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RESEARCH ARTICLE
Contents Vol 70(1)

Mo(CO)6 as a Solid CO Source in the Synthesis of Aryl/Heteroaryl Weinreb Amides under Microwave-Enhanced Condition

Raghu Ningegowda A B , Savitha Bhaskaran C , Ayyiliath M. Sajith D E , Chandrashekar Aswathanarayanappa F , M. Syed Ali Padusha C , Nanjunda Swamy Shivananju G H and Babu Shubha Priya A H
+ Author Affiliations
- Author Affiliations

A Department of Studies in Chemistry, University of Mysore, Mysuru-570006, India.

B Biocon Ltd, Hosur road, Electronic city, Bengaluru- 560100, Karnataka, India.

C Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India.

D Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India.

E Post Graduate and Research Department of Chemistry, Government College Kasargod, Kannur University, Kannur, India.

F Department of Industrial Chemistry, Jnanasahyadri, Kuvempu University, Shimoga, India.

G Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysuru –570006, Karnataka, India.

H Corresponding authors: Email: priyabs_chem@yahoo.com; nanju_chem@yahoo.com

Australian Journal of Chemistry 70(1) 44-51 https://doi.org/10.1071/CH16213
Submitted: 2 April 2016  Accepted: 17 May 2016   Published: 8 July 2016

Abstract

The facile transformation of aryl/heteroaryl nonaflates into corresponding amides via Pd-catalyzed aminocarbonylation using Mo(CO)6 as a solid CO source under microwave-enhanced condition is reported. The method was found to be tolerant with respect to a diverse range of electronically biased aryl/heteroaryl nonaflates, and exceptional yields were obtained. The optimized protocol was further extended to a diverse range of amines.


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