Treatment options for anal intraepithelial neoplasia and evidence for their effectiveness

References

[1]  Jay N, Berry JM, Darragh T, Palefsky J. Treatment of diffuse high grade anal intraepithelial neoplasia with 5% fluorouracil cream. 25th International Papillomavirus Conference; May 8-14 2009; Malmo, Sweden. P19.16.

[2]  Richel O, Wieland U, de Vries HJC, Brockmeyer NH, van Noesel C, Potthoff A, et al Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in HIV positive men. Br J Dermatol 2010; 163 1301–7.
| Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in HIV positive men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXisFGltg%3D%3D&md5=62690a74bcb978a411d596d080c3d5f4CAS | 20716208PubMed |

[3]  Wieland U, Brockmeyer NH, Weissenborn SJ, Hochdorfer B, Stücker M, Swoboda J, et al Imiquimod treatment of anal intraepithelial neoplasia in HIV positive men. Arch Dermatol 2006; 142 1438–44.
| Imiquimod treatment of anal intraepithelial neoplasia in HIV positive men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlagurfK&md5=a0439ecfefe9b2438a44f1e9cc82452fCAS | 17116834PubMed |

[4]  Kreuter A, Potthoff A, Brockmeyer NH, Gamichler T, Stücker M, Altmeyer P, et al Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV infected men. J Invest Dermatol 2008; 128 2078–83.
| Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV infected men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXosVOmt7Y%3D&md5=f20e45516d85edb39f30c3278603c044CAS | 18273049PubMed |

[5]  Fox PA, Nathan M, Francis N, Singh N, Weir J, Dixon G, et al A double blind randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high grade anal intraepithelial neoplasia in HIV positive MSM on HAART, with long term follow up data including the use of open label imiquimod. AIDS 2010; 24 2331–5.
| 1:CAS:528:DC%2BC3cXhtFaqsLjN&md5=745d9a609a93057db350d5e468faa858CAS | 20729710PubMed |

[6]  Singh JC, Kuohung V, Palefsky JM. Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV positive and HIV negative men who have sex with men. J Acquir Immune Defic Syndr 2009; 52 474–9.
| 1:CAS:528:DC%2BD1MXhtlygsLnE&md5=842e52998df83eb52333e2a8f2c4aa2cCAS | 19779306PubMed |

[7]  Stier E, Goldstone S, Einstein M, Jay N, Berry M, Wilkin T, et al. Topical cidofovir for high grade perianal dysplasia in HIV positive individuals. Abstract O 19.07. 27th International Papillomavirus Conference; Sept 2011; Berlin, Germany.

[8]  Calista D. Topical cidofovir for erythroplasia of queyrat of the glans penis. Br J Dermatol 2002; 147 399–400.
| Topical cidofovir for erythroplasia of queyrat of the glans penis.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD38vhvFKntA%3D%3D&md5=d9b9101059b005ba120c1eda8af72088CAS | 12174131PubMed |

[9]  Van Pachterbeke C, Bucella D, Rozenberg S, Manigart Y, Gilles C, Larsimont D, et al Topical treatment of CIN2+ by cidofovir: results of a phase 2 double blind prospective placebo controlled study. Gynecol Oncol 2009; 115 69–74.
| Topical treatment of CIN2+ by cidofovir: results of a phase 2 double blind prospective placebo controlled study.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtVKgtrfO&md5=1f565522ccc19d6f97cde0d04724e87cCAS | 19647859PubMed |

[10]  Webber J, Fromm D. Photodynamic therapy for carcinoma in situ of the anus. Arch Surg 2004; 139 259–61.
| Photodynamic therapy for carcinoma in situ of the anus.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXis1Gqu7k%3D&md5=5e43a4c52fddeee784719dd9c9f5d1eeCAS | 15006881PubMed |

[11]  Kruijt B, van der Snoek EM, Sterenborg JCM, Amelink A, Robinson DJ. A dedicated applicator for light delivery and monitoring of PDT of anal intraepithelial neoplasia. Photodiagn Photodyn Ther 2010; 7 3–9.
| A dedicated applicator for light delivery and monitoring of PDT of anal intraepithelial neoplasia.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmtlGgsbc%3D&md5=c9ac5b9136fd0ea879bdf5015ed0c14eCAS |

[12]  van der Snoek EM, Amelink A, van der Ende ME, den Hollander JC, Kroon FP, Vriesendorp R, et al Photodynamic therapy with topical metatetrahydrochlorin is inefffective for the treatment of anal intraepithelial neoplasia grade III. J Acquir Immune Defic Syndr 2009; 52 141–3.
| Photodynamic therapy with topical metatetrahydrochlorin is inefffective for the treatment of anal intraepithelial neoplasia grade III.Crossref | GoogleScholarGoogle Scholar | 19704267PubMed |

[13]  Gattai R, Torchia D, Salvini C, Magini B, Comacchi C, Cappuccini A, et al Photodynamic therapy for the treatment of endoanal condylomata acuminata. Clin Infect Dis 2010; 51 1222–3.
| Photodynamic therapy for the treatment of endoanal condylomata acuminata.Crossref | GoogleScholarGoogle Scholar | 20964524PubMed |

[14]  Zehbe I, Richard C, Lee KF, Campbell M, Hampson L. et al. Lopinavir or zinc finger ejecting compounds as treatment for HPV related lesions? Poster P19.26. 27th International Papillomavirus Conference; Sept 2011; Berlin, Germany.

[15]  Goldstone SE, Kawalek AZ, Huyett JW. Infrared coagulator: a useful tool for treating anal squamous intraepithelial lesions. Dis Colon Rectum 2005; 48 1042–54.
| Infrared coagulator: a useful tool for treating anal squamous intraepithelial lesions.Crossref | GoogleScholarGoogle Scholar | 15868241PubMed |

[16]  Cranston RD, Hirschowitz SL, Cortina G, Moe AA. A retrospective clinical study of the treatment of high grade anal dysplasia by infrared coagulation in a population of HIV positive men who have sex with men. Int J STD AIDS 2008; 19 118–20.
| A retrospective clinical study of the treatment of high grade anal dysplasia by infrared coagulation in a population of HIV positive men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1c7ns1Wjtw%3D%3D&md5=aafc6c5f97dd68e1b51349afd086ca58CAS | 18334066PubMed |

[17]  Stier EA, Goldstone SE, Berry JM, Panther LA, Jay N, Krown SE, et al Infrared coagulator treatment of high grade anal dysplasia in HIV infected individuals. J Acquir Immune Defic Syndr 2008; 47 56–61.
| Infrared coagulator treatment of high grade anal dysplasia in HIV infected individuals.Crossref | GoogleScholarGoogle Scholar | 18156992PubMed |

[18]  Goldstone SE, Hundert JS, Huyett JW. Infrared coagulator ablation of high grade anal squamous intraepithelial lesions in HIV negative males who have sex with males. Dis Colon Rectum 2007; 50 565–75.
| Infrared coagulator ablation of high grade anal squamous intraepithelial lesions in HIV negative males who have sex with males.Crossref | GoogleScholarGoogle Scholar | 17380365PubMed |

[19]  Chang GJ, Berry JM, Jay N, Palefsky JM, Welton ML. Surgical treatment of high grade anal squamous intraepithelial lesions: a prospective study. Dis Colon Rectum 2002; 45 453–8.
| Surgical treatment of high grade anal squamous intraepithelial lesions: a prospective study.Crossref | GoogleScholarGoogle Scholar | 12006924PubMed |

[20]  Pineda CE, Berry JM, Jay N, Palefsky JM, Welton ML. High resolution anoscopy targeted surgical destruction of anal high grade squamous intraepithelial lesions: a ten year experience. Dis Colon Rectum 2008; 51 829–37.
| High resolution anoscopy targeted surgical destruction of anal high grade squamous intraepithelial lesions: a ten year experience.Crossref | GoogleScholarGoogle Scholar | 18363070PubMed |

[21]  Aynaud O, Buffet M, Roman P, Plantier F, Dupin N. Study of persistence and recurrence rates in 106 patients with condyloma and intraepithelial neoplasia after CO2 laser treatment. Eur J Dermatol 2008; 18 153–8.
| 18424374PubMed |

[22]  Nathan M, Hickey N, Mayuranathan L, Vowler SL, Singh N. Treatment of anal human papillomavirus associated disease: a long term outcome study. Int J STD AIDS 2008; 19 445–9.
| Treatment of anal human papillomavirus associated disease: a long term outcome study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1cvgsFWgtA%3D%3D&md5=eb22cfe27c17562ba75c054ab74c0567CAS | 18574114PubMed |

[23]  Salit I, Janet J, William A, Christina M. Anal dysplasia (the TRACE study): comparative effectiveness of ablative therapies. Abstract PS22–15. Proceedings of the 24th International Papillomavirus Conference; November 2007; Beijing.

[24]  Richel O, de Vries H, van Noesel C, Dijkgraaf M, Prins J. Treatment of anal intraepithelial neoplasia in HIV positive MSM: a triple arm randomised clinical trial of imiquimod, topical 5-fluorouracil and electrocautery. Abstract R1002, paper 135LB. 19th Conference on Retroviruses and Opportunistic Infections; March 2012; Seattle.

[25]  Gilson RJ, Shupack JL, Friedman-Kien AE, Conant MA, Weber JN, Nayagam AT, et al A randomised, controlled, safety study using imiquimod for the topical treatment of anogenital warts in HIV infected patients. AIDS 1999; 13 2397–404.
| A randomised, controlled, safety study using imiquimod for the topical treatment of anogenital warts in HIV infected patients.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXit1KktQ%3D%3D&md5=c16e35c9c713638cded8fc56172cfa45CAS | 10597781PubMed |