A case of apparent resistance to all available antiretroviral drugs in a HIV-positive patient
Doris Chibo A C , Norman Roth B and Chris Birch AA Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street, North Melbourne, Vic. 3051, Australia.
B Prahran Market Clinic, 131 Commercial Road, South Yarra, Vic. 3141, Australia.
C Corresponding author. Email: doris.chibo@mh.org.au
Sexual Health 7(1) 82-84 https://doi.org/10.1071/SH09032
Submitted: 16 March 2009 Accepted: 24 November 2009 Published: 15 February 2010
Abstract
We describe a case of multidrug and class resistant HIV in a patient with psychological issues affecting his adherence. The complexities involved in subsequent treatment decisions when resistance interpretation algorithms are discordant are discussed.
Additional keywords: adherence factors, interpretive algorithms, multi-drug resistance, raltegravir resistance.
Acknowledgements
We thank the Signe Fransen and scientists at Monogram Biosciences for their help with performing the PhenoSense GT assay and for advice and intellectual input on the assay performance. The method for VIDRL’S in-house integrase genotyping assay is available on request.
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