A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis
M. A. de Laat
A B and M. N. Sillence A
+ Author Affiliations
- Author Affiliations
A Biology and Environmental Science, Science and Engineering Faculty, Queensland University of Technology, 2 George Street, Gardens Point, Brisbane, Qld 4001, Australia.
B Corresponding author. Email: melody.delaat@qut.edu.au
Animal Production Science 60(18) 2111-2121 https://doi.org/10.1071/AN19491
Submitted: 30 August 2019 Accepted: 22 April 2020 Published: 16 June 2020
Journal Compilation © CSIRO 2020 Open Access CC BY-NC
Abstract
Despite the prevalence of endocrinopathic laminitis, the pharmacologic options for preventing and treating the disease are severely limited. The present review aims to discuss the spectrum of potential therapeutic agents for the condition, ranging from early experimental compounds to agents nearing registration. There are different pharmacologic targets for, and approaches to, managing laminitis. Reducing hyperinsulinaemia is central to diminishing endocrinopathic laminitis risk, and a detailed understanding of the pathophysiology of insulin dysregulation is necessary to identify pathways that can be targeted to minimise post-prandial insulin secretion and action. This area of research is advancing rapidly, with several exciting prospects, such as sodium-dependent glucose co-transporter-2 inhibitors, on the horizon for the treatment of equine metabolic dysfunction. Drugs that directly target the lamellae and aim to reduce the damage inflicted on the lamellae as part of this condition, are not yet available. Although progress in this area of laminitis therapy is slower, improved understanding of the events that lead to lamellar failure has enabled the investigation of novel drugs that aim to prevent laminitis at the site of the lesion. Finally, a brief review is included of the directions being taken in the management of the chronic and acute pain that accompanies laminitis. Medications for relieving the pain associated with laminitis are currently the most-prescribed drugs for the disease, and range from simple, affordable and thoroughly tested options, such as phenylbutazone, to newer, less-understood applications such as paracetamol and gabapentin. In the future, endocrinopathic laminitis management plans will likely take a multi-faceted approach that still hinge on effective dietary management and exercise, but also include drugs that address foot pathology, pain and underlying endocrine disturbances.
Additional keywords: equine metabolic syndrome, horse, hyperinsulinaemia, insulin dysregulation, lamellae, pituitary pars intermedia dysfunction.
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