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EDITORIAL

Getting pre-exposure prophylaxis (PrEP) to the people: opportunities, challenges and examples of successful health service models of PrEP implementation

Iryna B. Zablotska A F , Jared M. Baeten B , Nittaya Phanuphak C , Sheena McCormack D and Jason Ong E
+ Author Affiliations
- Author Affiliations

A Faculty of Medicine and Health, The University of Sydney, 162 Marsden Street, Parramatta, NSW 2150, Australia.

B Schools of Medicine and Public Health, University of Washington, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA.

C The Thai Red Cross AIDS Research Centre, Bangkok, 104 Rajdumri Road, Pathumwan, Bangkok 10330, Thailand.

D MRC Clinical Trials Unit at UCL, University College London, 90 High Holborn, London WC1V 6LJ, UK.

E London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

F Corresponding author. Email: iryna.zablotska@sydney.edu.au

Sexual Health 15(6) 481-484 https://doi.org/10.1071/SH18182
Submitted: 25 September 2018  Accepted: 4 October 2018   Published: 29 November 2018

Abstract

Pre-exposure prophylaxis (PrEP) with antiretrovirals could prevent millions of infections, yet effective strategies to get PrEP delivered are just being defined. This editorial introduces a series of 17 articles which form a special issue of Sexual Health focused on the opportunities and challenges for health service providers engaged in PrEP prescribing. All pieces presented here share useful lessons from PrEP pioneers; more than that, they should serve as catalysts to accelerate PrEP implementation around the world.


References

[1]  Fonner VA, Dalglish SL, Kennedy CE, Baggaley R, O’Reilly KR, Koechlin FM, Rodolph M, Hodges-Mameletzis I, Grant RM. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations. AIDS 2016; 30 1973–83.
Effectiveness and safety of oral HIV preexposure prophylaxis for all populations.Crossref | GoogleScholarGoogle Scholar |

[2]  United Nations General Assembly. Political declaration on HIV and AIDS: on the fast-track to accelerate the fight against HIV and to end the AIDS epidemic by 2030. Geneva: UNAIDS; 2016. Available online at: http://www.unaids.org/en/resources/documents/2016/2016-political-declaration-HIV-AIDS [verified 28 July 2016].

[3]  United Nations Development Programme (UNDP). Sustainable Development Goals. Sustainable development goal number 3. Ensure healthy lives and promote well-being for all ages. AIDS-related target. Geneva: UNDP; 2017. Available online at: https://www.un.org/sustainabledevelopment/health/ [verified 17 October 2018].

[4]  The Joint United Nations Programme on HIV/AIDS (UNAIDS). UNAIDS fast track approach. November 2014 (document number JC 2686). Geneva: UNAIDS; 2014. Available online at: http://www.unaids.org/sites/default/files/media_asset/JC2686_WAD2014report_en.pdf [verified 17 October 2018].

[5]  The Joint United Nations Programme on HIV/AIDS (UNAIDS). 2016 update on pre-exposure prophylaxis (PrEP). 31 October 2016. Geneva: UNAIDS; 2016. Available online at: http://www.unaids.org/en/resources/presscentre/featurestories/2016/october/20161031_PrEP [verified 15 June 2017].

[6]  Coleman R. Setting the scene, setting the targets. The Joint United Nations Programme on HIV/AIDS prevention targets of 2016 and estimating global pre-exposure prophylaxis targets. Sex Health 2018; 15 485–488.

[7]  The Joint United Nations Programme on HIV/AIDS (UNAIDS). Implementation of the HIV prevention 2020 roadmap. First progress report 2018. Geneva: UNAIDS; 2018. Available online at: http://www.unaids.org/sites/default/files/media_asset/jc2927_hiv-prevention-2020-road-map-first-progress-report_en.pdf [verified 15 September 2018].

[8]  World Health Organization (WHO). Tool to set and monitor targets for HIV prevention, diagnosis, treatment and care for key populations. Geneva: WHO; 2015. Available online at: http://apps.who.int/iris/bitstream/handle/10665/177992/9789241508995_eng.pdf?sequenc170 [verified 15 September 2018].

[9]  World Health Organization (WHO). Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV (September 2015). Geneva: WHO; 2015. Available online at: http://www.who.int/hiv/pub/guidelines/earlyrelease-arv/en [verified 17 October 2018].

[10]  Hodges-Mameletzis I, Dalal S, Msimanga-Radebe B, Rodolph M, Baggaley R. Going global: the adoption of the World Health Organization’s enabling recommendation on oral pre-exposure prophylaxis for HIV. Sex Health 2018; 15 489–500.

[11]  Davies N, Heffron R. Global and national guidance for the use of pre-exposure prophylaxis during peri-conception, pregnancy and breastfeeding. Sex Health 2018; 15 501–512.

[12]  Reyniers T, Vuylsteke B, Pirotte B, Hoornenborg E, Bil JP, Wouters K, Laga M, Nöstlinger C. Physicians’ preparedness for pre-exposure prophylaxis: results of an online survey in Belgium. Sex Health 2018; 15 606–611.

[13]  Wood BR, Mann MS, Martinez-Paz N, Unruh KT, Annese M, Spach DH, Scott JD, Stekler JD. Project ECHO: telementoring to educate and support prescribing of HIV pre-exposure prophylaxis by community medical providers. Sex Health 2018; 15 601–605.

[14]  Needleman R, Chow EPF, Towns JM, Cornelisse VJ, Yang TZT, Chen MY, Bradshaw CS, Fortune R, Fairley CK. Access to sexual health services after the rapid roll out of the launch of pre-exposure prophylaxis for HIV in Melbourne, Australia: a retrospective cross-sectional analysis. Sex Health 2018; 15 528–532.

[15]  Girometti N, McCormack S, Devitt E, Gedela K, Nwokolo N, Patel S, Suchak T, McOwan A, Whitlock G. Evolution of a pre-exposure prophylaxis (PrEP) service in a community-located sexual health clinic: concise report of the PrEPxpress. Sex Health 2018; 15 598–600.

[16]  Schmidt H-MA, McIver R, Houghton R, Selvey C, McNulty A, Varma R, Grulich AE, Holden J. Nurse-led pre-exposure prophylaxis: a non-traditional model to provide HIV prevention in a resource-constrained, pragmatic clinical trial. Sex Health 2018; 15 595–597.

[17]  Tung EL, Thomas A, Eichner A, Shalit P. Implementation of a community pharmacy-based pre-exposure prophylaxis service: a novel model for pre-exposure prophylaxis care. Sex Health 2018; 15 556–561.

[18]  Phanuphak N, Sungsing T, Jantarapakde J, Pengnonyang S, Trachunthong D, Mingkwanrungruang P, Sirisakyot W, Phiayura P, Seekaew P, Panpet P, Meekrua P, Praweprai N, Suwan F, Sangtong S, Brutrat P, Wongsri T, Rattakittvijun Na Nakorn P, Mills S, Avery M, Vannakit R, Phanuphak P. Princess PrEP program: the first key population-led model to deliver pre-exposure prophylaxis to key populations by key populations in Thailand. Sex Health 2018; 15 542–555.

[19]  Schwartz K, Ferrigno B, Vining S, Gomez A, Briedenhann E, Gardiner E, Jeckonia P, Torjesen K. PrEP Communications Accelerator: a digital demand creation tool for sub-Saharan Africa. Sex Health 2018; 15 570–577.

[20]  Sharpe JD, Kamara MT. A systematic evalution of mobile apps to improve the update of and adherence to HIV pre-exposure prophylaxis. Sex Health 2018; 15 587–594.

[21]  Sullivan PS, Siegler AJ. Getting pre-exposure prophylaxis (PrEP) to the people: opportunities, challenges and emerging models of PrEP implementation. Sex Health 2018; 15 522–527.

[22]  Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kakia A, Odoyo J, Mucunguzi A, et al Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012; 367 399–410.
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.Crossref | GoogleScholarGoogle Scholar |

[23]  Masyuko S, Mukui I, Njathi O, Kimani M, Oluoch P, Wamicwe J, Mutegi J, Njogo S, Anyona M, Muchiri P, Maikweki L, Musyoki H, Bahati P, Kyongo J, Marwa T, Irungu E, Kiragu M, Kioko U, Ogando J, Were D, et al Pre-exposure prophylaxis rollout in a national public sector program: the Kenyan case study. Sex Health 2018; 15 578–586.

[24]  Hood JE, Eljallad T, Abad J, Connolly M, Heumann C, Fritz J, Roach M, Lukomski D, Golden MR. Getting pre-exposure prophylaxis to high-risk transgender women: lessons from Detroit, USA. Sex Health 2018; 15 562–569.

[25]  Tan RKJ, Teo AKJ, Kaur N, Harrison-Quintana J, I-Cheng Chen M, Wong CS. Cost and anonymity as factors for the effective implementation of pre-exposure prophylaxis: an observational study among gay, bisexual and other men who have sex with men in Singapore. Sex Health 2018; 15 533–541.

[26]  Dunbar MS, Kripke K, Haberer J, Castor D, Dalal S, Mukoma W, Mullick S, Patel P, Reed J, Subedar H, Were D, Warren M, Torjesen K. Understanding and measuring uptake and coverage of oral pre-exposure prophylaxis delivery among adolescent girls and young women in sub-Saharan Africa. Sex Health 2018; 15 513–521.