Two Metal–Organic Coordination Polymers Based on Polypyridyl Ligands: Crystal Structures and Inhibition of Human Spinal Tumour Cells
Hua-Jie Mao A , Qi-Xin Chen A B and Bin Han AA Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China.
B Corresponding author. Email: zrcqx@zju.edu.cn
Australian Journal of Chemistry 71(11) 902-906 https://doi.org/10.1071/CH18274
Submitted: 4 June 2018 Accepted: 11 September 2018 Published: 11 October 2018
Abstract
In this work, two new metal–organic coordination polymers [Co2.5(dtp)2(H2O)5](NO3)(H2O)2 (1, H2dtp = 4′-(3,5-dicarboxyphenyl)-2,2′:6′,2″-terpyridine) [Ni(dpt)](H2O)3 (2, H2dpt = 4′-(3,5-dicarboxyphenyl)-4,2′:6′,4″- terpyridine) have been successfully prepared by reaction of metal ions with two similar carboxylic-pyridinyl ligands with different arrangement of N atoms of terpyridines under solvothermal conditions. Powder X-ray diffraction, elemental analysis, and single-crystal X-ray diffraction techniques were used to probe the structures of the as-prepared complexes. The CoII-based complex 1 exhibits a finite molecular structure and 2 displays a 3D porous framework with a 1D channel. Furthermore, the in vitro anticancer activity of complexes 1 and 2 was evaluated via the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay against U-266, MM1S, and RPMI-8226 human spinal tumour cells.
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