Biotechnologies and their potential impact on animal breeding and production: a review
H. W. Raadsma A B and I. Tammen AA ReproGen, Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, PMB3, Camden, NSW 2570, Australia.
B Corresponding author. Email: raadsma@camden.usyd.edu.au
Australian Journal of Experimental Agriculture 45(8) 1021-1032 https://doi.org/10.1071/EA05073
Submitted: 9 March 2005 Accepted: 3 June 2005 Published: 26 August 2005
Abstract
Recent developments in mammalian biotechnologies that have been driven largely by medical bioscience, offer new opportunities for livestock industries. Major impacts may be expected in the area of reproductive, genomic and cell technologies that could lead to improved animal breeding strategies or animal production and health applications. In particular, the use of advanced reproductive technologies to select animals at very early stages of life, possibly as early as a 4-day embryo, combined with genomic technologies to predict genetic merit, could lead to significantly increased rates of genetic gain. Such advanced animal breeding technologies will depend strongly on conventional quantitative genetic evaluation systems. Genetic modification in the near future will offer targeted animal improvement options for control of health and production. Long-term impact of genetic modification on animal production systems will depend on consumer acceptance, and its perception by social, environmental and animal welfare groups. However, the opportunity to develop animal products beyond conventional boundaries may prove too attractive with genetic modification eventually being accepted as the norm. The naturally synergistic effect of ex vivo transgenic modification of embryo stem cell or somatic cell lines, combined with nuclear transfer present potentially high value propositions for development of novel and high value products. Opportunities for the mass production of elite males for use in extensive animal production systems will be possible.
Aasen E, Medrano JF
(1990) Amplification of the Zfy and Zfx genes for sex identification in humans, cattle, sheep and goats. Bio/Technology 8, 1279–1281.
| Crossref | GoogleScholarGoogle Scholar |
(accessed 16 August 2005).
Faber DC,
Molina JA,
Ohlrichs CL,
van der Zwaag DF, Ferre LB
(2003) Commercialization of animal biotechnology. Therigenology 59, 125–138.
| Crossref | GoogleScholarGoogle Scholar |
(verified 20 July 2005).
Honaramooz A,
Behboodi E,
Megee SO,
Overton SA,
Galantino-Homer H,
Echelard Y, Dobrinski I
(2003) Fertility and germline transmission of donor haplotype following germ cell transplantation in immunocompetent goats. Biology of Reproduction 69, 1260–1264.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
(verified 20 July 2005).
Johnson LA,
Flook JP, Hawk HW
(1989) Sex preselection in rabbits: live births from X and Y sperm separated by DNA and cell sorting. Biology of Reproduction 41, 199–203.
| PubMed |
(accessed 16 August 2005).
Khatkar MS,
Thomson PC,
Tammen I, Raadsma HW
(2004) Quantitative trait loci mapping in dairy cattle: review and meta-analysis. Genetics, Selection, Evolution 36, 163–190.
| Crossref | GoogleScholarGoogle Scholar |
Kim SG,
Kim EH,
Lafferty CJ,
Miller LJ,
Koo HJ,
Stehman SM, Shin SJ
(2004) Use of conventional and real-time polymerase chain reaction for confirmation of Mycobacterium avium subsp. paratuberculosis in a broth-based culture system ESP II. Journal of Veterinary Diagnostic Investigation 16, 448–453.
| PubMed |
Kues WA, Niemann H
(2004) The contribution of farm animals to human health. Trends in Biotechnology 22, 286–294.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Kuroiwa Y,
Kasinathan P,
Matsushita H,
Sathiyaselan J,
Sullivan EJ,
Kakitani M,
Tomizuka K,
Ishida I, Robl JM
(2004) Sequential targeting of the genes encoding immunoglobulin-µ and prion protein in cattle. Nature Genetics 36, 775–780.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Maxwell WMC,
Evans G,
Hollinshead FK,
Bathgate R,
de Graaf SP,
Eriksson BM,
Gillan L,
Morton KM, O’Brienn JK
(2004) Integration of sperm sexing technology into the ART toolbox. Animal Reproduction Science 82–83, 79–95.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
McManus MT, Sharp PA
(2002) Gene silencing in mammals by small interferring RNAs. Nature Reviews. Genetics 3, 737–747.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Metcalfe DD
(2003) Introduction: what are the issues in addressing the allergenic potential of genetic modified food? Environmental Health Perspectives 111, 1110–1113.
| PubMed |
Meuwissen THE,
Hayes BJ, Goddard ME
(2001) Prediction of total genetics value using genome-wide dense marker maps. Genetics 157, 1819–1829.
| PubMed |
Norman HD,
Powell RL,
Wright JR, Sattler CG
(2003) Timeliness and effectiveness of progeny testing through artificial insemination. Journal of Dairy Science 86, 1513–1525.
| PubMed |
Paterson L,
DeSousa P,
Ritchie W,
King T, Wilmut I
(2003) Application of reproductive biotechnology in animals: implications and potentials. Animal Reproduction Science 79, 137–143.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Phillips PWB
(2002) Biotechnology in the global agri-food system. Trends in Biotechnology 20, 376–381.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Rohrer GA
(2004) An overview of genomics research and its impact on livestock production. Reproduction, Fertility and Development 16, 47–54.
| Crossref | GoogleScholarGoogle Scholar |
Rothschild M,
Jacobson C,
Vaske D,
Tuggle C, Wang L , et al.
(1996) The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proceedings of the National Academy of Sciences of the United States of America 93, 201–205.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Schilter B, Constable A
(2002) Regulatory control of genetically modified (GM) foods: likely developments. Toxicology Letters 127, 341–349.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Singleton WL
(2001) State of the art in artificial insemination of pigs in the United States. Theriogenology 56, 1305–1310.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Sioud M
(2004) Therapeutic siRNAs. Trends in Pharmacological Sciences 25, 22–28.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Tamashiro KL,
Wakayama T,
Akutsu H,
Yamazaki Y, Lachey JL , et al.
(2002) Cloned mice have an obese phenotype not transmitted to their offspring. Nature Medicine 8, 262–267.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Wheeler MB,
Walters EM, Clark SG
(2003) Transgenic animals in biomedicine and agriculture: outlook for the future. Animal Reproduction Science 79, 265–289.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Whitworth KM,
Agca C,
Kim JG,
Patel RV,
Springer GK,
Bivens N,
Forrester LJ,
Mathialagan N,
Green JA, Prather RS
(2005) Transcriptional profiling of pig embryogenesis by using a 15K member unigene set specific for pig reproductive tissues and embryos. Biology of Reproduction 72, 1437–1451.
| Crossref |
PubMed |
Williams D
(2003) Sows’ ears, silk purses and goats’ milk: new production methods and medical applications for silk. Medical Device Technology 14, 9–11.
Williams DA, Baum C
(2003) Gene therapy — new challenges ahead. Science 302, 400–401.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Wilmut I,
Schnieke AE,
McWhir J,
Kind AJ, Campbell KH
(1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810–813.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Young LE,
Sinclair KD, Wilmut I
(1998) Large offspring syndrome in cattle and sheep. Reviews of Reproduction 3, 155–163.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Zechendorf B
(1999) Sustainable development: how can biotechnology contribute? Trends in Biotechnology 17, 219–225.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
