The changing epidemiology of Neisseria gonorrhoeae genogroups and antimicrobial resistance in Queensland, Australia, 2010–15: a case series analysis of unique Neisseria gonorrhoeae isolates
Lisa McHugh
A # * , Amalie Dyda A # , Christine Guglielmino B , Cameron Buckley C , Colleen L. Lau A D , Amy V. Jennison B , David G. Regan E , James Wood F , David Whiley C G and Ella Trembizki C
A University of Queensland, School of Public Health, Division of Medicine, Herston, Brisbane, Qld, Australia.
B Public Health Microbiology, Forensic and Scientific Services, Queensland Department of Health, Brisbane, Qld, Australia.
C The University of Queensland Centre for Clinical Health Research and Faculty of Medicine, Royal Brisbane and Women’s Hospital Campus, Brisbane, Qld, Australia.
D Research School of Population Health, Australian National University, Canberra, ACT, Australia.
E Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
F School of Population Health, University of New South Wales, Sydney, NSW, Australia.
G Pathology Queensland, Herston, Brisbane, Qld, Australia.
Handling Editor: Christopher Fairley
Sexual Health 20(4) 296-302 https://doi.org/10.1071/SH22118
Submitted: 15 July 2022 Accepted: 2 March 2023 Published: 28 March 2023
© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)
Abstract
Background: Neisseria gonorrhoeae (NG) can lead to serious reproductive and sexual health outcomes, and the annual number of NG notifications in Australia increased steadily from 10 329 in 2010 to 29 549 by 2020. Australian populations most affected are urban men who have sex with men and First Nations peoples living in remote areas, and a resurgence in urban heterosexuals has been observed since 2012.
Methods: A case series analysis of Queensland NG isolates (2010–15) exploring temporal trends and antimicrobial resistance by demographic and geographic distribution and genotype was performed. Proportions describe age, sex, strain, genogroup (NG multi-antigen sequence typing), region, swab site, antimicrobial sensitivity and isolate rates per 100 000 population. Dominant genogroups were identified.
Results: Among 3953 isolates, the median age was 25 years (IQR 20–34 years) and most (n = 2871/3915, 73%) were men. Brisbane city (68.8) and Far North Queensland (54.1) excluding Cairns showed the highest rates. Forty-six genogroups were documented, seven (G2992, G6876, G1415, G4186, G5, G1407 and G6937) comprised half of all isolates. The predominant male genogroup was G2992 (16%), and G6876 (20%) for females; G5 was predominantly male from 2010 to 2011, but equal in both sexes from 2012 to 2015.
Conclusion: Considerable temporal, geographical and demographical diversity was observed in Queensland NG isolates, which has public health implications. Certain genogroups are more transient than others, and evidence suggests bridging from male-dominant networks to heterosexual networks. Molecular surveillance can enhance tracking the epidemiology and movement of NG in Australia, highlighting the necessity of genotyping to expose potentially prevalent strains circulating in undetected or underrepresented networks by current screening methods.
Keywords: Australasia, epidemiology, genotype, gonorrhoea, isolates, molecular epidemiology, Neisseria, Queensland.
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