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RESEARCH ARTICLE
Contents Vol 68(10)

Two Efficient One-Pot Approaches for Regioselective Synthesis of New 3-Arylpyridazino[4,3-c]quinolin-5(6H)-ones

Mehdi Rimaz
+ Author Affiliations
- Author Affiliations

Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran. Email: rimaz.mehdi@gmail.com

Australian Journal of Chemistry 68(10) 1529-1534 https://doi.org/10.1071/CH15029
Submitted: 20 January 2015  Accepted: 25 March 2015   Published: 23 April 2015

Abstract

Two efficient regioselective approaches for the one-pot synthesis of 3-arylpyridazino[4,3-c]quinolin-5(6H)-one derivatives are reported, by the three-component reaction of arylglyoxal monohydrates, quinoline-2,4-diol, and hydrazinium dihydrochloride or hydrazine hydrate in ethanol and pyridine. In ethanol, the reactions were catalyzed by 1,4-diazobicyclo[2,2,2]octane. The features of both procedures are high regioselectivity, mild reaction conditions, good to high yields, and operational simplicity.


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