Investigating widely available substances as vaginal microbicides
Wendy HolmesMacfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, Vic. 3001, Australia; email: holmes@burnet.edu.au
Sexual Health 1(2) 73-79 https://doi.org/10.1071/SH04013
Submitted: 28 April 2004 Accepted: 21 May 2004 Published: 24 June 2004
Abstract
Microbicides to protect women from HIV are urgently needed. Several potential pharmaceutical microbicides are now undergoing obligatory clinical trials to check safety, acceptability and efficacy before approval for use. Microbicides may have side-effects and, paradoxically, their use may increase the risk of acquiring HIV. Several widely available substances have been suggested as microbicides, including substances with a low pH such as lemon juice, vinegar, soft drinks and lactobacillus dairy products. Because of the potential for harm it is important that these substances are tested before their use is widely promoted. After small scale safety and acceptability studies, their promotion needs to be evaluated as a communication intervention.
[1] McCormack S. Vaginal microbicides. Curr Opin Infect Dis 2002; 15(1): 57–62.
| PubMed | [Accessed 6 May 2004].
[3] Lard-Whiteford SL, Matecka D, O'Rear J, Yuen I, Litterst C, Reichelderfer P. Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: An update. J Acquir Immune Defic Syndr 2004; 36(1): 541–52.
| PubMed | [Verified 7 February 2004].
[16] Oyelola OO, Ayangade SO, Amole F. In vitro inhibition of sperm motility by some local mineral water drinks. Contraception 1987; 36(4): 435–40.
| Crossref | GoogleScholarGoogle Scholar | PubMed | [Accessed 30 April 2004].
[19] Potts M, Short RV. Using microbicides to fight the spread of HIV. Science 2003; 300(5618): 431A.
| Crossref | GoogleScholarGoogle Scholar | [Accessed 30 April 2004].
[22]
[23] Overman BA. The vagina as an ecologic system. Current understanding and clinical applications. J Nurse Midwifery 1993; 38(3): 146–51.
| PubMed | [Accessed 30 April 2004].
[29] Wagner AM, Wu JJ, Hansen RC, Nigg HN, Beiere RC. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am J Contact Dermat 2002; 13(1): 10–4.
| Crossref | GoogleScholarGoogle Scholar | PubMed | [Accessed on 15 August 2003].
[35] Hughes VL, Hillier SL. Microbiologic characteristics of Lactobacillus products used for colonization of the vagina. Obstet Gynecol 1990; 75(2): 244–8.
| PubMed | [Verified 7 February 2004].
[49] Elias C, Coggins C. Acceptability research on female-controlled barrier methods to prevent heterosexual transmission of HIV: Where have we been? Where are we going? J Womens Health Gend Based Med 2001; 10(2): 163–73.
| Crossref | GoogleScholarGoogle Scholar | PubMed | [Verified 7 February 2004].
[51]
[52] World Health Organization Recommendations for the development of vaginal microbicides. The International Working Group on Vaginal Microbicides. AIDS 1996; 10 1–6.
[Verified 7 February 2004].
[57]
[58]
