Integrated and comparative maps in livestock genomics
F. W. NicholasReprogen and CRC for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia. Email: frankn@vetsci.usyd.edu.au
Australian Journal of Experimental Agriculture 45(8) 1017-1020 https://doi.org/10.1071/EA05065
Submitted: 28 February 2005 Accepted: 17 June 2005 Published: 26 August 2005
Abstract
The creation of a single integrated map incorporating all available mapping information for an unsequenced species provides the best possible resource for meta analyses of quantitative trait loci, for a backbone on which to assemble sequence and for comparative mapping. Using a strategy encapsulated in the Location DataBase, integrated maps for cattle, sheep and pigs have been produced from all publicly-available mapping information for these livestock species. A very useful tool for comparative mapping is the Oxford grid. Of particular interest are grids comparing an integrated map from an unsequenced species with the annotated sequence map from a sequenced species. By an additional iteration of the Location DataBase approach or a variant of the Oxford-grid software, it is possible to create a virtual genome of the unsequenced species, which is a map comprising predicted locations for all loci identified in the sequenced species.
Additional keywords: comparative map, integrated map.
Acknowledgments
The results obtained from the LDB approach and from Oxford grids described in this review have been produced by considerable collaborative effort involving a number of colleagues, namely Andy Collins, Webber Liao, Matthew Hobbs, Mehar Khatkar, John Edwards and Stefan Gregory. In addition, the following colleagues contributed to the creation of integrated maps of particular species: Bill Barendse and Brian Dalrymple (cattle); Jill Maddox, Herman Raadsma and Kyall Zenger (sheep); and Yizhou Chen and Jaci Aldenhoven (pigs).
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