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RESEARCH ARTICLE (Open Access)

2023 Undetectable = Untransmittable global policy roundtable report: a multistakeholder perspective on Undetectable = Untransmittable research and policy priorities

N. Wells https://orcid.org/0000-0002-2827-8480 A * , B. Richman B , D. Grace https://orcid.org/0000-0002-9032-3959 C , B. Riley D , C. Hui https://orcid.org/0000-0002-6569-7422 E F , L. Vojnov G , L. Stackpool-Moore H , J. J. Ong https://orcid.org/0000-0001-5784-7403 I J , A. Dowell-Day D and B. Allan K
+ Author Affiliations
- Author Affiliations

A Kirby Institute, University of NSW, Sydney, NSW, Australia.

B Prevention Access Campaign, New York, NY, USA.

C Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

D ASHM Health, Sydney, NSW, Australia.

E School of Public Policy and Democratic Innovations, Toronto Metropolitan University, Toronto, ON, Canada.

F Ontario Positive Asians, Toronto, ON, Canada.

G World Health Organization, Geneva, Switzerland.

H Watipa, Sydney, NSW, Australia.

I Central Clinical School, Monash University, Melbourne, Vic., Australia.

J Melbourne Sexual Health Centre, Alfred Health, Melbourne, Vic., Australia.

K Qthink Consulting, Malmsbury, Vic., Australia.

* Correspondence to: nwells@kirby.unsw.edu.au

Handling Editor: Jami Leichliter

Sexual Health 21, SH24017 https://doi.org/10.1071/SH24017
Submitted: 24 January 2024  Accepted: 1 May 2024  Published: 27 May 2024

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)

Abstract

Background

Launched in 2016 by Prevention Access Campaign, the ‘Undetectable = Untransmittable’ (U=U) campaign empowers people living with HIV to live full social, sexual and reproductive lives, dismantle stigma, promote increased treatment access, and advocate for updated HIV guidelines.

Methods

Key priorities for promoting improvements to community-centred, evidence-informed U=U policy and research were the focus of a half-day global roundtable held in 2023 alongside the 12th International AIDS Society Conference in Brisbane, Australia. After a series of presentations, experts in U=U research, policymaking, advocacy and HIV clinical care participated in facilitated discussions, and detailed notes were taken on issues related to advancing U=U policy and research.

Results

Expert participants shared that knowledge and trust in U=U remains uneven, and is largely concentrated among people living with HIV, particularly those connected to gay and bisexual networks. It was agreed that there is a need to ensure all members of priority populations are explicitly included in U=U policies that promote U=U. Participants also identified a need for policymakers, healthcare professionals, advocates and researchers to work closely with community-based organisations to ensure the U=U message is relevant, useful, and utilised in the HIV response. Adopting language, such as ‘zero risk’, was identified as crucial when describing undetectable viral load as an effective HIV prevention strategy.

Conclusion

U=U can have significant benefits for the mental and physical wellbeing of people living with HIV. There is an urgent need to address the structural barriers to HIV care and treatment access to ensure the full benefits of U=U are realised.

Keywords: health equity, HIV, HIV prevention, HIV treatment, Prevention Access Campaign, stigma, U=U, undetectable viral load.

References

Rendina HJ, Talan AJ, Cienfuegos-Szalay J, Carter JA, Shalhav O. Treatment is more than prevention: perceived personal and social benefits of Undetectable = Untransmittable messaging among sexual minority men living with HIV. AIDS Patient Care STDs 2020; 34(10): 444-51.
| Crossref | Google Scholar | PubMed |

Bavinton BR, Pinto AN, Phanuphak N, Grinsztejn B, Prestage GP, Zablotska-Manos IB, et al. Viral suppression and HIV transmission in serodiscordant male couples: an international, prospective, observational, cohort study. Lancet HIV 2018; 5(8): e438-47.
| Crossref | Google Scholar | PubMed |

Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, van Lunzen J, et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. J Am Med Assoc 2016; 316(2): 171-81.
| Crossref | Google Scholar |

Prevention Access Campaign. Prevention Access Campaign | The revolution in living and loving with HIV; 2023. Available at https://preventionaccess.com/ [cited 16 November 2023]

Ford OG, Rufurwadzo TG, Richman B, Green I, Alesi J. Adopting U = U to end stigma and discrimination. J Int AIDS Soc 2022; 25(3): e25891.
| Crossref | Google Scholar | PubMed |

Okoli C, Van de Velde N, Richman B, Allan B, Castellanos E, Young B, et al. Undetectable equals untransmittable (U = U): awareness and associations with health outcomes among people living with HIV in 25 countries. Sex Transm Infect 2021; 97(1): 18-26.
| Crossref | Google Scholar | PubMed |

Grace D, Chown SA, Kwag M, Steinberg M, Lim E, Gilbert M. Becoming “Undetectable”: longitudinal narratives of gay men’s sex lives after a recent HIV diagnosis. AIDS Educ Prev 2015; 27(4): 333-49.
| Crossref | Google Scholar | PubMed |

Wells N, Philpot S, Murphy D, Ellard J, Howard C, Prestage G. ‘It’s like I have this weird superpower’: experiences of detectable and undetectable viral load among a cohort of recently diagnosed people living with HIV. Sex Health 2023; 20(3): 195-201.
| Crossref | Google Scholar | PubMed |

Hui C. Undetectable=Untransmittable=Universal Access (U=U=U): transforming a foundational, community-led HIV/AIDS health informational advocacy campaign into a global HIV/AIDS health equity strategy and policy priority. Sex Health 2023; 20(3): 186-94.
| Crossref | Google Scholar |

10  Frescura L, Godfrey-Faussett P, Feizzadeh A. A, El-Sadr W, Syarif O, Ghys PD. Achieving the 95 95 95 targets for all: a pathway to ending AIDS. PLoS ONE 2022; 17(8): e0272405.
| Crossref | Google Scholar | PubMed |

11  Braun V, Clarke V, Hayfield N, Terry G. Thematic analysis. In: Liamputtong P, editor. Handbook of research methods in health social sciences. Singapore: Springer; 2019. pp. 843–60.

12  Bor J, Fischer C, Modi M, Richman B, Kinker C, King R, et al. changing knowledge and attitudes towards HIV treatment-as-prevention and “Undetectable = Untransmittable”: a systematic review. AIDS Behav 2021; 25(12): 4209-24.
| Crossref | Google Scholar | PubMed |

13  Card KG, Armstrong HL, Lachowsky NJ, Cui Z, Sereda P, Carter A, et al. Belief in treatment as prevention and its relationship to HIV status and behavioral risk. J Acquir Immune Defic Syndr 2018; 77(1): 8-16.
| Crossref | Google Scholar |

14  Coyne R, Walsh JC, Noone C. Awareness, understanding and HIV stigma in response to Undetectable = Untransmittable messages: findings from a nationally representative sample in the United Kingdom. AIDS Behav 2022; 26: 3818-26.
| Crossref | Google Scholar |

15  Grace D, Daroya E, Gaspar M, Wells A, Hull M, Lachowsky N, et al. Gay, bisexual, and queer men’s confidence in the Undetectable equals Untransmittable HIV prevention message: longitudinal qualitative analysis of the sexual decision-making of pre-exposure prophylaxis users over time. Sex Health 2023; 20(3): 223-31.
| Crossref | Google Scholar |

16  Holt M, Draper BL, Pedrana AE, Wilkinson AL, Stoové M. Comfort relying on HIV pre-exposure prophylaxis and treatment as prevention for condomless sex: results of an online survey of Australian gay and bisexual men. AIDS Behav 2018; 22(11): 3617-26.
| Crossref | Google Scholar | PubMed |

17  MacGibbon J, Bavinton BR, Broady TR, Ellard J, Murphy D, Calabrese SK, et al. Familiarity with, perceived accuracy of, and willingness to rely on Undetectable=Untransmittable (U=U) among gay and bisexual men in Australia: results of a national cross-sectional survey. Sex Health 2023; 20(3): 211-22.
| Crossref | Google Scholar |

18  Ngure K, Ongolly F, Dolla A, Awour M, Mugwanya KK, Irungu E, et al. “I just believe there is a risk” understanding of undetectable equals untransmissible (U = U) among health providers and HIV-negative partners in serodiscordant relationships in Kenya. J Int AIDS Soc 2020; 23(3): e25466.
| Crossref | Google Scholar | PubMed |

19  Siegel K, Meunier É. Awareness and perceived effectiveness of HIV treatment as prevention among men who have sex with men in New York City. AIDS Behav 2019; 23(7): 1974-83.
| Crossref | Google Scholar | PubMed |

20  Agarwal H, Yeatts K, Chung SR, Harrison-Quintana J, Torres TS. Perceived accuracy around Undetectable = Untransmitable among sexual and gender minorities using smartphones in India. AIDS Behav 2024; 28: 1039-46.
| Crossref | Google Scholar |

21  Torres TS, Cox J, Marins LM, Bezerra DR, Veloso VG, Grinsztejn B, et al. A call to improve understanding of Undetectable equals Untransmittable (U = U) in Brazil: a web-based survey. J Int AIDS Soc 2020; 23(11): e25630.
| Crossref | Google Scholar | PubMed |

22  Rivera AV, Carrillo SA, Braunstein SL. Prevalence of U = U awareness and its association with anticipated HIV stigma among low-income heterosexually active black and latino adults in New York City, 2019. AIDS Patient Care STDs 2021; 35(9): 370-6.
| Crossref | Google Scholar | PubMed |

23  Grace D, Stewart M, Blaque E, Ryu H, Anand P, Gaspar M, et al. Challenges to communicating the Undetectable equals Untransmittable (U=U) HIV prevention message: healthcare provider perspectives. PLoS ONE 2022; 17(7): e0271607.
| Crossref | Google Scholar | PubMed |

24  Wu J, Fairley CK, Grace D, Chow EPF, Ong JJ. Agreement of and discussion with clients about Undetectable equals Untransmissible among general practitioners in Australia: a cross-sectional survey. Sex Health 2023; 20: 242-9.
| Crossref | Google Scholar |

25  Calabrese SK, Mayer KH. Stigma impedes HIV prevention by stifling patient–provider communication about U = U. J Int AIDS Soc 2020; 23(7): e25559.
| Crossref | Google Scholar | PubMed |

26  World Health Organization. The role of HIV viral suppression in improving individual health and reducing transmission: policy brief. Geneva: World Health Organization; 2023.

27  World Health Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: World Health Organization; 2021. Available at https://www.who.int/publications-detail-redirect/9789240031593 [cited 7 December 2023]

28  Paschen-Wolff MM, Campbell ANC, Tross S, Castro M, Berg H, Braunstein S, et al. HIV treatment knowledge in the context of “Treatment as Prevention” (TasP). AIDS Behav 2020; 24(10): 2984-94.
| Crossref | Google Scholar | PubMed |

29  Ahmed S, Autrey J, Katz IT, Fox MP, Rosen S, Onoya D, et al. Why do people living with HIV not initiate treatment? A systematic review of qualitative evidence from low- and middle-income countries. Soc Sci Med 2018; 213: 72-84.
| Crossref | Google Scholar | PubMed |

30  Guta A, Murray SJ, Gagnon M. HIV, viral suppression and new technologies of surveillance and control. Body Soc 2016; 22(2): 82-107.
| Crossref | Google Scholar |

31  Tan RKJ, Lim JM, Chan JKW. Is “Undetectable = Untransmissible” Good Public Health Messaging? AMA J Ethics 2021; 23(5): E418-22.
| Google Scholar | PubMed |

32  Pantelic M, Steinert JI, Park J, Mellors S, Murau F. ‘Management of a spoiled identity’: systematic review of interventions to address self-stigma among people living with and affected by HIV. BMJ Glob Health 2019; 4(2): e001285.
| Crossref | Google Scholar | PubMed |

33  Sangaramoorthy T, Jamison AM, Dyer TV. HIV stigma, retention in care, and adherence among older black women living with HIV. J Assoc Nurses AIDS Care 2017; 28(4): 518-31.
| Crossref | Google Scholar |

34  Wells N, Murphy D, Ellard J, Philpot SP, Prestage G. HIV diagnosis as both biographical disruption and biographical reinforcement: experiences of HIV diagnoses among recently diagnosed people living with HIV. Qual Health Res 2023; 33(3): 165-75.
| Crossref | Google Scholar | PubMed |

35  Prevention Access Campaign. Win-Win agenda; 2023. Available at https://preventionaccess.org/winwin/ [cited 13 December 2023]