Increase in congenital syphilis cases and challenges in prevention in Japan, 2016–2017
Mizue Kanai A , Yuzo Arima B F , Tomoe Shimada B , Narumi Hori C , Takuya Yamagishi B , Tomimasa Sunagawa B , Yuki Tada D , Takuri Takahashi B , Makoto Ohnishi D , Tamano Matsui B and Kazunori Oishi BA Field Epidemiology Training Program, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
B Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
C Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
D Travellers’ Medical Center, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
E Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
F Corresponding author. Email: arima@niid.go.jp
Sexual Health 18(2) 197-199 https://doi.org/10.1071/SH21004
Submitted: 4 January 2021 Accepted: 13 January 2021 Published: 22 April 2021
Abstract
In Japan, the increase in congenital syphilis (CS) notifications has become a public health concern. We conducted a case series study to describe the characteristics of CS patients and their mothers. Of the 13 mothers who consented to participate, seven had regular prenatal care visits, including four who had tested negative at their first trimester syphilis screening. Only three mothers noted that their partners were tested, with all three partners being diagnosed with syphilis. Raising awareness for syphilis prevention during pregnancy, partner testing, and considering additional syphilis testing at the third trimester of pregnancy during times of increased syphilis prevalence is imperative.
Keywords: Asia, Japan, social determinants, surveillance, syphilis, women, partner testing, pregnancy, syphilis screening.
References
[1] Takahashi T, Arima Y, Yamagishi T, Nishiki S, Kanai M, Ishikane M, et al Rapid increase in reports of syphilis associated with men who have sex with women and women who have sex with men, Japan, 2012–2016. Sex Transm Dis 2018; 45 139–43.| Rapid increase in reports of syphilis associated with men who have sex with women and women who have sex with men, Japan, 2012–2016.Crossref | GoogleScholarGoogle Scholar | 29420439PubMed |
[2] National Institute of Infectious Diseases. Notification trends among syphilis cases in Japan [in Japanese]. 2021. Available online at: https://www.niid.go.jp/niid/ja/syphilis-m/syphilis-trend.html
[3] Kanai M, Arima Y, Shimada T, Hori N, Yamagishi T, Sunagawa T, et al Sociodemographic characteristics and clinical description of congenital syphilis patients and their mothers in Japan: a qualitative study, 2016. Sex Health 2018; 15 460–7.
| Sociodemographic characteristics and clinical description of congenital syphilis patients and their mothers in Japan: a qualitative study, 2016.Crossref | GoogleScholarGoogle Scholar | 30236211PubMed |
[4] Centers for Disease Control and Prevention. 2015 Sexually transmitted diseases treatment guidelines. 2015. Available online at: https://www.cdc.gov/std/tg2015/default.htm
[5] Rodrigues CS, Guimarães MD, César CC. Missed opportunities for congenital syphilis and HIV perinatal transmission prevention. Rev Saude Publica 2008; 42 851–8.
| Missed opportunities for congenital syphilis and HIV perinatal transmission prevention.Crossref | GoogleScholarGoogle Scholar | 18833384PubMed |
[6] Qin JB, Feng TJ, Yang TB, Hong FC, Lan LN, Zhang CL, et al Synthesized prevention and control of one decade for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse pregnancy outcomes in Shenzhen, South China. Eur J Clin Microbiol Infect Dis 2014; 33 2183–98.
| Synthesized prevention and control of one decade for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse pregnancy outcomes in Shenzhen, South China.Crossref | GoogleScholarGoogle Scholar | 24973132PubMed |
[7] Kakogawa J, Sadatsuki M, Nakanishi M, Minoura S. Perinatal outcomes in pregnant women with syphilis who delivered their infants at National Center for Global Health and Medicine. J Jpn Soc Perinat Neonat Med 2010; 46 1263–6. [In Japanese]
[8] National Institute of Infectious Diseases. Risk factors of congenital syphilis in Japan – National Epidemiological Surveillance of Infectious Diseases (NESID). IASR 2013; 34 113–4. [In Japanese]
[9] Wang Y, Wu M, Gong X, Zhao L, Zhao J, Zhu C, Gong C. Risk factors for congenital syphilis transmitted from mother to infant – Suzhou, China, 2011–2014. MMWR Morb Mortal Wkly Rep 2019; 68 247–50.
| Risk factors for congenital syphilis transmitted from mother to infant – Suzhou, China, 2011–2014.Crossref | GoogleScholarGoogle Scholar | 30870407PubMed |
[10] Kanai M, Arima Y, Nishiki S, Shimuta K, Itoda I, Matsui T, et al Molecular typing and macrolide resistance analyses of Treponema pallidum in heterosexuals and men who have sex with men in Japan. J Clin Microbiol 2019; 57 e01167-18
| Molecular typing and macrolide resistance analyses of Treponema pallidum in heterosexuals and men who have sex with men in Japan.Crossref | GoogleScholarGoogle Scholar | 30355761PubMed |
[11] Kojima Y, Furubayashi K, Kawahata T, Mori H, Komano J. Circulation of distinct Treponema pallidum strains in individuals with heterosexual orientation and men who have sex with men. J Clin Microbiol 2019; 57 e01148-18
| Circulation of distinct Treponema pallidum strains in individuals with heterosexual orientation and men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 30381419PubMed |
[12] Furegato M, Fifer H, Mohammed H, Simms I, Vanta P, Webb S, Foster K, et al Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis. Euro Surveill 2017; 22 17-00750
| Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis.Crossref | GoogleScholarGoogle Scholar | 29233254PubMed |
[13] Slutsker JS, Hennessy RR, Schillinger JA. Factors contributing to congenital syphilis cases – New York City, 2010–2016. MMWR Morb Mortal Wkly Rep 2018; 67 1088–93.
| Factors contributing to congenital syphilis cases – New York City, 2010–2016.Crossref | GoogleScholarGoogle Scholar | 30286056PubMed |
[14] Matsubayashi K, Kawakami K. Syphilis testing among spouses of patients with syphilis in Japan: an epidemiological study using an administrative claims database. Int J STD AIDS 2020; 31 214–20.
| Syphilis testing among spouses of patients with syphilis in Japan: an epidemiological study using an administrative claims database.Crossref | GoogleScholarGoogle Scholar | 31992144PubMed |
[15] Trivedi S, Williams C, Torrone E, Kidd S. National trends and reported risk factors among pregnant women with syphilis in the United States, 2012–2016. Obstet Gynecol 2019; 133 27–32.
| National trends and reported risk factors among pregnant women with syphilis in the United States, 2012–2016.Crossref | GoogleScholarGoogle Scholar | 30531570PubMed |