Using Tandem Mass Tag-Based Quantitative Proteomics.Crossref | GoogleScholarGoogle Scholar |

[8]  AL Comes, S Papiol, T Mueller, et al. Proteomics for Blood Biomarker Exploration of Severe Mental Illness: Pitfalls of the Past and Potential for the Future. Transl Psychiatry 2018, 8, 160.
         | Proteomics for Blood Biomarker Exploration of Severe Mental Illness: Pitfalls of the Past and Potential for the Future.Crossref | GoogleScholarGoogle Scholar |

[9]  K Duangkumpha, T Stoll, J Phetcharaburanin, et al. Urine Proteomics Study Reveals Potential Biomarkers for the Differential Diagnosis of Cholangiocarcinoma and Periductal Fibrosis. PLoS One 2019, 14, e0221024.
         | Urine Proteomics Study Reveals Potential Biomarkers for the Differential Diagnosis of Cholangiocarcinoma and Periductal Fibrosis.Crossref | GoogleScholarGoogle Scholar |

[10]  RB Gil, OE Akingbade, X Guo, et al. Multiplexed immunosensors for point-of-care diagnostic applications. Biosens Bioelectron 2022, 203, 114050.
         | Multiplexed immunosensors for point-of-care diagnostic applications.Crossref | GoogleScholarGoogle Scholar |

[11]  Y Song, Y-Y Huang, X Liu, et al. Point-of-Care Technologies for Molecular Diagnostics Using a Drop of Blood. Trends Biotechnol 2014, 32, 132.
         | Point-of-Care Technologies for Molecular Diagnostics Using a Drop of Blood.Crossref | GoogleScholarGoogle Scholar |

[12]  P Feist, AB Hummon, Proteomic Challenges: Sample Preparation Techniques for Microgram-Quantity Protein Analysis from Biological Samples. Int J Mol Sci 2015, 16, 3537.
         | Proteomic Challenges: Sample Preparation Techniques for Microgram-Quantity Protein Analysis from Biological Samples.Crossref | GoogleScholarGoogle Scholar |

[13]  A Halim, U Rüetschi, G Larson, J Nilsson, LC−MS/MS Characterization of O-Glycosylation Sites and Glycan Structures of Human Cerebrospinal Fluid Glycoproteins. J Proteome Res 2013, 12, 573.
         | LC−MS/MS Characterization of O-Glycosylation Sites and Glycan Structures of Human Cerebrospinal Fluid Glycoproteins.Crossref | GoogleScholarGoogle Scholar |

[14]  JB Shaw, W Li, DD Holden, et al. Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation. J Am Chem Soc 2013, 135, 12646.
         | Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation.Crossref | GoogleScholarGoogle Scholar |

[15]  S Chen, L Zhang, Q Yuan, et al. Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation. Chem Res Chin Univ 2022, 38, 847.
         | Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation.Crossref | GoogleScholarGoogle Scholar |

[16]  K Haupt, Peer Reviewed: Molecularly Imprinted Polymers: The Next Generation. Anal Chem 2003, 75, 376 A.
         | Peer Reviewed: Molecularly Imprinted Polymers: The Next Generation.Crossref | GoogleScholarGoogle Scholar |

[17]  M Cieplak, W Kutner, Artificial Biosensors: How Can Molecular Imprinting Mimic Biorecognition? Trends Biotechnol 2016, 34, 922.
         | Artificial Biosensors: How Can Molecular Imprinting Mimic Biorecognition?Crossref | GoogleScholarGoogle Scholar |

[18]  Z Iskierko, PS Sharma, K Bartold, et al. Molecularly imprinted polymers for separating and sensing of macromolecular compounds and microorganisms. Biotechnol Adv 2016, 34, 30.
         | Molecularly imprinted polymers for separating and sensing of macromolecular compounds and microorganisms.Crossref | GoogleScholarGoogle Scholar |

[19]  JJ BelBruno, Molecularly Imprinted Polymers. Chem Rev 2019, 119, 94.
         | Molecularly Imprinted Polymers.Crossref | GoogleScholarGoogle Scholar |

[20]  K Haupt, K Mosbach, Molecularly Imprinted Polymers and Their Use in Biomimetic Sensors. Chem Rev 2000, 100, 2495.
         | Molecularly Imprinted Polymers and Their Use in Biomimetic Sensors.Crossref | GoogleScholarGoogle Scholar |

[21]  K Haupt, PX Medina Rangel, BTS Bui, Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy. Chem Rev 2020, 120, 9554.
         | Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy.Crossref | GoogleScholarGoogle Scholar |

[22]  X Wang, G Chen, P Zhang, et al. Advances in epitope molecularly imprinted polymers for protein detection: a review. Anal Methods 2021, 13, 1660.
         | Advances in epitope molecularly imprinted polymers for protein detection: a review.Crossref | GoogleScholarGoogle Scholar |

[23]  G Wulff, M Lauer, H Böhnke, Rapid Proton Transfer as Cause of an Unusually Large Neighboring Group Effect. Angew Chem Int Ed Engl 1984, 23, 741.
         | Rapid Proton Transfer as Cause of an Unusually Large Neighboring Group Effect.Crossref | GoogleScholarGoogle Scholar |

[24]  L Chen, S Xu, J Li, Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. Chem Soc Rev 2011, 40, 2922.
         | Recent advances in molecular imprinting technology: current status, challenges and highlighted applications.Crossref | GoogleScholarGoogle Scholar |

[25]  M Werner, MS Glück, B Bräuer, et al. Investigations on sub-structures within cavities of surface imprinted polymers using AFM and PF-QNM. Soft Matter 2022, 18, 2245.
         |  Investigations on sub-structures within cavities of surface imprinted polymers using AFM and PF-QNM.Crossref | GoogleScholarGoogle Scholar |

[26]  GK Ali, KM Omer, Molecular imprinted polymer combined with aptamer (MIP-aptamer) as a hybrid dual recognition element for bio(chemical) sensing applications. Review. Talanta 2022, 236, 122878.
         | Molecular imprinted polymer combined with aptamer (MIP-aptamer) as a hybrid dual recognition element for bio(chemical) sensing applications. Review.Crossref | GoogleScholarGoogle Scholar |

[27]  N Tarannum, OD Hendrickson, S Khatoon, et al. Molecularly imprinted polymers as receptors for assays of antibiotics. Crit Rev Anal Chem 2020, 50, 291.
         | Molecularly imprinted polymers as receptors for assays of antibiotics.Crossref | GoogleScholarGoogle Scholar |

[28]  L Cenci, C Piotto, P Bettotti, et al. Study on molecularly imprinted nanoparticle modified microplates for pseudo-ELISA assays. Talanta 2018, 178, 772.
         | Study on molecularly imprinted nanoparticle modified microplates for pseudo-ELISA assays.Crossref | GoogleScholarGoogle Scholar |

[29]  MJ Whitcombe, I Chianella, L Larcombe, et al. The rational development of molecularly imprinted polymer-based sensors for protein detection. Chem Soc Rev 2011, 40, 1547.
         | The rational development of molecularly imprinted polymer-based sensors for protein detection.Crossref | GoogleScholarGoogle Scholar |

[30]  MR Baezzat, M Bagheri, E Abdollahi, Molecularly imprinted polymer based sensor for measuring of zileuton: Evaluation as a modifier for carbon paste electrode in electrochemically recognition. Mater Today Commun 2019, 19, 23.
         | Molecularly imprinted polymer based sensor for measuring of zileuton: Evaluation as a modifier for carbon paste electrode in electrochemically recognition.Crossref | GoogleScholarGoogle Scholar |

[31]  A Kumar Singh, M Singh, QCM sensing of melphalan via electropolymerized molecularly imprinted polythiophene films. Biosens Bioelectron 2015, 74, 711.
         | QCM sensing of melphalan via electropolymerized molecularly imprinted polythiophene films.Crossref | GoogleScholarGoogle Scholar |

[32]  Y Lv, Y Qin, F Svec, Molecularly imprinted plasmonic nanosensor for selective SERS detection of protein biomarkers. Biosens Bioelectron 2016, 80, 433.
         | Molecularly imprinted plasmonic nanosensor for selective SERS detection of protein biomarkers.Crossref | GoogleScholarGoogle Scholar |

[33]  X Song, J Li, J Wang, L Chen, Quercetin molecularly imprinted polymers: Preparation, recognition characteristics and properties as sorbent for solid-phase extraction. Talanta 2009, 80, 694.
         | Quercetin molecularly imprinted polymers: Preparation, recognition characteristics and properties as sorbent for solid-phase extraction.Crossref | GoogleScholarGoogle Scholar |

[34]  B Rezaei, S Mallakpour, N Majidi, Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum. Talanta 2009, 78, 418.
         | Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum.Crossref | GoogleScholarGoogle Scholar |

[35]  T Jiang, L Zhao, B Chua, et al. Molecularly imprinted solid-phase extraction for the selective determination of 17β-estradiol in fishery samples with high performance liquid chromatography. Talanta 2009, 78, 442.
         | Molecularly imprinted solid-phase extraction for the selective determination of 17β-estradiol in fishery samples with high performance liquid chromatography.Crossref | GoogleScholarGoogle Scholar |

[36]  O Núñez, H Gallart-Ayala, PB Martins, et al. New trends in fast liquid chromatography for food and environmental analysis. J Chromatogr A 2012, 1228, 298.
         | New trends in fast liquid chromatography for food and environmental analysis.Crossref | GoogleScholarGoogle Scholar |

[37]  J Pu, H Wang, C Huang, C Bo, B Gong, J Ou, Progress of molecular imprinting technique for enantioseparation of chiral drugs in recent ten years. J Chromatogr A 2022, 1668, 462914.
         | Progress of molecular imprinting technique for enantioseparation of chiral drugs in recent ten years.Crossref | GoogleScholarGoogle Scholar |

[38]  LM Madikizela, PN Nomngongo, VE Pakade, Synthesis of molecularly imprinted polymers for extraction of fluoroquinolones in environmental, food and biological samples. J Pharm Biomed Anal 2022, 208, 114447.
         | Synthesis of molecularly imprinted polymers for extraction of fluoroquinolones in environmental, food and biological samples.Crossref | GoogleScholarGoogle Scholar |

[39]  J Kopeček, Swell Gels. Nature 2002, 417, 389.
         | Swell Gels.Crossref | GoogleScholarGoogle Scholar |

[40]  S Xu, H Lu, X Zheng, L Chen, Stimuli-responsive Molecularly Imprinted Polymers: Versatile Functional Materials. J Mater Chem C 2013, 1, 4406.
         | Stimuli-responsive Molecularly Imprinted Polymers: Versatile Functional Materials.Crossref | GoogleScholarGoogle Scholar |

[41]  M Andac, IY Galaev, A Denizli, Molecularly imprinted poly(hydroxyethyl methacrylate) based cryogel for albumin depletion from human serum. Colloids Surf B Biointerfaces 2013, 109, 259.
         | Molecularly imprinted poly(hydroxyethyl methacrylate) based cryogel for albumin depletion from human serum.Crossref | GoogleScholarGoogle Scholar |

[42]  T Morishita, A Yoshida, H Hayakawa, et al. Molecularly Imprinted Nanogels Possessing Dansylamide Interaction Sites for Controlling Protein Corona In Situ by Cloaking Intrinsic Human Serum Albumin. Langmuir 2020, 36, 10674.
         | Molecularly Imprinted Nanogels Possessing Dansylamide Interaction Sites for Controlling Protein Corona In Situ by Cloaking Intrinsic Human Serum Albumin.Crossref | GoogleScholarGoogle Scholar |

[43]  K Yang, S Li, L Jianxi, et al. Multiepitope Templates Imprinted Particles for the Simultaneous Capture of Various Target Proteins. Anal Chem 2016, 88, 5621.
         | Multiepitope Templates Imprinted Particles for the Simultaneous Capture of Various Target Proteins.Crossref | GoogleScholarGoogle Scholar |

[44]  I Perçin, N Idil, A Denizli, Molecularly imprinted poly(N-isopropylacrylamide) thermosensitive based cryogel for immunoglobulin G purification. Process Biochem 2019, 80, 181.
         | Molecularly imprinted poly(N-isopropylacrylamide) thermosensitive based cryogel for immunoglobulin G purification.Crossref | GoogleScholarGoogle Scholar |

[45]  S Li, S Cao, MJ Whitcombe, SA Piletsky, Size Matters: Challenges in Imprinting Macromolecules. Prog Polym Sci 2014, 39, 145.
         | Size Matters: Challenges in Imprinting Macromolecules.Crossref | GoogleScholarGoogle Scholar |

[46]  E Verheyen, JP Schillemans, M van Wijk, et al. Challenges for the Effective Molecular Imprinting of Proteins. Biomaterials 2011, 32, 3008.
         | Challenges for the Effective Molecular Imprinting of Proteins.Crossref | GoogleScholarGoogle Scholar |

[47]  NW Turner, CW Jeans, KR Brain, et al. From 3D to 2D: A Review of the Molecular Imprinting of Proteins. Biotechnol Prog 2006, 22, 1474.
         | From 3D to 2D: A Review of the Molecular Imprinting of Proteins.Crossref | GoogleScholarGoogle Scholar |

[48]  S Schwark, W Sun, J Stute, et al. Monoclonal Antibody Capture from Cell Culture Supernatants using Epitope Imprinted Macroporous Membranes. RSC Adv 2016, 6, 53162.
         | Monoclonal Antibody Capture from Cell Culture Supernatants using Epitope Imprinted Macroporous Membranes.Crossref | GoogleScholarGoogle Scholar |

[49]  D Yin, M Ulbricht, Protein-selective Adsorbers by Molecular Imprinting via a Novel two-step Surface Grafting Method. J Mater Chem B 2013, 1, 3209.
         | Protein-selective Adsorbers by Molecular Imprinting via a Novel two-step Surface Grafting Method.Crossref | GoogleScholarGoogle Scholar |

[50]  Y Lv, T Tan, F Svec, Molecular Imprinting of Proteins in Polymers Attached to the Surface of Nanomaterials for Selective Recognition of Biomacromolecules. Biotechnol Adv 2013, 31, 1172.
         | Molecular Imprinting of Proteins in Polymers Attached to the Surface of Nanomaterials for Selective Recognition of Biomacromolecules.Crossref | GoogleScholarGoogle Scholar |

[51]  FTC Moreira, S Sharma, RAF Dutra, et al. Protein-Responsive Polymers for Point-of-Care Detection of Cardiac Biomarker. Sens Actuators B Chem 2014, 196, 123.
         | Protein-Responsive Polymers for Point-of-Care Detection of Cardiac Biomarker.Crossref | GoogleScholarGoogle Scholar |

[52]  J Erdőssy, V Horváth, A Yarman, et al. Electrosynthesized Molecularly Imprinted Polymers for Protein Recognition. TrAC Trends Anal Chem 2016, 79, 179.
         | Electrosynthesized Molecularly Imprinted Polymers for Protein Recognition.Crossref | GoogleScholarGoogle Scholar |

[53]  H Shi, WB Tsai, MD Garrison, et al. Template-imprinted nanostructured surfaces for protein recognition. Nature 1999, 398, 593.
         | Template-imprinted nanostructured surfaces for protein recognition.Crossref | GoogleScholarGoogle Scholar |

[54]  E Yilmaz, K Haupt, K Mosbach, The use of immobilized templates -a new approach in molecular imprinting. Angew Chem Int Ed 2000, 39, 2115.
         | The use of immobilized templates -a new approach in molecular imprinting.Crossref | GoogleScholarGoogle Scholar |

[55]  N Pérez, MJ Whitcombe, EN Vulfson, Surface imprinting of cholesterol on submicrometer core-shell emulsion particles. Macromolecules 2001, 34, 830.
         | Surface imprinting of cholesterol on submicrometer core-shell emulsion particles.Crossref | GoogleScholarGoogle Scholar |

[56]  H-H Yang, S-Q Zhang, F Tan, et al. Surface molecularly imprinted nanowires for biorecognition. J Am Chem Soc 2005, 127, 1378.
         | Surface molecularly imprinted nanowires for biorecognition.Crossref | GoogleScholarGoogle Scholar |

[57]  Y Li, H-H Yang, Q-H You, et al. Protein recognition via surface molecularly imprinted polymer nanowires. Anal Chem 2006, 78, 317.
         | Protein recognition via surface molecularly imprinted polymer nanowires.Crossref | GoogleScholarGoogle Scholar |

[58]  TL Panasyuk, VM Mirsky, SA Piletsky, OS Wolfbeis, Electropolymerized molecularly imprinted polymers as receptor layers in capacitive chemical sensor. Anal Chem 1999, 71, 4609.
         | Electropolymerized molecularly imprinted polymers as receptor layers in capacitive chemical sensor.Crossref | GoogleScholarGoogle Scholar |

[59]  A Ramanaviciene, A Ramanavicius, Molecularly imprinted polypyrrole-based synthetic receptor for direct detection of bovine leukemia virus glycoproteins. Biosens Bioelectron 2004, 20, 1076.
         | Molecularly imprinted polypyrrole-based synthetic receptor for direct detection of bovine leukemia virus glycoproteins.Crossref | GoogleScholarGoogle Scholar |

[60]  J Li, F Jiang, X Wei, Molecularly imprinted sensor based on an enzyme amplifier for ultratrace oxytetracycline determination. Anal Chem 2010, 82, 6074.
         | Molecularly imprinted sensor based on an enzyme amplifier for ultratrace oxytetracycline determination.Crossref | GoogleScholarGoogle Scholar |

[61]  D Yu, W Jjiang, Y Zhang, Progress in Modification of Surface Grafting Polymerization on Silica Nanoparticle. Paint Coat Ind 2010, 40, 62.

[62]  S Bhakta, MSI Seraji, SL Suib, et al. Antibody-like Biorecognition Sites for Proteins from Surface Imprinting on Nanoparticles. ACS Appl Mater Interfaces 2015, 7, 28197.
         | Antibody-like Biorecognition Sites for Proteins from Surface Imprinting on Nanoparticles.Crossref | GoogleScholarGoogle Scholar |

[63]  Z Xia, Z Lin, X Yun, et al. Facile synthesis of polydopamine-coated molecularly imprinted silica nano particles for protein recognition and separation. Biosens Bioelectron 2013, 47, 120.
         | Facile synthesis of polydopamine-coated molecularly imprinted silica nano particles for protein recognition and separation.Crossref | GoogleScholarGoogle Scholar |

[64]  A Nematollahzadeh, A Shojaei, MJ Abdekhodaie, et al. Molecularly imprinted polydopamine nano-layer on the pore surface of porous particles for protein capture in HPLC column. J Colloid Interface Sci 2013, 404, 117.
         | Molecularly imprinted polydopamine nano-layer on the pore surface of porous particles for protein capture in HPLC column.Crossref | GoogleScholarGoogle Scholar |

[65]  C Boitard, A Lamouri, C Ménager, et al. Whole Protein Imprinting over Magnetic Nanoparticles Using Photopolymerization. ACS Appl Polym Mater 2019, 1, 928.
         | Whole Protein Imprinting over Magnetic Nanoparticles Using Photopolymerization.Crossref | GoogleScholarGoogle Scholar |

[66]  J Qi, B Li, X Wang, et al. Rotational Paper-Based Microfluidic-Chip Device for Multiplexed and Simultaneous Fluorescence Detection of Phenolic Pollutants Based on a Molecular-Imprinting Technique. Anal Chem 2018, 90, 11827.
         | Rotational Paper-Based Microfluidic-Chip Device for Multiplexed and Simultaneous Fluorescence Detection of Phenolic Pollutants Based on a Molecular-Imprinting Technique.Crossref | GoogleScholarGoogle Scholar |

[67]  F Chen, M Mao, J Wang, A dual-step immobilization/imprinting approach to prepare magnetic molecular imprinted polymers for selective removal of human serum albumin. Talanta 2020, 209, 120509.
         | A dual-step immobilization/imprinting approach to prepare magnetic molecular imprinted polymers for selective removal of human serum albumin.Crossref | GoogleScholarGoogle Scholar |

[68]  A Tretjakov, V Syritski, J Reut, et al. Surface molecularly imprinted polydopamine films for recognition of immunoglobulin G. Microchim Acta 2013, 180, 1433.
         | Surface molecularly imprinted polydopamine films for recognition of immunoglobulin G.Crossref | GoogleScholarGoogle Scholar |

[69]  R Ma, X Sun, W Ha, et al. Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG. J Mater Chem B 2017, 5, 7512.
         | Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG.Crossref | GoogleScholarGoogle Scholar |

[70]  Z Liu, Z-Z Yin, W Cai, D Wu, J Li, Y Kong, A surface protein-imprinted biosensor based on boronate affinity for the detection of anti-human immunoglobulin G. Microchim Acta 2022, 189, 106.
         | A surface protein-imprinted biosensor based on boronate affinity for the detection of anti-human immunoglobulin G.Crossref | GoogleScholarGoogle Scholar |

[71]  Y Zhang, H Cao, Q Huang, et al. Isolation of transferrin by imprinted nanoparticles with magnetic deep eutectic solvents as monomer. Anal Bioanal Chem 2018, 410, 6237.
         | Isolation of transferrin by imprinted nanoparticles with magnetic deep eutectic solvents as monomer.Crossref | GoogleScholarGoogle Scholar |

[72]  A Rachkov, N Minoura, Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach. Biochim Biophys Acta Protein Struct Mol Enzymol 2001, 1544, 255.
         | Towards molecularly imprinted polymers selective to peptides and proteins. The epitope approach.Crossref | GoogleScholarGoogle Scholar |

[73]  A Rachkov, N Minoura, Recognition of oxytocin and oxytocin-related peptides in aqueous media using a molecularly imprinted polymer synthesized by the epitope approach. J Chromatogr A 2000, 889, 111.
         | Recognition of oxytocin and oxytocin-related peptides in aqueous media using a molecularly imprinted polymer synthesized by the epitope approach.Crossref | GoogleScholarGoogle Scholar |

[74]  Kaiguang Yang, Jianxi Liu, Senwu Li, et al. Epitope imprinted polyethersulfone beads by self-assembly for target protein capture from the plasma proteome. Chem. Commun 2014, 50, 9521.
         | Epitope imprinted polyethersulfone beads by self-assembly for target protein capture from the plasma proteome.Crossref | GoogleScholarGoogle Scholar |

[75]  GQ Pan, S Shinde, SY Yeung, et al. An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell–Biomaterial Interactions. Angew Chem Int Ed 2017, 56, 15959.
         | An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell–Biomaterial Interactions.Crossref | GoogleScholarGoogle Scholar |

[76]  H Nishino, CS Huang, KJ Shea, Selective protein capture by epitope imprinting. Angew Chem Int Ed 2006, 45, 2392.
         | Selective protein capture by epitope imprinting.Crossref | GoogleScholarGoogle Scholar |

[77]  C Rossetti, MA Świtnicka-Plak, T Grønhaug Halvorsen, PAG Cormack, B Sellergren, L Reubsaet, Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers. Sci Rep 2017, 7, 44298.
         | Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers.Crossref | GoogleScholarGoogle Scholar |

[78]  Y-P Qin, C Jia, X-W He, et al. Thermosensitive Metal Chelation Dual-Template Epitope Imprinting Polymer Using Distillation–Precipitation Polymerization for Simultaneous Recognition of Human Serum Albumin and Transferrin. ACS Appl Mater Interfaces 2018, 10, 9060.
         | Thermosensitive Metal Chelation Dual-Template Epitope Imprinting Polymer Using Distillation–Precipitation Polymerization for Simultaneous Recognition of Human Serum Albumin and Transferrin.Crossref | GoogleScholarGoogle Scholar |

[79]  S Schwark, W Sun, J Stute, et al. Monoclonal antibody capture from cell culture supernatants using epitope imprinted microporous membranes. RSC Adv 2016, 6, 53162.
         | Monoclonal antibody capture from cell culture supernatants using epitope imprinted microporous membranes.Crossref | GoogleScholarGoogle Scholar |

[80]  D Proske, M Blank, R Buhmann, et al. Aptamers-basic Research, Drug Development, and Clinical Applications. Appl Microbiol Biotechnol 2005, 69, 367.
         | Aptamers-basic Research, Drug Development, and Clinical Applications.Crossref | GoogleScholarGoogle Scholar |

[81]  M Mascini, I Palchetti, S Tombelli, Nucleic Acid and Peptide Aptamers: Fundamentals and Bioanalytical Aspects. Angew Chem Int Ed 2012, 51, 1316.
         | Nucleic Acid and Peptide Aptamers: Fundamentals and Bioanalytical Aspects.Crossref | GoogleScholarGoogle Scholar |

[82]  T Wang, C Chen, LM Larcher, et al. Three Decades of Nucleic Acid Aptamer Technologies: Lessons Learned, Progress and Opportunities on Aptamer Development. Biotechnol Adv 2019, 37, 28.
         | Three Decades of Nucleic Acid Aptamer Technologies: Lessons Learned, Progress and Opportunities on Aptamer Development.Crossref | GoogleScholarGoogle Scholar |

[83]  P Jolly, V Tamboli, RL Harniman, et al. Aptamer-MIP Hybrid Receptor for Highly Sensitive Electrochemical Detection of Prostate Specific Antigen. Biosens Bioelectron 2016, 75, 188.
         | Aptamer-MIP Hybrid Receptor for Highly Sensitive Electrochemical Detection of Prostate Specific Antigen.Crossref | GoogleScholarGoogle Scholar |

[84]  Z Zhang, J Liu, Molecularly Imprinted Polymers with DNA Aptamer Fragments as Macromonomers. ACS Appl Mater Interfaces 2016, 8, 6371.
         | Molecularly Imprinted Polymers with DNA Aptamer Fragments as Macromonomers.Crossref | GoogleScholarGoogle Scholar |

[85]  Y-J Liao, Y-C Shiang, C-C Huang, et al. Molecularly imprinted aptamers of gold nanoparticles for the enzymatic inhibition and detection of thrombin. Langmuir 2012, 28, 8944.
         | Molecularly imprinted aptamers of gold nanoparticles for the enzymatic inhibition and detection of thrombin.Crossref | GoogleScholarGoogle Scholar |

[86]  J Zhai, M Zhao, X Cao, et al. Metal-Ion-Responsive Bionanocomposite for Selective and Reversible Enzyme Inhibition. J Am Chem Soc 2018, 140, 16925.
         | Metal-Ion-Responsive Bionanocomposite for Selective and Reversible Enzyme Inhibition.Crossref | GoogleScholarGoogle Scholar |

[87]  Y Kamon, T Takeuchi, Molecularly Imprinted Nanocavities Capable of Ligand-Binding Domain and Size/Shape Recognition for Selective Discrimination of Vascular Endothelial Growth Factor Isoforms. ACS Sens 2018, 3, 580.
         | Molecularly Imprinted Nanocavities Capable of Ligand-Binding Domain and Size/Shape Recognition for Selective Discrimination of Vascular Endothelial Growth Factor Isoforms.Crossref | GoogleScholarGoogle Scholar |

[88]  KJ Jetzschmann, S Tank, G Jágerszki, et al. Bio-Electrosynthesis of Vectorially Imprinted Polymer Nanofilms for Cytochrome P450cam. ChemElectroChem 2019, 6, 1818.
         | Bio-Electrosynthesis of Vectorially Imprinted Polymer Nanofilms for Cytochrome P450cam.Crossref | GoogleScholarGoogle Scholar |

[89]  J Bognár, J Szűcs, Z Dorkó, et al. Nanosphere Lithography as a Versatile Method to Generate Surface-Imprinted Polymer Films for Selective Protein Recognition. Adv Funct Mater 2013, 23, 4703.
         | Nanosphere Lithography as a Versatile Method to Generate Surface-Imprinted Polymer Films for Selective Protein Recognition.Crossref | GoogleScholarGoogle Scholar |

[90]  HQ Zhang, JS Jiang, HT Zhang, et al. Efficient Synthesis of Molecularly Imprinted Polymers with Enzyme Inhibition Potency by the Controlled Surface Imprinting Approach. ACS Macro Lett 2013, 2, 566.
         | Efficient Synthesis of Molecularly Imprinted Polymers with Enzyme Inhibition Potency by the Controlled Surface Imprinting Approach.Crossref | GoogleScholarGoogle Scholar |

[91]  A Guerreiro, A Poma, K Karim, et al. Influence of Surface-Imprinted Nanoparticles on Trypsin Activity. Adv Healthc Mater 2014, 3, 1426.
         | Influence of Surface-Imprinted Nanoparticles on Trypsin Activity.Crossref | GoogleScholarGoogle Scholar |

[92]  Y Kamon, R Matsuura, Y Kitayama, et al. Precisely Controlled Molecular Imprinting of Glutathione-s-Trans-ferase by Orientated Template Immobilization using Specific Interaction with an Anchored Ligand on a Gold Substrate. Polym Chem 2014, 5, 4764.
         | Precisely Controlled Molecular Imprinting of Glutathione-s-Trans-ferase by Orientated Template Immobilization using Specific Interaction with an Anchored Ligand on a Gold Substrate.Crossref | GoogleScholarGoogle Scholar |

[93]  KJ Jetzschmann, G Jágerszki, D Dechtrirat, et al. Vectorially Imprinted Hybrid Nanofilm for Acetylcholinesterase Recognition. Adv Funct Mater 2015, 25, 5178.
         | Vectorially Imprinted Hybrid Nanofilm for Acetylcholinesterase Recognition.Crossref | GoogleScholarGoogle Scholar |

[94]  L Peng, A Yarman, KJ Jetzschmann, et al. Molecularly Imprinted Electropolymer for a Hexameric Heme Protein with Direct Electron Transfer and Peroxide Electrocatalysis. Sensors 2016, 16, 272.
         | Molecularly Imprinted Electropolymer for a Hexameric Heme Protein with Direct Electron Transfer and Peroxide Electrocatalysis.Crossref | GoogleScholarGoogle Scholar |

[95]  D Dechtrirat, KJ Jetzschmann, WFM Stoecklein, et al. Protein Rebinding to a Surface-Confined Imprint. Adv Funct Mater 2012, 22, 5231.
         | Protein Rebinding to a Surface-Confined Imprint.Crossref | GoogleScholarGoogle Scholar |

[96]  H Chen, J Kong, D Yuan, et al. Synthesis of surface molecularly imprinted nanoparticles for recognition of lysozyme using a metal coordination monomer. Biosens Bioelectron 2014, 53, 5.
         | Synthesis of surface molecularly imprinted nanoparticles for recognition of lysozyme using a metal coordination monomer.Crossref | GoogleScholarGoogle Scholar |

[97]  L Qin, XW He, W Zhang, et al. Macroporous thermosensitive imprinted hydrogel for recognition of protein by metal coordinate interaction. Anal Chem 2009, 81, 7206.
         | Macroporous thermosensitive imprinted hydrogel for recognition of protein by metal coordinate interaction.Crossref | GoogleScholarGoogle Scholar |

[98]  Block H, Maertens B, Spriestersbach A, et al. Immobilized-metal affinity chromatography (IMAC): A review. In: Burgess RR, Deutscher MP, editors. Guide to Protein Purification, 2nd edn. Vol. 463 . Methods in Enzymology. Academic Press; 2009. pp. 439–473.

[99]  S Li, K Yang, J Liu, B Jiang, L Zhang, Y Zhang, Surface-Imprinted Nanoparticles Prepared with a His-Tag-Anchored Epitope as the Template. Anal Chem 2015, 87, 4617.
         | Surface-Imprinted Nanoparticles Prepared with a His-Tag-Anchored Epitope as the Template.Crossref | GoogleScholarGoogle Scholar |

[100]  S Li, K Yang, B Zhao, et al. Epitope Imprinting Enhanced IMAC (EI-IMAC) for Highly Selective Purification of His-tagged Protein. J Mater Chem B 2016, 4, 1960.
         | Epitope Imprinting Enhanced IMAC (EI-IMAC) for Highly Selective Purification of His-tagged Protein.Crossref | GoogleScholarGoogle Scholar |

[101]  X Zhang, X Du, Creation of Glycoprotein Imprinted Self-Assembled Monolayers with Dynamic Boronate Recognition Sites and Imprinted Cavities for Selective Glycoprotein Recognition. Soft Matter 2020, 16, 3039.
         | Creation of Glycoprotein Imprinted Self-Assembled Monolayers with Dynamic Boronate Recognition Sites and Imprinted Cavities for Selective Glycoprotein Recognition.Crossref | GoogleScholarGoogle Scholar |

[102]  Z Liu, H He, Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity. Acc Chem Res 2017, 50, 2185.
         | Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity.Crossref | GoogleScholarGoogle Scholar |

[103]  T Morishige, E Takano, H Sunayama, Y Kitayama, T Takeuchi, Post-Imprinting-Modified Molecularly Imprinted Nanocavities with Two Synergetic, Orthogonal, Glycoprotein-Binding Sites to Transduce Binding Events into Fluorescence Changes. ChemNanoMat 2019, 5, 224.
         | Post-Imprinting-Modified Molecularly Imprinted Nanocavities with Two Synergetic, Orthogonal, Glycoprotein-Binding Sites to Transduce Binding Events into Fluorescence Changes.Crossref | GoogleScholarGoogle Scholar |

[104]  X Bi, Z Liu, Enzyme Activity Assay of Glycoprotein Enzymes Based on a Boronate Affinity Molecularly Imprinted 96-Well Microplate. Anal Chem 2014, 86, 12382.
         | Enzyme Activity Assay of Glycoprotein Enzymes Based on a Boronate Affinity Molecularly Imprinted 96-Well Microplate.Crossref | GoogleScholarGoogle Scholar |

[105]  S Wang, J Ye, Z Bie, et al. Affinity-Tunable Specific Recognition of Glycoproteins via Boronate Affinity-based Control-lable Oriented Surface Imprinting. Chem Sci 2014, 5, 1135.
         | Affinity-Tunable Specific Recognition of Glycoproteins via Boronate Affinity-based Control-lable Oriented Surface Imprinting.Crossref | GoogleScholarGoogle Scholar |

[106]  R-t Ma, X-y Sun, W Ha, et al. Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG. J Mater Chem B 2017, 5, 7512.
         | Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG.Crossref | GoogleScholarGoogle Scholar |

[107]  T Saeki, H Sunayama, Y Kitayama, et al. Orientationally Fabricated Zwitterionic Molecularly Imprinted Nano-cavities for Highly Sensitive Glycoprotein Recognition. Langmuir 2019, 35, 1320.
         | Orientationally Fabricated Zwitterionic Molecularly Imprinted Nano-cavities for Highly Sensitive Glycoprotein Recognition.Crossref | GoogleScholarGoogle Scholar |

[108]  R Xing, Y Ma, Y Wang, et al. Specific Recognition of Proteins and Peptides via Controllable Oriented Surface Imprinting of Boronate Affinity-Anchored Epitopes. Chem Sci 2019, 10, 1831.
         | Specific Recognition of Proteins and Peptides via Controllable Oriented Surface Imprinting of Boronate Affinity-Anchored Epitopes.Crossref | GoogleScholarGoogle Scholar |

[109]  Q Li, K Yang, L Senwu, et al. Preparation of epitope imprinted particles for transferrin recognition by reversible addition fragmentation chain transfer strategy. Chin J Chromatogr 2014, 32, 1029.
         | Preparation of epitope imprinted particles for transferrin recognition by reversible addition fragmentation chain transfer strategy.Crossref | GoogleScholarGoogle Scholar |

[110]  LN Gómez-Arribas, D María del Mar, G Nuria, et al. Hierarchically Imprinted Polymer for Peptide Tag Recognition Based on an Oriented Surface Epitope Approach. ACS Appl Mater Interfaces 2020, 12, 49111.
         | Hierarchically Imprinted Polymer for Peptide Tag Recognition Based on an Oriented Surface Epitope Approach.Crossref | GoogleScholarGoogle Scholar |

[111]  VV Ugrozov, Reversible kinetics of physical adsorption on homogeneous surface. Colloid J 2009, 71, 559.
         | Reversible kinetics of physical adsorption on homogeneous surface.Crossref | GoogleScholarGoogle Scholar |

[112]  L Tan, Z Yu, X Zhou, et al. Antibody-free ultra-high performance liquid chromatography/tandem mass spectrometry measurement of angiotensin I and II using magnetic epitope-imprinted polymers. J Chromatogr A 2015, 1411, 69.
         | Antibody-free ultra-high performance liquid chromatography/tandem mass spectrometry measurement of angiotensin I and II using magnetic epitope-imprinted polymers.Crossref | GoogleScholarGoogle Scholar |

[113]  X Zhang, N Zhang, C Du, et al. Preparation of magnetic epitope imprinted polymer microspheres using cyclodextrin-based ionic liquids as functional monomer for highly selective and effective enrichment of cytochrome c. Chem Eng J 2017, 317, 988.
         | Preparation of magnetic epitope imprinted polymer microspheres using cyclodextrin-based ionic liquids as functional monomer for highly selective and effective enrichment of cytochrome c.Crossref | GoogleScholarGoogle Scholar |

[114]  G Wu, J Li, X Qu, et al. Template Size Matched Film Thickness for Effectively in situ Surface Imprinting: a Model Study of Glycoprotein Imprints. RSC Adv 2015, 5, 47010.
         | Template Size Matched Film Thickness for Effectively in situ Surface Imprinting: a Model Study of Glycoprotein Imprints.Crossref | GoogleScholarGoogle Scholar |

[115]  R Xing, Y Ma, Y Wang, et al. Specific Recognition of Proteins and Peptides via Controllable Oriented Surface Imprinting of Boronate Affinity-Anchored Epitopes. Chem Sci 2019, 10, 1831.
         | Specific Recognition of Proteins and Peptides via Controllable Oriented Surface Imprinting of Boronate Affinity-Anchored Epitopes.Crossref | GoogleScholarGoogle Scholar |

[116]  X Wei, X Li, SM Husson, Surface Molecular Imprinting by Atom Transfer Radical Polymerization. Biomacromolecules 2005, 6, 1113.
         | Surface Molecular Imprinting by Atom Transfer Radical Polymerization.Crossref | GoogleScholarGoogle Scholar |

[117]  AJ Ryan, J Ghuman, A Zunszain, et al. Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin. J Struct Biol 2011, 174, 84.
         | Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.Crossref | GoogleScholarGoogle Scholar |

[118]  R Xing, Z Guo, H Lu, et al. Molecular imprinting and cladding produces antibody mimics with significantly improved affinity and specificity. Sci Bull 2022, 67, 278.
         | Molecular imprinting and cladding produces antibody mimics with significantly improved affinity and specificity.Crossref | GoogleScholarGoogle Scholar |