Sexually transmitted infection testing and prevalence among MSM using event-based dosing HIV pre-exposure prophylaxis
Kiersten Simmons A , Colin Fitzpatrick A and Daniel Richardson
A B *
+ Author Affiliations
- Author Affiliations
A Department of Sexual Health & HIV Medicine, University Hospitals Sussex NHS Foundation Trust, Brighton BN2 5BE, UK.
B Brighton & Sussex Medical School, Brighton, UK.
Sexual Health 20(2) 177-179 https://doi.org/10.1071/SH22192
Submitted: 3 December 2022 Accepted: 11 January 2023 Published: 30 January 2023
© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing
Abstract
Event-based dosing (EBD) of HIV PrEP is as effective at preventing HIV transmission in MSM as daily dosing. There are limited data on the differences in STI testing frequency between MSM using EBD-PrEP and daily dosing. A total of 20% of 418 PrEP users were using EBD-PrEP and had a lower number of sexual partners (22 (27%) vs 142 (42%), P = 0.008), tested for STIs less frequently (115 (18%) vs 69 (50%), P < 0.001), but were diagnosed with a similar number of STIs ((35% vs 34%, P = 0.54) compared to daily users. More research is needed to understand the optimal frequency for STI testing in MSM using EBD PrEP.
Keywords: Chlamydia trachomatis, HIV prevention, Neisseria gonorrhoeae, pre-exposure prophylaxis, sexual behaviour, sexually transmitted infections, sexually transmitted infection testing, Treponema pallidum.
References
[1] Molina JM, Ghosn J, Assoumou L, Delaugerre C, Algarte-Genin M, Pialoux G, et al. Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study. Lancet HIV 2022; 9 e554–e62.| Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study.Crossref | GoogleScholarGoogle Scholar |
[2] Kwan TH, Lui GCY, Lam TTN, Lee KCK, Wong NS, Chan DPC, et al. Comparison between daily and on-demand PrEP (pre-exposure prophylaxis) regimen in covering condomless anal intercourse for men who have sex with men in Hong Kong: a randomized, controlled, open-label, crossover trial. J Int AIDS Soc 2021; 24 e25795
| Comparison between daily and on-demand PrEP (pre-exposure prophylaxis) regimen in covering condomless anal intercourse for men who have sex with men in Hong Kong: a randomized, controlled, open-label, crossover trial.Crossref | GoogleScholarGoogle Scholar |
[3] Traeger MW, Cornelisse VJ, Asselin J, Price B, Roth NJ, Willcox J, et al. Association of HIV preexposure prophylaxis with incidence of sexually transmitted infections among individuals at high risk of HIV infection. JAMA 2019; 321 1380–90.
| Association of HIV preexposure prophylaxis with incidence of sexually transmitted infections among individuals at high risk of HIV infection.Crossref | GoogleScholarGoogle Scholar |
[4] Hoornenborg E, Achterbergh RC, van der Loeff MFS, Davidovich U, van der Helm JJ, Hogewoning A, et al. Men who have sex with men more often chose daily than event-driven use of pre-exposure prophylaxis: baseline analysis of a demonstration study in Amsterdam. J Int AIDS Soc 2018; 21 e25105
| Men who have sex with men more often chose daily than event-driven use of pre-exposure prophylaxis: baseline analysis of a demonstration study in Amsterdam.Crossref | GoogleScholarGoogle Scholar |
[5] Reyniers T, Nöstlinger C, Laga M, De Baetselier I, Crucitti T, Wouters K, et al. Choosing between daily and event-driven pre-exposure prophylaxis: results of a Belgian PrEP demonstration project. J Acquir Immune Defic Syndr 2018; 79 186–94.
| Choosing between daily and event-driven pre-exposure prophylaxis: results of a Belgian PrEP demonstration project.Crossref | GoogleScholarGoogle Scholar |
[6] Vuylsteke B, Reyniers T, De Baetselier I, Nöstlinger C, Crucitti T, Buyze J, et al. Daily and event-driven pre-exposure prophylaxis for men who have sex with men in Belgium: results of a prospective cohort measuring adherence, sexual behaviour and STI incidence. J Int AIDS Soc 2019; 22 e25407
| Daily and event-driven pre-exposure prophylaxis for men who have sex with men in Belgium: results of a prospective cohort measuring adherence, sexual behaviour and STI incidence.Crossref | GoogleScholarGoogle Scholar |
[7] Zhang J, Xu JJ, Wang HY, Huang XJ, Chen YK, Wang H, et al. Preference for daily versus on-demand pre-exposure prophylaxis for HIV and correlates among men who have sex with men: the China real-world oral PrEP demonstration study. J Int AIDS Soc 2021; 24 e25667
| Preference for daily versus on-demand pre-exposure prophylaxis for HIV and correlates among men who have sex with men: the China real-world oral PrEP demonstration study.Crossref | GoogleScholarGoogle Scholar |
[8] Wu H-J, Wen-Wei Ku S, Chang HH, Li C-W, Ko N-Y, Strong C. Imperfect adherence in real life: a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men – a prospective cohort study in Taiwan. J Int AIDS Soc 2021; 24 e25733
| Imperfect adherence in real life: a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men – a prospective cohort study in Taiwan.Crossref | GoogleScholarGoogle Scholar |
[9] Chan C, Fraser D, Grulich AE, Philpot S, Vaughan M, Wacher M, et al. Increased awareness of event-driven PrEP and knowledge of how to use it: results from a cross-sectional survey of gay and bisexual men in Australia. Sex Health 2022; 19 501–8.
| Increased awareness of event-driven PrEP and knowledge of how to use it: results from a cross-sectional survey of gay and bisexual men in Australia.Crossref | GoogleScholarGoogle Scholar |
[10] Closson EF, Mitty JA, Malone J, Mayer KH, Mimiaga MJ. Exploring strategies for PrEP adherence and dosing preferences in the context of sexualized recreational drug use among MSM: a qualitative study. AIDS Care 2018; 30 191–8.
| Exploring strategies for PrEP adherence and dosing preferences in the context of sexualized recreational drug use among MSM: a qualitative study.Crossref | GoogleScholarGoogle Scholar |
[11] Power M, Lewis DA, Richardson D. On-demand HIV pre-exposure prophylaxis: what are the healthcare workers’ barriers to delivery in a culturally and linguistically diverse population? Sex Transm Infect 2020; 96 549
| On-demand HIV pre-exposure prophylaxis: what are the healthcare workers’ barriers to delivery in a culturally and linguistically diverse population?Crossref | GoogleScholarGoogle Scholar |
[12] Jongen VW, Zimmermann HML, Goedhart M, Bogaards JA, Davidovich U, Coyer L, et al. Can we screen less frequently for STI among PrEP users? Assessing the effect of biannual STI screening on timing of diagnosis and transmission risk in the AMPrEP study. Sex Transm Infect 2022;
| Can we screen less frequently for STI among PrEP users? Assessing the effect of biannual STI screening on timing of diagnosis and transmission risk in the AMPrEP study.Crossref | GoogleScholarGoogle Scholar |
[13] Kenyon C. Dual azithromycin/ceftriaxone therapy for gonorrhea in PrEP cohorts results in levels of macrolide consumption that exceed resistance thresholds by up to 7-fold. J Infect Dis 2021; 224 1623–4.
| Dual azithromycin/ceftriaxone therapy for gonorrhea in PrEP cohorts results in levels of macrolide consumption that exceed resistance thresholds by up to 7-fold.Crossref | GoogleScholarGoogle Scholar |
