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STIs in MSM - long and the short of it

There is a relatively new challenge facing Sexual Health around the world; an explosion of sexually-transmitted infections (STIs) in gay and other men who have sex with men (MSM). This began about 20 years ago as highly effective treatment for HIV moved it from a universally fatal condition to a chronic manageable condition. And early data suggest rates will rise further as HIV treatments make transmission virtually impossible and pre exposure prophylaxis (PrEP) provides HIV-negative MSM with very high levels of protection against HIV.

This virtual issue highlights some of the key papers published over the last few years that seek to understand the reasons for the rises in STIs. But the virtual issue also highlights some important long-term consequences of one relatively silent STI; Human papillomavirus (HPV). MSM, and particularly those with HIV, are particularly susceptible to HPV infection and are at much higher risk of HPV-related malignancies.

This virtual issue includes papers on rising rates of specific STIs in MSM, possible explanations for the rises, ways to improve surveillance and ways to prevent STIs. It also highlights a number of key papers relating to HPV-associated malignancies and potential approaches to reducing these. Fortunately for young MSM, at least Australia’s national childhood HPV vaccination program will prevent virtually all HPV-related malignancies.

Last Updated: 14 Jun 2017

SH14153Increasing trends of syphilis among men who have sex with men in high income countries

Phillip Read, Christopher K. Fairley and Eric P. F. Chow
pp. 155-163

This paper examines the male and female syphilis notification rates in high-income countries from 2000 to 2013. The male to female ratio and proportion of cases reported as being in men who have sex with men is calculated. This paper shows that in countries with high income, there is a near universal finding of increasing rates of syphilis in MSM. It is therefore clear that no country has identified an effective method to control syphilis in this population.


This study is the latest comprehensive literature review of HIV incidence of men who have sex with men (MSM) in Mainland China. The pooled HIV incidence of Chinese MSM is 5.61/100 person years (PY), and it showed a significantly increasing trend with the change of time (3.24/100PY in 2005–2008, 5.29/100PY in 2009–2011, 5.50/100PY in 2012–2014), which reflects the severe situation of HIV incidence of Chinese MSM. HIV prevention strategies targeted at MSM should be urgently strengthened. Innovative and comprehensive intervention strategies should also be adopted, in particular for young, less educated and syphilis infected MSM subgroups.


A systematic review on hepatitis C virus transmission in gay and bisexual men shows substantially higher HCV prevalence in HIV-positive than in HIV-negative men, and injecting drug use remains the major risk factors. Of longitudinal studies, the pooled incidence remains very low in HIV-negative men. Since the early 2000s, cases-series reports increasingly point to the importance of sexual transmission of HCV in mainly HIV-positive men.

SH15236Feasibility of using GrindrTM to distribute HIV self-test kits to men who have sex with men in Los Angeles, California

A. Lina Rosengren, Emily Huang, Joseph Daniels, Sean D. Young, Robert W. Marlin and Jeffrey D. Klausner
pp. 389-392

In Los Angeles, Black and Latino men who have sex with men (MSM) have the highest rate of HIV infection, and Black MSM in LA are four times more likely than white MSM to not know they are infected with HIV. In our study, we found that it was feasible to use Grindr™, a social networking mobile phone app, to distribute HIV self-test kits, and that Grindr™ users are willing to provide personal information in exchange for HIV tests. Grindr™ users also found self-tests acceptable and easy to use. We found that social networking apps has a high potential to reach untested high-risk populations

SH16099Global travel and HIV/STI epidemics among MSM: what does the future hold?

Veronica C. Lee, Patrick S. Sullivan and Stefan D. Baral
pp. 51-58

Travel shapes the social and sexual networks and, consequently, the HIV and sexually transmissible infection (STI) acquisition risks of gay men and other men who have sex with men (MSM). Four factors associated with travel that could potentiate HIV transmission are different patterns of sexual risk behaviours during travel; the growth of online tools to meet sex partners more efficiently; the global heterogeneity of HIV strains; and the potential for diassortative mixing of men from high- and low-HIV prevalence areas. Addressing these shifting risk contexts from increased connectedness through travel and online social networking platforms requires innovation in HIV and STI prevention and treatment interventions for gay men and other MSM, and mobile applications and social networking platforms that can provide HIV-related resources and information tailored to the local risk environment and to the individual may have valuable potential.

SH16072Adapting behavioural surveillance to antiretroviral-based HIV prevention: reviewing and anticipating trends in the Australian Gay Community Periodic Surveys

Martin Holt, Toby Lea, Limin Mao, Iryna Zablotska, Evelyn Lee, John B. F. de Wit and Garrett Prestage
pp. 72-79

This article describes the adaptation of a behavioural surveillance system, the Gay Community Periodic Surveys, to the introduction of HIV pre-exposure prophylaxis (PrEP) and treatment as prevention. National trends in key indicators during 2000–15 are reviewed, showing increases in HIV testing, treatment and condomless sex with casual partners. Two scenarios anticipating the effect of PrEP highlight the need to target gay and bisexual men who engage in receptive condomless sex while also sustaining condom use at a population level.


A literature review was performed to inform the 2014 update of the Australian testing guidelines for asymptomatic men who have sex with men (MSM). Key changes include a recommendation for pharyngeal chlamydia testing, use of nucleic acid amplification tests alone for gonorrhoea testing, more frequent gonorrhoea and chlamydia testing in HIV-positive MSM, shorter time required since last void for chlamydia first-void urine collection, and the use of electronic reminders to increase STI and HIV retesting rates among MSM.

SH12070The epidemiology of anal cancer

Andrew E. Grulich, I. Mary Poynten, Dorothy A. Machalek, Fengyi Jin, David J. Templeton and Richard J. Hillman
pp. 504-508

Anal cancer is increasing in incidence in the developed world. Human papillomavirus (HPV) infection causes 80 to 90% of all cases, making it the second most strongly HPV-related cancer. HPV-16 causes around 90% of HPV positive cases. Incidence is highest among HIV positive homosexual men, in whom it is one of the most common of all cancers. Women with a history of HPV-associated cancer and transplant recipients are also at high risk.

SH15170Ability to detect high-grade squamous anal intraepithelial lesions at high resolution anoscopy improves over time

Richard J. Hillman, Manoji P. W. Gunathilake, Fengyi Jin, Winnie Tong, Andrew Field and Andrew Carr
pp. 177-181

For a given cohort, histological high-grade squamous intraepithelial lesions may be more frequently diagnosed as an anoscopist becomes more experienced with the procedure. This may effect has the potential to impact clinical service delivery and the interpretation of clinical trial data.