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RESEARCH ARTICLE

Vascular stiffness and aging in HIV

William Chan A B and Anthony M. Dart A B C
+ Author Affiliations
- Author Affiliations

A Department of Cardiovascular Medicine, the Alfred Hospital, Melbourne, Vic. 3004, Australia.

B The Baker IDI Heart and Diabetes Institute, Melbourne, Vic. 3004, Australia.

C Corresponding author. Email: a.dart@alfred.org.au

Sexual Health 8(4) 474-484 https://doi.org/10.1071/SH10160
Submitted: 13 December 2010  Accepted: 31 March 2011   Published: 29 July 2011

Abstract

Large artery stiffening is a biological index of vascular aging. Vascular aging and atherosclerosis are two closely linked processes that develop in parallel and in synergy, sharing common aetiological determinants. Vascular stiffening increases left ventricular work and can lead to diminished coronary perfusion, and may therefore contribute to the development of cardiovascular disease. There is emerging evidence that large artery stiffness and vascular aging are accelerated in HIV infection because of the high prevalence of cardiovascular risk factors among HIV-infected patients. Moreover, the biological effects of HIV and the metabolic perturbations associated with antiretroviral therapies appear to accelerate vascular stiffening in HIV-infected patients. Further studies evaluating the effects of general and targeted therapies and various combinations of antiretroviral therapies on measures of large artery stiffness are urgently needed.

Additional keywords: AIDS, antiretroviral, carotid intima–media thickness, large artery stiffness, pulse wave velocity, vascular aging.


References

[1]  Marin B, Thiebaut R, Bucher HC, Rondeau V, Costagliola D, Dorrucci M, et al Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy. AIDS 2009; 23 1743–53.
Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[2]  Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005; 352 48–62.
Cardiovascular risk and body-fat abnormalities in HIV-infected adults.Crossref | GoogleScholarGoogle Scholar |

[3]  Henry K, Melroe H, Huebsch J, Hermundson J, Levine C, Swensen L, et al Severe premature coronary artery disease with protease inhibitors. Lancet 1998; 351 1328
Severe premature coronary artery disease with protease inhibitors.Crossref | GoogleScholarGoogle Scholar |

[4]  The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 2003; 349 1993–2003.
The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction.Crossref | GoogleScholarGoogle Scholar |

[5]  Hansson GK. Atherosclerosis – an immune disease: the Anitschkov Lecture 2007. Atherosclerosis 2009; 202 2–10.
Atherosclerosis – an immune disease: the Anitschkov Lecture 2007.Crossref | GoogleScholarGoogle Scholar |

[6]  The DAD Study Group. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007; 356 1723–35.
The DAD Study Group. Class of antiretroviral drugs and the risk of myocardial infarction.Crossref | GoogleScholarGoogle Scholar |

[7]  Saves M, Chene G, Ducimetiere P, Leport C, Le Moal G, Amouyel P, et al Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population. Clin Infect Dis 2003; 37 292–8.
Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population.Crossref | GoogleScholarGoogle Scholar |

[8]  Chan W, Sviridov D, Dart AM. HIV, atherosclerosis and inflammation: implications for treatment. J HIV Ther 2009; 14 61–8.

[9]  Dart AM, Qi XL. Determinants of arterial stiffness in Chinese migrants to Australia. Atherosclerosis 1995; 117 263–72.
Determinants of arterial stiffness in Chinese migrants to Australia.Crossref | GoogleScholarGoogle Scholar |

[10]  Gatzka CD, Cameron JD, Kingwell BA, Dart AM. Relation between coronary artery disease, aortic stiffness, and left ventricular structure in a population sample. Hypertension 1998; 32 575–8.

[11]  O’Rourke MF. The arterial pulse in health and disease. Am Heart J 1971; 82 687–702.
The arterial pulse in health and disease.Crossref | GoogleScholarGoogle Scholar |

[12]  Kingwell BA, Gatzka CD. Arterial stiffness and prediction of cardiovascular risk. J Hypertens 2002; 20 2337–40.
Arterial stiffness and prediction of cardiovascular risk.Crossref | GoogleScholarGoogle Scholar |

[13]  Kingwell BA, Waddell TK, Medley TL, Cameron JD, Dart AM. Large artery stiffness predicts ischemic threshold in patients with coronary artery disease. J Am Coll Cardiol 2002; 40 773–9.
Large artery stiffness predicts ischemic threshold in patients with coronary artery disease.Crossref | GoogleScholarGoogle Scholar |

[14]  Bots ML, Dijk JM, Oren A, Grobbee DE. Carotid intima–media thickness, arterial stiffness and risk of cardiovascular disease: current evidence. J Hypertens 2002; 20 2317–25.
Carotid intima–media thickness, arterial stiffness and risk of cardiovascular disease: current evidence.Crossref | GoogleScholarGoogle Scholar |

[15]  Simionescu M. Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler Thromb Vasc Biol 2007; 27 266–74.
Implications of early structural-functional changes in the endothelium for vascular disease.Crossref | GoogleScholarGoogle Scholar |

[16]  Safar ME, Levy BI, Struijker-Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 2003; 107 2864–9.
Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases.Crossref | GoogleScholarGoogle Scholar |

[17]  Johnson CP, Baugh R, Wilson CA, Burns J. Age related changes in the tunica media of the vertebral artery: implications for the assessment of vessels injured by trauma. J Clin Pathol 2001; 54 139–45.
Age related changes in the tunica media of the vertebral artery: implications for the assessment of vessels injured by trauma.Crossref | GoogleScholarGoogle Scholar |

[18]  Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005; 25 932–43.
Mechanisms, pathophysiology, and therapy of arterial stiffness.Crossref | GoogleScholarGoogle Scholar |

[19]  Benetos A, Laurent S, Hoeks AP, Boutouyrie PH, Safar ME. Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries. Arterioscler Thromb 1993; 13 90–7.

[20]  Dart AM, Kingwell BA. Pulse pressure – a review of mechanisms and clinical relevance. J Am Coll Cardiol 2001; 37 975–84.
Pulse pressure – a review of mechanisms and clinical relevance.Crossref | GoogleScholarGoogle Scholar |

[21]  Smulyan H, Asmar RG, Rudnicki A, London GM, Safar ME. Comparative effects of aging in men and women on the properties of the arterial tree. J Am Coll Cardiol 2001; 37 1374–80.
Comparative effects of aging in men and women on the properties of the arterial tree.Crossref | GoogleScholarGoogle Scholar |

[22]  Gates PE, Tanaka H, Hiatt WR, Seals DR. Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension 2004; 44 35–41.
Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension.Crossref | GoogleScholarGoogle Scholar |

[23]  Bagrov AY, Lakatta EG. The dietary sodium-blood pressure plot “stiffens”. Hypertension 2004; 44 22–4.
The dietary sodium-blood pressure plot “stiffens”.Crossref | GoogleScholarGoogle Scholar |

[24]  Liang YL, Shiel LM, Teede H, Kotsopoulos D, McNeil J, Cameron JD, et al Effects of blood pressure, smoking, and their interaction on carotid artery structure and function. Hypertension 2001; 37 6–11.

[25]  Xu C, Zarins CK, Pannaraj PS, Bassiouny HS, Glagov S. Hypercholesterolemia superimposed by experimental hypertension induces differential distribution of collagen and elastin. Arterioscler Thromb Vasc Biol 2000; 20 2566–72.

[26]  Safar ME, Laurent S, Pannier BM, London GM. Structural and functional modifications of peripheral large arteries in hypertensive patients. J Clin Hypertens 1987; 3 360–7.

[27]  Winlove CP, Parker KH, Avery NC, Bailey AJ. Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties. Diabetologia 1996; 39 1131–9.
Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties.Crossref | GoogleScholarGoogle Scholar |

[28]  Rizzoni D, Porteri E, Guelfi D, Muiesan ML, Valentini U, Cimino A, et al Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus. Circulation 2001; 103 1238–44.

[29]  Giannattasio C, Mangoni AA, Failla M, Carugo S, Stella ML, Stefanoni P, et al Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia. Atherosclerosis 1996; 124 249–60.
Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia.Crossref | GoogleScholarGoogle Scholar |

[30]  Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D, et al Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001; 358 1400–4.
Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study.Crossref | GoogleScholarGoogle Scholar |

[31]  Hirai T, Sasayama S, Kawasaki T, Yagi S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 1989; 80 78–86.

[32]  van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, et al Association between arterial stiffness and atherosclerosis: the Rotterdam study. Stroke 2001; 32 454–60.

[33]  Heintz B, Dorr R, Gillessen T, Walkenhorst F, Krebs W, Hanrath P, et al Do arterial endothelin 1 levels affect local arterial stiffness? Am Heart J 1993; 126 987–9.
Do arterial endothelin 1 levels affect local arterial stiffness?Crossref | GoogleScholarGoogle Scholar |

[34]  Nagai Y, Metter EJ, Earley CJ, Kemper MK, Becker LC, Lakatta EG, et al Increased carotid artery intimal–medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation 1998; 98 1504–9.

[35]  O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340 14–22.
Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group.Crossref | GoogleScholarGoogle Scholar |

[36]  Virmani R, Avolio AP, Mergner WJ, Robinowitz M, Herderick EE, Cornhill JF, et al Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol 1991; 139 1119–29.

[37]  Kelly RP, Tunin R, Kass DA. Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle. Circ Res 1992; 71 490–502.

[38]  Lartaud-Idjouadiene I, Lompre AM, Kieffer P, Colas T, Atkinson J. Cardiac consequences of prolonged exposure to an isolated increase in aortic stiffness. Hypertension 1999; 34 63–9.

[39]  Watanabe H, Ohtsuka S, Kakihana M, Sugishita Y. Coronary circulation in dogs with an experimental decrease in aortic compliance. J Am Coll Cardiol 1993; 21 1497–506.
Coronary circulation in dogs with an experimental decrease in aortic compliance.Crossref | GoogleScholarGoogle Scholar |

[40]  Kass DA, Saeki A, Tunin RS, Recchia FA. Adverse influence of systemic vascular stiffening on cardiac dysfunction and adaptation to acute coronary occlusion. Circulation 1996; 93 1533–41.

[41]  Dart A, Silagy C, Dewar E, Jennings G, McNeil J. Aortic distensibility and left ventricular structure and function in isolated systolic hypertension. Eur Heart J 1993; 14 1465–70.

[42]  Dernellis J, Panaretou M. Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects. Hypertension 2005; 45 426–31.
Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects.Crossref | GoogleScholarGoogle Scholar |

[43]  Mitchell GF, Moye LA, Braunwald E, Rouleau JL, Bernstein V, Geltman EM, et al Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular Enlargement. Circulation 1997; 96 4254–60.

[44]  Chae CU, Pfeffer MA, Glynn RJ, Mitchell GF, Taylor JO, Hennekens CH. Increased pulse pressure and risk of heart failure in the elderly. JAMA 1999; 281 634–43.
Increased pulse pressure and risk of heart failure in the elderly.Crossref | GoogleScholarGoogle Scholar |

[45]  Vaccarino V, Berger AK, Abramson J, Black HR, Setaro JF, Davey JA, et al Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program. Am J Cardiol 2001; 88 980–6.
Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program.Crossref | GoogleScholarGoogle Scholar |

[46]  Kostis JB, Lawrence-Nelson J, Ranjan R, Wilson AC, Kostis WJ, Lacy CR. Association of increased pulse pressure with the development of heart failure in SHEP. Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group. Am J Hypertens 2001; 14 798–803.
Association of increased pulse pressure with the development of heart failure in SHEP. Systolic Hypertension in the Elderly (SHEP) Cooperative Research Group.Crossref | GoogleScholarGoogle Scholar |

[47]  Benetos A, Safar M, Rudnichi A, Smulyan H, Richard JL, Ducimetieere P, et al Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997; 30 1410–5.

[48]  Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study. Circulation 1999; 100 354–60.

[49]  O’Donnell CJ, Ridker PM, Glynn RJ, Berger K, Ajani U, Manson JE, et al Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians. Circulation 1997; 95 1132–7.

[50]  Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler Thromb Vasc Biol 2001; 21 2046–50.
Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age.Crossref | GoogleScholarGoogle Scholar |

[51]  Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28 1462–536.

[52]  Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003; 23 554–66.
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.Crossref | GoogleScholarGoogle Scholar |

[53]  Liang YL, Teede H, Kotsopoulos D, Shiel L, Cameron JD, Dart AM, et al Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size. Clin Sci 1998; 95 669–79.
Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size.Crossref | GoogleScholarGoogle Scholar |

[54]  Lehmann ED. Terminology for the definition of arterial elastic properties. Pathol Biol 1999; 47 656–64.

[55]  Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986; 74 1399–406.

[56]  Cameron JD, Dart AM. Exercise training increases total systemic arterial compliance in humans. Am J Physiol 1994; 266 H693–701.

[57]  Folkow B, Svanborg A. Physiology of cardiovascular aging. Physiol Rev 1993; 73 725–64.

[58]  Vasankari T, Ahotupa M, Toikka J, Mikkola J, Irjala K, Pasanen P, et al Oxidized LDL and thickness of carotid intima–media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy. Atherosclerosis 2001; 155 403–12.
Oxidized LDL and thickness of carotid intima–media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy.Crossref | GoogleScholarGoogle Scholar |

[59]  Mack WJ, LaBree L, Liu C, Selzer RH, Hodis HN. Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography. Atherosclerosis 2000; 150 371–9.
Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography.Crossref | GoogleScholarGoogle Scholar |

[60]  Lekakis JP, Papamichael CM, Cimponeriu AT, Stamatelopoulos KS, Papaioannou TG, Kanakakis J, et al Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis. Am J Cardiol 2000; 85 949–52.
Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis.Crossref | GoogleScholarGoogle Scholar |

[61]  Bots ML, Witteman JC, Grobbee DE. Carotid intima–media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta. Atherosclerosis 1993; 102 99–105.
Carotid intima–media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta.Crossref | GoogleScholarGoogle Scholar |

[62]  Bots ML, Hofman A, Grobbee DE. Common carotid intima–media thickness and lower extremity arterial atherosclerosis. The Rotterdam Study. Arterioscler Thromb 1994; 14 1885–91.

[63]  Salonen R, Tervahauta M, Salonen JT, Pekkanen J, Nissinen A, Karvonen MJ. Ultrasonographic manifestations of common carotid atherosclerosis in elderly eastern Finnish men. Prevalence and associations with cardiovascular diseases and risk factors. Arterioscler Thromb 1994; 14 1631–40.

[64]  Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, et al Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146 483–94.

[65]  Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima–media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96 1432–7.

[66]  Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, et al The role of carotid arterial intima–media thickness in predicting clinical coronary events. Ann Intern Med 1998; 128 262–9.

[67]  Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37 1236–41.

[68]  Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, et al Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002; 39 10–5.
Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study.Crossref | GoogleScholarGoogle Scholar |

[69]  Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103 987–92.

[70]  Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 1999; 99 2434–9.

[71]  Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 1998; 32 570–4.

[72]  Barenbrock M, Kosch M, Joster E, Kisters K, Rahn KH, Hausberg M. Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation. J Hypertens 2002; 20 79–84.
Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation.Crossref | GoogleScholarGoogle Scholar |

[73]  van Dijk RA, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD. Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance. Eur J Clin Invest 2001; 31 756–63.
Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance.Crossref | GoogleScholarGoogle Scholar |

[74]  Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002; 106 2085–90.
Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?Crossref | GoogleScholarGoogle Scholar |

[75]  Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, et al Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006; 113 657–63.
Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study.Crossref | GoogleScholarGoogle Scholar |

[76]  Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, Simonsick EM, et al Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005; 111 3384–90.
Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.Crossref | GoogleScholarGoogle Scholar |

[77]  Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, et al Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 2006; 113 664–70.
Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population.Crossref | GoogleScholarGoogle Scholar |

[78]  Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010; 55 1318–27.
Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis.Crossref | GoogleScholarGoogle Scholar |

[79]  O’Rourke MF. Wave travel and reflection in the arterial system. J Hypertens Suppl 1999; 17 S45–7.

[80]  Wilkinson IB, MacCallum H, Cockcroft JR, Webb DJ. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol 2002; 53 189–92.
Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo.Crossref | GoogleScholarGoogle Scholar |

[81]  Bonnet D, Aggoun Y, Szezepanski I, Bellal N, Blanche S. Arterial stiffness and endothelial dysfunction in HIV-infected children. AIDS 2004; 18 1037–41.
Arterial stiffness and endothelial dysfunction in HIV-infected children.Crossref | GoogleScholarGoogle Scholar |

[82]  Charakida M, Loukogeorgakis SP, Okorie MI, Masi S, Halcox JP, Deanfield JE, et al Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy. Antivir Ther 2009; 14 1075–9.
Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[83]  Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, et al Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005; 112 103–9.
Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[84]  McComsey GA, O’Riordan M, Hazen SL, El-Bejjani D, Bhatt S, Brennan ML, et al Increased carotid intima media thickness and cardiac biomarkers in HIV infected children. AIDS 2007; 21 921–7.
Increased carotid intima media thickness and cardiac biomarkers in HIV infected children.Crossref | GoogleScholarGoogle Scholar |

[85]  Schillaci G, De Socio GV, Pirro M, Savarese G, Mannarino MR, Baldelli F, et al Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection. Arterioscler Thromb Vasc Biol 2005; 25 2381–5.
Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection.Crossref | GoogleScholarGoogle Scholar |

[86]  Sevastianova K, Sutinen J, Westerbacka J, Ristola M, Yki-Jarvinen H. Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy. Antivir Ther 2005; 10 925–35.

[87]  Boccara F, Simon T, Lacombe K, Cohen A, Laloux B, Bozec E, et al Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy. AIDS 2006; 20 2395–8.
Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[88]  Schillaci G, De Socio GV, Pucci G, Mannarino MR, Helou J, Pirro M, et al Aortic stiffness in untreated adult patients with human immunodeficiency virus infection. Hypertension 2008; 52 308–13.
Aortic stiffness in untreated adult patients with human immunodeficiency virus infection.Crossref | GoogleScholarGoogle Scholar |

[89]  van Vonderen MG, Smulders YM, Stehouwer CD, Danner SA, Gundy CM, Vos F, et al Carotid intima–media thickness and arterial stiffness in HIV-infected patients: the role of HIV, antiretroviral therapy, and lipodystrophy. J Acquir Immune Defic Syndr 2009; 50 153–61.
Carotid intima–media thickness and arterial stiffness in HIV-infected patients: the role of HIV, antiretroviral therapy, and lipodystrophy.Crossref | GoogleScholarGoogle Scholar |

[90]  Lekakis J, Ikonomidis I, Palios J, Tsiodras S, Karatzis E, Poulakou G, et al Association of highly active antiretroviral therapy with increased arterial stiffness in patients infected with human immunodeficiency virus. Am J Hypertens 2009; 22 828–34.
Association of highly active antiretroviral therapy with increased arterial stiffness in patients infected with human immunodeficiency virus.Crossref | GoogleScholarGoogle Scholar |

[91]  Seaberg EC, Benning L, Sharrett AR, Lazar JM, Hodis HN, Mack WJ, et al Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Stroke 2010; 41 2163–70.
Association between human immunodeficiency virus infection and stiffness of the common carotid artery.Crossref | GoogleScholarGoogle Scholar |

[92]  Maggi P, Serio G, Epifani G, Fiorentino G, Saracino A, Fico C, et al Premature lesions of the carotid vessels in HIV-1-infected patients treated with protease inhibitors. AIDS 2000; 14 F123–8.
Premature lesions of the carotid vessels in HIV-1-infected patients treated with protease inhibitors.Crossref | GoogleScholarGoogle Scholar |

[93]  Depairon M, Chessex S, Sudre P, Rodondi N, Doser N, Chave JP, et al Premature atherosclerosis in HIV-infected individuals – focus on protease inhibitor therapy. AIDS 2001; 15 329–34.
Premature atherosclerosis in HIV-infected individuals – focus on protease inhibitor therapy.Crossref | GoogleScholarGoogle Scholar |

[94]  Seminari E, Pan A, Voltini G, Carnevale G, Maserati R, Minoli L, et al Assessment of atherosclerosis using carotid ultrasonography in a cohort of HIV-positive patients treated with protease inhibitors. Atherosclerosis 2002; 162 433–8.
Assessment of atherosclerosis using carotid ultrasonography in a cohort of HIV-positive patients treated with protease inhibitors.Crossref | GoogleScholarGoogle Scholar |

[95]  Mercie P, Thiebaut R, Lavignolle V, Pellegrin JL, Yvorra-Vives MC, Morlat P, et al Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima–media thickness measurement. Ann Med 2002; 34 55–63.
Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima–media thickness measurement.Crossref | GoogleScholarGoogle Scholar |

[96]  Chironi G, Escaut L, Gariepy J, Cogny A, Teicher E, Monsuez JJ, et al Brief report: carotid intima–media thickness in heavily pretreated HIV-infected patients. J Acquir Immune Defic Syndr 2003; 32 490–3.
Brief report: carotid intima–media thickness in heavily pretreated HIV-infected patients.Crossref | GoogleScholarGoogle Scholar |

[97]  Maggi P, Lillo A, Perilli F, Maserati R, Chirianni A. Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study. AIDS 2004; 18 1023–8.
Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study.Crossref | GoogleScholarGoogle Scholar |

[98]  Currier JS, Kendall MA, Zackin R, Henry WK, Alston-Smith B, Torriani FJ, et al Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure. AIDS 2005; 19 927–33.
Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure.Crossref | GoogleScholarGoogle Scholar |

[99]  Mangili A, Gerrior J, Tang AM, O’Leary DH, Polak JK, Schaefer EJ, et al Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima–media thickness and coronary artery calcium score. Clin Infect Dis 2006; 43 1482–9.
Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima–media thickness and coronary artery calcium score.Crossref | GoogleScholarGoogle Scholar |

[100]  Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, et al Increased carotid intima–media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS 2006; 20 2275–83.
Increased carotid intima–media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses.Crossref | GoogleScholarGoogle Scholar |

[101]  van Wijk JP, de Koning EJ, Cabezas MC, Joven J, Op’t Roodt J, Rabelink TJ, et al Functional and structural markers of atherosclerosis in human immunodeficiency virus-infected patients. J Am Coll Cardiol 2006; 47 1117–23.
Functional and structural markers of atherosclerosis in human immunodeficiency virus-infected patients.Crossref | GoogleScholarGoogle Scholar |

[102]  Lorenz MW, Stephan C, Harmjanz A, Staszewski S, Buehler A, Bickel M, et al Both long-term HIV infection and highly active antiretroviral therapy are independent risk factors for early carotid atherosclerosis. Atherosclerosis 2008; 196 720–6.
Both long-term HIV infection and highly active antiretroviral therapy are independent risk factors for early carotid atherosclerosis.Crossref | GoogleScholarGoogle Scholar |

[103]  Ross AC, Rizk N, O’Riordan MA, Dogra V, El-Bejjani D, Storer N, et al Relationship between inflammatory markers, endothelial activation markers, and carotid intima–media thickness in HIV-infected patients receiving antiretroviral therapy. Clin Infect Dis 2009; 49 1119–27.
Relationship between inflammatory markers, endothelial activation markers, and carotid intima–media thickness in HIV-infected patients receiving antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[104]  Fan AZ, Paul-Labrador M, Merz CN, Iribarren C, Dwyer JH. Smoking status and common carotid artery intima–medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study. BMC Cardiovasc Disord 2006; 6 42
Smoking status and common carotid artery intima–medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study.Crossref | GoogleScholarGoogle Scholar |

[105]  Kawamoto R, Ohtsuka N, Ninomiya D, Nakamura S. Association of obesity and visceral fat distribution with intima–media thickness of carotid arteries in middle-aged and older persons. Intern Med 2008; 47 143–9.
Association of obesity and visceral fat distribution with intima–media thickness of carotid arteries in middle-aged and older persons.Crossref | GoogleScholarGoogle Scholar |

[106]  van Vonderen MG, Hassink EA, van Agtmael MA, Stehouwer CD, Danner SA, Reiss P, et al Increase in carotid artery intima–media thickness and arterial stiffness but improvement in several markers of endothelial function after initiation of antiretroviral therapy. J Infect Dis 2009; 199 1186–94.
Increase in carotid artery intima–media thickness and arterial stiffness but improvement in several markers of endothelial function after initiation of antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar |

[107]  Hsue PY, Giri K, Erickson S, MacGregor JS, Younes N, Shergill A, et al Clinical features of acute coronary syndromes in patients with human immunodeficiency virus infection. Circulation 2004; 109 316–9.
Clinical features of acute coronary syndromes in patients with human immunodeficiency virus infection.Crossref | GoogleScholarGoogle Scholar |

[108]  Mercie P, Thiebaut R, Aurillac-Lavignolle V, Pellegrin JL, Yvorra-Vives MC, Cipriano C, et al Carotid intima–media thickness is slightly increased over time in HIV-1-infected patients. HIV Med 2005; 6 380–7.
Carotid intima–media thickness is slightly increased over time in HIV-1-infected patients.Crossref | GoogleScholarGoogle Scholar |

[109]  Thiebaut R, Aurillac-Lavignolle V, Bonnet F, Ibrahim N, Cipriano C, Neau D, et al Change in atherosclerosis progression in HIV-infected patients: ANRS Aquitaine Cohort, 1999–2004. AIDS 2005; 19 729–31.
Change in atherosclerosis progression in HIV-infected patients: ANRS Aquitaine Cohort, 1999–2004.Crossref | GoogleScholarGoogle Scholar |

[110]  Hadigan C, Meigs JB, Corcoran C, Rietschel P, Piecuch S, Basgoz N, et al Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. Clin Infect Dis 2001; 32 130–9.
Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy.Crossref | GoogleScholarGoogle Scholar |

[111]  Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest 2002; 82 245–55.

[112]  Rusnati M, Presta M. HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies. Angiogenesis 2002; 5 141–51.
HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies.Crossref | GoogleScholarGoogle Scholar |

[113]  Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, et al HIV Tat protein causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg 2003; 38 549–55, discussion 55–6.
HIV Tat protein causes endothelial dysfunction in porcine coronary arteries.Crossref | GoogleScholarGoogle Scholar |

[114]  Martin S, Tesse A, Hugel B, Martinez MC, Morel O, Freyssinet JM, et al Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 2004; 109 1653–9.
Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression.Crossref | GoogleScholarGoogle Scholar |

[115]  Shankar SS, Dube MP, Gorski JC, Klaunig JE, Steinberg HO. Indinavir impairs endothelial function in healthy HIV-negative men. Am Heart J 2005; 150 933.e1–e7.
Indinavir impairs endothelial function in healthy HIV-negative men.Crossref | GoogleScholarGoogle Scholar |

[116]  Baliga RS, Liu C, Hoyt DG, Chaves AA, Bauer JA. Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis. Cardiovasc Toxicol 2004; 4 199–206.
Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis.Crossref | GoogleScholarGoogle Scholar |

[117]  Sutliff RL, Dikalov S, Weiss D, Parker J, Raidel S, Racine AK, et al Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. Am J Physiol Heart Circ Physiol 2002; 283 H2363–70.

[118]  Wang X, Chai H, Yao Q, Chen C. Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction. J Acquir Immune Defic Syndr 2007; 44 493–9.
Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction.Crossref | GoogleScholarGoogle Scholar |

[119]  Dressman J, Kincer J, Matveev SV, Guo L, Greenberg RN, Guerin T, et al HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages. J Clin Invest 2003; 111 389–97.

[120]  Pirro M, Schillaci G, Savarese G, Gemelli F, Vaudo G, Siepi D, et al Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia. Eur J Clin Invest 2004; 34 335–41.
Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia.Crossref | GoogleScholarGoogle Scholar |

[121]  Schnabel R, Larson MG, Dupuis J, Lunetta KL, Lipinska I, Meigs JB, et al Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension 2008; 51 1651–7.
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.Crossref | GoogleScholarGoogle Scholar |

[122]  Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, et al Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol 2007; 99 1598–602.
Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).Crossref | GoogleScholarGoogle Scholar |

[123]  McEniery CM, Wilkinson IB. Large artery stiffness and inflammation. J Hum Hypertens 2005; 19 507–9.
Large artery stiffness and inflammation.Crossref | GoogleScholarGoogle Scholar |

[124]  Schillaci G, Pirro M, Vaudo G, Mannarino MR, Savarese G, Pucci G, et al Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension. Hypertension 2005; 45 1078–82.
Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension.Crossref | GoogleScholarGoogle Scholar |

[125]  Joshi VV, Pawel B, Connor E, Sharer L, Oleske JM, Morrison S, et al Arteriopathy in children with acquired immune deficiency syndrome. Pediatr Pathol 1987; 7 261–75.
Arteriopathy in children with acquired immune deficiency syndrome.Crossref | GoogleScholarGoogle Scholar |

[126]  Sierksma A, Muller M, van der Schouw YT, Grobbee DE, Hendriks HF, Bots ML. Alcohol consumption and arterial stiffness in men. J Hypertens 2004; 22 357–62.
Alcohol consumption and arterial stiffness in men.Crossref | GoogleScholarGoogle Scholar |

[127]  Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 1993; 88 523–33.

[128]  Knapp HR, FitzGerald GA. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med 1989; 320 1037–43.
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.Crossref | GoogleScholarGoogle Scholar |

[129]  Jennings G, Nelson L, Nestel P, Esler M, Korner P, Burton D, et al The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity. Circulation 1986; 73 30–40.

[130]  Gielen S, Schuler G, Adams V. Cardiovascular effects of exercise training: molecular mechanisms. Circulation 2010; 122 1221–38.
Cardiovascular effects of exercise training: molecular mechanisms.Crossref | GoogleScholarGoogle Scholar |

[131]  Kingwell BA, Berry KL, Cameron JD, Jennings GL, Dart AM. Arterial compliance increases after moderate-intensity cycling. Am J Physiol 1997; 273 H2186–91.

[132]  Kingwell BA, Arnold PJ, Jennings GL, Dart AM. Spontaneous running increases aortic compliance in Wistar–Kyoto rats. Cardiovasc Res 1997; 35 132–7.
Spontaneous running increases aortic compliance in Wistar–Kyoto rats.Crossref | GoogleScholarGoogle Scholar |

[133]  Kingwell BA, Sherrard B, Jennings GL, Dart AM. Four weeks of cycle training increases basal production of nitric oxide from the forearm. Am J Physiol 1997; 272 H1070–7.

[134]  Lewis TV, Dart AM, Chin-Dusting JP, Kingwell BA. Exercise training increases basal nitric oxide production from the forearm in hypercholesterolemic patients. Arterioscler Thromb Vasc Biol 1999; 19 2782–7.

[135]  Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D. The N-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 2002; 76 326–30.

[136]  Chin JP, Gust AP, Nestel PJ, Dart AM. Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans. Hypertension 1993; 21 22–8.

[137]  Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, et al Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med 2001; 344 3–10.
Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group.Crossref | GoogleScholarGoogle Scholar |

[138]  Avolio AP, Clyde KM, Beard TC, Cooke HM, Ho KK, O’Rourke MF. Improved arterial distensibility in normotensive subjects on a low salt diet. Arteriosclerosis 1986; 6 166–9.

[139]  Avolio AP, Deng FQ, Li WQ, Luo YF, Huang ZD, Xing LF, et al Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 1985; 71 202–10.

[140]  Smilde TJ, van den Berkmortel FW, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef AF. The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest 2000; 30 473–80.
The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia.Crossref | GoogleScholarGoogle Scholar |

[141]  Shige H, Dart A, Nestel P. Simvastatin improves arterial compliance in the lower limb but not in the aorta. Atherosclerosis 2001; 155 245–50.
Simvastatin improves arterial compliance in the lower limb but not in the aorta.Crossref | GoogleScholarGoogle Scholar |

[142]  Bakris GL, Bank AJ, Kass DA, Neutel JM, Preston RA, Oparil S. Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. Am J Hypertens 2004; 17 23S–30S.
Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process.Crossref | GoogleScholarGoogle Scholar |

[143]  Xu Q, Chakravorty A, Bathgate RA, Dart AM, Du XJ. Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats. Hypertension 2010; 55 1260–6.
Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats.Crossref | GoogleScholarGoogle Scholar |