Challenges, progress and strategies in the search for a cure for HIV
Christina C Chang A B and Sharon R Lewin A B C
+ Author Affiliations
- Author Affiliations
A Department of Infectious Diseases
Alfred Hospital and Monash University
Melbourne, Vic. 3000, Australia
B Centre for Biomedical Research
Burnet Institute
Melbourne, Vic. 3000, Australia
C Tel: +61 3 9076 8491
Fax: +61 3 9076 2431
Email: sharon.lewin@monash.edu
Microbiology Australia 35(2) 72-78 https://doi.org/10.1071/MA14023
Published: 5 May 2014
Abstract
The past three decades has seen a major transformation in the understanding and management of HIV infection. Effective combination antiretroviral therapy (cART) has transformed HIV from a universal death sentence to a chronic manageable disease. Current cART regimens are simpler - often only a single daily (combination) pill, but treatment must be taken life-long. Life expectancy of an HIV-infected person who receives effective cART, is now similar to a person without HIV1. The cost of long-term treatment is significant. There is now intense scientific interest in finding a cure for HIV infection or a way to allow patients to safely stop cART and remain healthy with the virus under control. A cure for HIV could either be a ‘sterilising cure’ – where there is no evidence of persistent HIV infection2,3 or a ‘functional cure’ where HIV is still present at low levels and health is maintained in the absence of cART2.
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