Saccharomyces cerevisiae as a conduit to providing insights into cellular responses using hypothesis-generating technology

Abstract

In the post-genomic era, hypothesis-generating methods of data collection have facilitated rapid advances in many areas of research. Using Saccharomyces cerevisiae in conjunction with these methods we have been able to gain insight into the ?bigger picture? of our particular research fields. This has provided the means of generating more ?informed? hypotheses that have subsequently been used in traditional hypothesis-driven research. As a result, important issues have been elucidated in the areas of flavour profile management in industrial fermentations, identification of cellular pathways involved in the biological activity of anticancer drugs and gaining a holistic view of the diverse molecular systems in which cells combat the negative effect of reactive oxygen species.