Synthesis, and Acid–Base and DNA-Binding Properties of a Thiophen-Appended Ruthenium Complex
Hong Luo A , Zhi-Ping Wang A B , An-Guo Zhang A and Ke-Zhi Wang A C
+ Author Affiliations
- Author Affiliations
A College of Chemistry, Beijing Normal University, Beijing 100875, China.
B Department of Chemistry, Jining Teachers College, Jining, Inner Mongolia 01200, China.
C Corresponding author. Email: kzwang@bnu.edu.cn
Australian Journal of Chemistry 64(2) 206-216 https://doi.org/10.1071/CH10316
Submitted: 1 October 2010 Accepted: 21 November 2010 Published: 15 February 2011
Abstract
2-(5-Phenylthiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (Hptip) and its RuII complex [Ru(bpy)2(Hptip)](PF6)2 (where bpy = 2,2′-bipyridine) have been synthesized and characterized by elemental analysis, 1H NMR spectroscopy, and mass spectrometry. The acid–base properties of the complex were studied by UV-visible and luminescence spectrophotometric pH titrations, and ground- and excited-state acidity ionization constants were derived. The DNA-binding properties of [Ru(bpy)2(Hptip)](PF6)2 were also investigated by means of UV-vis and emission spectroscopy, salt effects, steady-state emission quenching by [Fe(CN)6]4–, DNA competitive binding with ethidium bromide, DNA melting experiments, and viscosity measurements. Density functional theoretical calculations were also carried out in order to understand the DNA binding properties.
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