HIV incidence among gay men and other men who have sex with men in 2020: where is the epidemic heading?
Shauna Stahlman A F , Carrie Lyons A , Patrick S. Sullivan B , Kenneth H. Mayer C D , Sean Hosein E , Chris Beyrer A and Stefan D. Baral AA Johns Hopkins Bloomberg School of Public Health, Center for Public Health and Human Rights, Department of Epidemiology, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
B Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA.
C Fenway Health, The Fenway Institute, 1340 Boylston Street, 8th floor, Boston, MA 02215, USA.
D Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
E CATIE (Canada’s AIDS Treatment Information Exchange), 555 Richmond Street West, Suite 505, Box 1104, Toronto, ON M5V 3B1, Canada.
F Corresponding author. Email: sstahlm1@jhu.edu
Sexual Health 14(1) 5-17 https://doi.org/10.1071/SH16070
Submitted: 30 April 2016 Accepted: 7 June 2016 Published: 5 August 2016
Journal Compilation © CSIRO Publishing 2017 Open Access CC BY-NC-ND
Abstract
The goal to effectively prevent new HIV infections among gay, bisexual, and other men who have sex with men (MSM) is more challenging now than ever before. Despite declines in the late 1990s and early 2000s, HIV incidence among MSM is now increasing in many low- and high-income settings including the US, with young, adolescent, and racial/ethnic minority MSM being among those at highest risk. Potentiating HIV risks across all settings are individual-, network-, and structural-level factors such as stigma and lack of access to pre-exposure prophylaxis (PrEP) and antiretroviral treatment as prevention. To make a sustained impact on the epidemic, a concerted effort must integrate all evidence-based interventions that will most proximally decrease HIV acquisition and transmission risks, together with structural interventions that will support improved coverage and retention in care. Universal HIV treatment, increased access to HIV testing, and daily oral PrEP have emerged as integral to the prevention of HIV transmission, and such efforts should be immediately expanded for MSM and other populations disproportionately affected by HIV. Respect for human rights and efforts to combat stigma and improve access to prevention services are needed to change the trajectory of the HIV pandemic among MSM.
References
[1] UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2013. Geneva: Joint United Nations Programme on HIV/AIDS; 2013.[2] MacAllister J, Sherwood J, Galjour J, Robbins S, Zhao J, Dam K, et al A comprehensive review of available epidemiologic and HIV service data for female sex workers, men who have sex with men, and people who inject drugs in select West and Central African countries. J Acquir Immune Defic Syndr 2015; 68 S83–90.
| A comprehensive review of available epidemiologic and HIV service data for female sex workers, men who have sex with men, and people who inject drugs in select West and Central African countries.Crossref | GoogleScholarGoogle Scholar | 25723995PubMed |
[3] UNAIDS. 90–90–90 - An ambitious treatment target to help end the AIDS epidemic; 2014. Available online at: http://www.unaids.org/en/resources/documents/2014/90-90-90 [verified 2 June 2016].
[4] Ayala G, Makofane K, Santos G-M, Arreola S, Hebert P, Thomann M, et al HIV treatment cascades that leak: correlates of drop-off from the HIV care continuum among men who have sex with men worldwide. J AIDS Clin Res 2014; 5 331
| HIV treatment cascades that leak: correlates of drop-off from the HIV care continuum among men who have sex with men worldwide.Crossref | GoogleScholarGoogle Scholar |
[5] Holland CE, Papworth E, Billong SC, Tamoufe U, LeBreton M, Kamla A, et al Antiretroviral treatment coverage for men who have sex with men and female sex workers living with HIV in Cameroon. J Acquir Immune Defic Syndr 2015; 68 S232–40.
| Antiretroviral treatment coverage for men who have sex with men and female sex workers living with HIV in Cameroon.Crossref | GoogleScholarGoogle Scholar | 25723989PubMed |
[6] Beyrer C, Baral SD, Weir BW, Curran JW, Chaisson RE, Sullivan PS. A call to action for concentrated HIV epidemics. Curr Opin HIV AIDS 2014; 9 95–100.
| A call to action for concentrated HIV epidemics.Crossref | GoogleScholarGoogle Scholar | 24499807PubMed |
[7] Beyrer C, Baral SD, van Griensven F, Goodreau SM, Chariyalertsak S, Wirtz AL, et al Global epidemiology of HIV infection in men who have sex with men. Lancet 2012; 380 367–77.
| Global epidemiology of HIV infection in men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 22819660PubMed |
[8] Baral S, Sifakis F, Cleghorn F, Beyrer C. Elevated risk for HIV infection among men who have sex with men in low- and middle-income countries 2000–2006: a systematic review. PLoS Med 2007; 4 e339
| Elevated risk for HIV infection among men who have sex with men in low- and middle-income countries 2000–2006: a systematic review.Crossref | GoogleScholarGoogle Scholar | 18052602PubMed |
[9] Centers for Disease Control and Prevention. HIV infections attributed to male-to-male sexual contact - metropolitan statistical areas, United States and Puerto Rico, 2010. MMWR Morb Mortal Wkly Rep 2012; 61 962–6.
| 23190569PubMed |
[10] Beyrer C, Sullivan P, Sanchez J, Baral SD, Collins C, Wirtz AL, et al The increase in global HIV epidemics in MSM. AIDS 2013; 27 2665–78.
| The increase in global HIV epidemics in MSM.Crossref | GoogleScholarGoogle Scholar | 23842129PubMed |
[11] Feng Y, Bu K, Li M, Zhang X, Jin S, Wang L. [Meta-analysis of HIV infection incidence and risk factors among men who have sex with men in China]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2015; 36 752–8. [in Chinese]
| 26564708PubMed |
[12] Zhang M, Chu Z, Wang H, Xu J, Lu C, Shang H. A rapidly increasing incidence of HIV and syphilis among men who have sex with men in a major city of China. AIDS Res Hum Retroviruses 2011; 27 1139–40.
| A rapidly increasing incidence of HIV and syphilis among men who have sex with men in a major city of China.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1ShsbbP&md5=623ad1fe55358881ec54bf32fc1e729cCAS | 21388334PubMed |
[13] Peng Z, Yang H, Norris J, Chen X, Huan X, Yu R, et al HIV incidence and predictors associated with retention in a cohort of men who have sex with men in Yangzhou, Jiangsu Province, China. PLoS One 2012; 7 e52731
| HIV incidence and predictors associated with retention in a cohort of men who have sex with men in Yangzhou, Jiangsu Province, China.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXnsVynsA%3D%3D&md5=2f2f11a2bbb7770e3de586ba7d825a5bCAS | 23285172PubMed |
[14] Sanders EJ, Graham SM, Okuku HS, van der Elst EM, Muhaari A, Davies A, et al HIV-1 infection in high risk men who have sex with men in Mombasa, Kenya. AIDS 2007; 21 2513–20.
| HIV-1 infection in high risk men who have sex with men in Mombasa, Kenya.Crossref | GoogleScholarGoogle Scholar | 18025888PubMed |
[15] van Griensven F, Varangrat A, Wimonsate W, Tanpradech S, Kladsawad K, Chemnasiri T, et al Trends in HIV prevalence, estimated HIV incidence, and risk behavior among men who have sex with men in Bangkok, Thailand, 2003–2007. J Acquir Immune Defic Syndr 2010; 53 234–9.
| Trends in HIV prevalence, estimated HIV incidence, and risk behavior among men who have sex with men in Bangkok, Thailand, 2003–2007.Crossref | GoogleScholarGoogle Scholar | 19901844PubMed |
[16] Price MA, Rida W, Mwangome M, Mutua G, Middelkoop K, Roux S, et al Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth. J Acquir Immune Defic Syndr 2012; 59 185–93.
| Identifying at-risk populations in Kenya and South Africa: HIV incidence in cohorts of men who report sex with men, sex workers, and youth.Crossref | GoogleScholarGoogle Scholar | 22227488PubMed |
[17] Phillips AN, Cambiano V, Nakagawa F, Brown AE, Lampe F, Rodger A, et al Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic. PLoS One 2013; 8 e55312
| Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXjsVakur8%3D&md5=83851cff4ed059a323925799b2198a2cCAS | 23457467PubMed |
[18] Beyrer C, Baral SD, Walker D, Wirtz AL, Johns B, Sifakis F. The expanding epidemics of HIV type 1 among men who have sex with men in low- and middle-income countries: diversity and consistency. Epidemiol Rev 2010; 32 137–51.
| The expanding epidemics of HIV type 1 among men who have sex with men in low- and middle-income countries: diversity and consistency.Crossref | GoogleScholarGoogle Scholar | 20573756PubMed |
[19] Baral SD, Grosso A, Holland C, Papworth E. The epidemiology of HIV among men who have sex with men in countries with generalized HIV epidemics. Curr Opin HIV AIDS 2014; 9 156–67.
| The epidemiology of HIV among men who have sex with men in countries with generalized HIV epidemics.Crossref | GoogleScholarGoogle Scholar | 24445371PubMed |
[20] Sullivan PS, Jones JS, Baral SD. The global north: HIV epidemiology in high-income countries. Curr Opin HIV AIDS 2014; 9 199–205.
| The global north: HIV epidemiology in high-income countries.Crossref | GoogleScholarGoogle Scholar | 24445370PubMed |
[21] Lou J, Blevins M, Ruan Y, Vermund SH, Tang S, Webb GF, et al Modeling the impact on HIV incidence of combination prevention strategies among men who have sex with men in Beijing, China. PLoS One 2014; 9 e90985
| Modeling the impact on HIV incidence of combination prevention strategies among men who have sex with men in Beijing, China.Crossref | GoogleScholarGoogle Scholar | 24626165PubMed |
[22] May RM, Anderson RM. Transmission dynamics of HIV infection. Nature 1987; 326 137–42.
| Transmission dynamics of HIV infection.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL2s7ksVKgsA%3D%3D&md5=aba41602a7c8ffa4aba5f6745419a0b9CAS | 3821890PubMed |
[23] Winetrobe H, Rice E, Bauermeister J, Petering R, Holloway IW. Associations of unprotected anal intercourse with Grindr-met partners among Grindr-using young men who have sex with men in Los Angeles. AIDS Care 2014; 26 1303–8.
| Associations of unprotected anal intercourse with Grindr-met partners among Grindr-using young men who have sex with men in Los Angeles.Crossref | GoogleScholarGoogle Scholar | 24754563PubMed |
[24] Beymer MR, Weiss RE, Bolan RK, Rudy ET, Bourque LB, Rodriguez JP, et al Sex on demand: geosocial networking phone apps and risk of sexually transmitted infections among a cross-sectional sample of men who have sex with men in Los Angeles County. Sex Transm Infect 2014; 90 567–72.
| Sex on demand: geosocial networking phone apps and risk of sexually transmitted infections among a cross-sectional sample of men who have sex with men in Los Angeles County.Crossref | GoogleScholarGoogle Scholar | 24926041PubMed |
[25] Stahlman S, Grosso A, Ketende S, Mothopeng T, Taruberekera N, Nkonyana J, et al Characteristics of men who have sex with men in southern Africa who seek sex online: a cross-sectional study. J Med Internet Res 2015; 17 e129
| Characteristics of men who have sex with men in southern Africa who seek sex online: a cross-sectional study.Crossref | GoogleScholarGoogle Scholar | 26006788PubMed |
[26] Ko NY, Tseng PC, Huang YC, Chen YC, Hsu ST. Seeking sex partners through the internet and mobile phone applications among men who have sex with men in Taiwan. AIDS Care 2016; 28 927–31.
| Seeking sex partners through the internet and mobile phone applications among men who have sex with men in Taiwan.Crossref | GoogleScholarGoogle Scholar | 26754350PubMed |
[27] Bien CH, Best JM, Muessig KE, Wei C, Han L, Tucker JD. Gay apps for seeking sex partners in China: implications for MSM sexual health. AIDS Behav 2015; 19 941–6.
| Gay apps for seeking sex partners in China: implications for MSM sexual health.Crossref | GoogleScholarGoogle Scholar | 25572834PubMed |
[28] Johnson AS, Hall HI, Hu X, Lansky A, Holtgrave DR, Mermin J. Trends in diagnoses of HIV infection in the United States, 2002–2011. JAMA 2014; 312 432–4.
| Trends in diagnoses of HIV infection in the United States, 2002–2011.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXns1Whur8%3D&md5=89eb6c48e3634113a0a3eb5f2f7add3cCAS | 25038362PubMed |
[29] Centers for Disease Control and Prevention. HIV Incidence 2010. Available online at: http://www.cdc.gov/hiv/statistics/surveillance/incidence.html [verified 20 January 2016].
[30] Rosenberg ES, Millett GA, Sullivan PS, Del Rio C, Curran JW. Understanding the HIV disparities between black and white men who have sex with men in the USA using the HIV care continuum: a modeling study. Lancet HIV 2014; 1 e112–8.
| Understanding the HIV disparities between black and white men who have sex with men in the USA using the HIV care continuum: a modeling study.Crossref | GoogleScholarGoogle Scholar | 25530987PubMed |
[31] Sullivan PS, Rosenberg ES, Sanchez TH, Kelley CF, Luisi N, Cooper HL, et al Explaining racial disparities in HIV incidence in black and white men who have sex with men in Atlanta, GA: a prospective observational cohort study. Ann Epidemiol 2015; 25 445–54.
| Explaining racial disparities in HIV incidence in black and white men who have sex with men in Atlanta, GA: a prospective observational cohort study.Crossref | GoogleScholarGoogle Scholar | 25911980PubMed |
[32] Millett GA, Peterson JL, Flores SA, Hart TA, Jeffries WL, Wilson PA, et al Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis. Lancet 2012; 380 341–8.
| Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis.Crossref | GoogleScholarGoogle Scholar | 22819656PubMed |
[33] Public Health Agency of Canada. HIV/AIDS epi updates: national HIV prevalence and incidence estimates for 2011 Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, 2014. Available online at: http://www.catie.ca/en/resources/hivaids-epi-update-chapter-1-national-hiv-prevalence-and-incidence-estimates-2011-0 [verified 2 June 2016].
[34] The Kirby Institute. HIV, viral hepatitis and sexually transmissible infections in Australia: annual surveillance report. Sydney: The Kirby Institute, UNSW Australia. Available online at: http://kirby.unsw.edu.au/surveillance/2015-annual-surveillance-report-hiv-viral-hepatitis-stis [verified 2 June 2016].
[35] Desai S, Croxford S, Brown AE, Mitchell H, Hughes G, Delpech V. An overview of the HIV epidemic among men who have sex with men in the United Kingdom, 1999–2013. Euro Commun Dis Bull 2015; 20 1–10.
[36] Castillo R, Konda KA, Leon SR, Silva-Santisteban A, Salazar X, Klausner JD, et al HIV and sexually transmitted infection incidence and associated risk factors among high-risk MSM and male-to-female transgender women in Lima, Peru. J Acquir Immune Defic Syndr 2015; 69 567–75.
| HIV and sexually transmitted infection incidence and associated risk factors among high-risk MSM and male-to-female transgender women in Lima, Peru.Crossref | GoogleScholarGoogle Scholar | 25950207PubMed |
[37] Janiec J, Haar K, Spiteri G, Likatavicius G, Van de Laar M, Amato-Gauci AJ. Surveillance of human immunodeficiency virus suggests that younger men who have sex with men are at higher risk of infection, European Union, 2003 to 2012. Euro Commun Dis Bull 2013; 18 20644
| Surveillance of human immunodeficiency virus suggests that younger men who have sex with men are at higher risk of infection, European Union, 2003 to 2012.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2c3jvFaqtQ%3D%3D&md5=187e56c52ba8f05b7b8f469d23341e8aCAS |
[38] Wright NMJ, Tompkins CNE. Supervised injecting centres. BMJ 2004; 328 100–2.
| Supervised injecting centres.Crossref | GoogleScholarGoogle Scholar |
[39] European Monitoring Centre for Drugs and Drug Addition. Drug consumption rooms: an overview of provision and evidence 2015. Available online at: http://www.emcdda.europa.eu/topics/pods/drug-consumption-rooms [verified 2 June 2016].
[40] DeBeck K, Kerr T, Bird L, Zhang R, Marsh D, Tyndall M, et al Injection drug use cessation and use of North America’s first medically supervised safer injecting facility. Drug Alcohol Depend 2011; 113 172–6.
| Injection drug use cessation and use of North America’s first medically supervised safer injecting facility.Crossref | GoogleScholarGoogle Scholar | 20800976PubMed |
[41] Baggaley RF, White RG, Boily MC. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol 2010; 39 1048–63.
| HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention.Crossref | GoogleScholarGoogle Scholar | 20406794PubMed |
[42] Glick SN, Morris M, Foxman B, Aral SO, Manhart LE, Holmes KK, et al A comparison of sexual behavior patterns among men who have sex with men and heterosexual men and women. J Acquir Immune Defic Syndr 2012; 60 83–90.
| A comparison of sexual behavior patterns among men who have sex with men and heterosexual men and women.Crossref | GoogleScholarGoogle Scholar | 22522237PubMed |
[43] van Griensven F, Varangrat A, Wimonsate W, Tanpradech S, Kladsawad K, Chemnasiri T, et al Trends in HIV prevalence, estimated HIV incidence, and risk behavior among men who have sex with men in Bangkok, Thailand, 2003–2007. J Acquir Immune Defic Syndr 2010; 53 234–9.
| Trends in HIV prevalence, estimated HIV incidence, and risk behavior among men who have sex with men in Bangkok, Thailand, 2003–2007.Crossref | GoogleScholarGoogle Scholar | 19901844PubMed |
[44] van Griensven F, Thienkrua W, McNicholl J, Wimonsate W, Chaikummao S, Chonwattana W, et al Evidence of an explosive epidemic of HIV infection in a cohort of men who have sex with men in Thailand. AIDS 2013; 27 825–32.
| Evidence of an explosive epidemic of HIV infection in a cohort of men who have sex with men in Thailand.Crossref | GoogleScholarGoogle Scholar | 23169330PubMed |
[45] Chariyalertsak S, Kosachunhanan N, Saokhieo P, Songsupa R, Wongthanee A, Chariyalertsak C, et al HIV incidence, risk factors, and motivation for biomedical intervention among gay, bisexual men, and transgender persons in Northern Thailand. PLoS One 2011; 6 e24295
| HIV incidence, risk factors, and motivation for biomedical intervention among gay, bisexual men, and transgender persons in Northern Thailand.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXht1ChsbzP&md5=3008426bb3ba521988d60d9a7f8f3023CAS | 21931673PubMed |
[46] Zhang L, Chow EPF, Wilson DP. Distributions and trends in sexual behaviors and HIV incidence among men who have sex with men in China. BMC Public Health 2012; 12 546
| Distributions and trends in sexual behaviors and HIV incidence among men who have sex with men in China.Crossref | GoogleScholarGoogle Scholar | 22828173PubMed |
[47] Garofalo R, Hotton AL, Kuhns LM, Gratzer B, Mustanski B. Incidence of HIV infection and sexually transmitted infections and related risk factors among very young men who have sex with men. J Acquir Immune Defic Syndr 2016; 72 79–86.
| Incidence of HIV infection and sexually transmitted infections and related risk factors among very young men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 26745827PubMed |
[48] Bedoya CA, Mimiaga MJ, Beauchamp G, Donnell D, Mayer KH, Safren SA. Predictors of HIV transmission risk behavior and seroconversion among Latino men who have sex with men in Project EXPLORE. AIDS Behav 2012; 16 608–17.
| Predictors of HIV transmission risk behavior and seroconversion among Latino men who have sex with men in Project EXPLORE.Crossref | GoogleScholarGoogle Scholar | 21390540PubMed |
[49] Mustanski BS, Newcomb ME, Bois SND, Garcia SC, Grov C. HIV in young men who have sex with men: a review of epidemiology, risk, and protector factors, and interventions. J Sex Res 2011; 48 218–53.
| HIV in young men who have sex with men: a review of epidemiology, risk, and protector factors, and interventions.Crossref | GoogleScholarGoogle Scholar | 21409715PubMed |
[50] Sifakis F, Hylton JB, Flynn C, Solomon L, Mackellar DA, Valleroy LA, et al Racial disparities in HIV incidence among young men who have sex with men: the Baltimore Young Men’s Survey. J Acquir Immune Defic Syndr 2007; 46 343–8.
| Racial disparities in HIV incidence among young men who have sex with men: the Baltimore Young Men’s Survey.Crossref | GoogleScholarGoogle Scholar | 17846561PubMed |
[51] Prejean J, Tang T, Hall HI. HIV diagnoses and prevalence in the southern region of the United States, 2007–2010. J Community Health 2013; 38 414–26.
| HIV diagnoses and prevalence in the southern region of the United States, 2007–2010.Crossref | GoogleScholarGoogle Scholar | 23179388PubMed |
[52] Stall R, Duran L, Wisniewski SR, Friedman MS, Marshal MP, McFarland W, et al Running in place: implications of HIV incidence estimates among urban men who have sex with men in the United States and other industrialized countries. AIDS Behav 2009; 13 615–29.
| Running in place: implications of HIV incidence estimates among urban men who have sex with men in the United States and other industrialized countries.Crossref | GoogleScholarGoogle Scholar | 19205867PubMed |
[53] Millett GA, Peterson JL, Wolitski RJ, Stall R. Greater risk for HIV infection of black men who have sex with men: a critical literature review. Am J Public Health 2006; 96 1007–19.
| Greater risk for HIV infection of black men who have sex with men: a critical literature review.Crossref | GoogleScholarGoogle Scholar | 16670223PubMed |
[54] Millett GA, Flores SA, Peterson JL, Bakeman R. Explaining disparities in HIV infection among black and white men who have sex with men: a meta-analysis of HIV risk behaviors. AIDS 2007; 21 2083–91.
| Explaining disparities in HIV infection among black and white men who have sex with men: a meta-analysis of HIV risk behaviors.Crossref | GoogleScholarGoogle Scholar | 17885299PubMed |
[55] Matthews DD, Herrick AL, Coulter RW, Friedman MR, Mills TC, Eaton LA, et al Running backwards: consequences of current HIV incidence rates for the next generation of Black MSM in the United States. AIDS Behav 2016; 20 7–16.
| Running backwards: consequences of current HIV incidence rates for the next generation of Black MSM in the United States.Crossref | GoogleScholarGoogle Scholar | 26267251PubMed |
[56] Hess K, Hu X, Lansky A, Mermin J, Hall HI. Estimating the lifetime risk of a diagnosis of HIV infection in the United States. Conference on Retroviruses and Opportunistic Infections (CROI); 23 February 2016; Boston, MA, USA; 2016.
[57] Beyrer C. HIV epidemiology update and transmission factors: risks and risk contexts–16th International AIDS Conference epidemiology plenary. Nephrol Dial Transplant 2007; 44 981–7.
[58] Bourne A, Reid D, Hickson F, Rueda ST, Weatherburn P. The Chemsex Study: drug use in sexual settings among gay and bisexual men in Lambeth, Southwark & Lewisham 2014. Available online at: www.sigmaresearch.org.uk/chemsex [verified 2 June 2016].
[59] Wu Z, Xu J, Liu E, Mao Y, Xiao Y, Sun X, et al HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Nephrol Dial Transplant 2013; 57 298–309.
[60] Liau A, Millett G, Marks G. Meta-analytic examination of online sex-seeking and sexual risk behavior among men who have sex with men. Sex Transm Dis 2006; 33 576–84.
| Meta-analytic examination of online sex-seeking and sexual risk behavior among men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 16540884PubMed |
[61] Mayer KH, Bekker LG, Stall R, Grulich AE, Colfax G, Lama JR. Comprehensive clinical care for men who have sex with men: an integrated approach. Lancet 2012; 380 378–87.
| Comprehensive clinical care for men who have sex with men: an integrated approach.Crossref | GoogleScholarGoogle Scholar | 22819653PubMed |
[62] Mayer KH, Venkatesh KK. Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition. Am J Reprod Immunol 2011; 65 308–16.
| Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition.Crossref | GoogleScholarGoogle Scholar | 21214660PubMed |
[63] Kelley CF, Vaughan AS, Luisi N, Sanchez TH, Salazar LF, Frew PM, et al The effect of high rates of bacterial sexually transmitted infections on HIV incidence in a cohort of Black and White men who have sex with men in Atlanta, Georgia. AIDS Res Hum Retroviruses 2015; 31 587–92.
| The effect of high rates of bacterial sexually transmitted infections on HIV incidence in a cohort of Black and White men who have sex with men in Atlanta, Georgia.Crossref | GoogleScholarGoogle Scholar | 25719950PubMed |
[64] Smith AM, Grierson J, Wain D, Pitts M, Pattison P. Associations between the sexual behaviour of men who have sex with men and the structure and composition of their social networks. Sex Transm Infect 2004; 80 455–8.
| Associations between the sexual behaviour of men who have sex with men and the structure and composition of their social networks.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2crpvFGksw%3D%3D&md5=bf50fc97a2f23e4221dceb01d9bc65a3CAS | 15572613PubMed |
[65] Johnson WD, Diaz RM, Flanders WD, Goodman M, Hill AN, Holtgrave D, et al Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev 2008; CD001230
| Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 18646068PubMed |
[66] Kelly JA, Amirkhanian YA, McAuliffe TL, Granskaya JV, Borodkina OI, Dyatlov RV, et al HIV risk characteristics and prevention needs in a community sample of bisexual men in St. Petersburg, Russia. AIDS Care 2002; 14 63–76.
| HIV risk characteristics and prevention needs in a community sample of bisexual men in St. Petersburg, Russia.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD38%2Fnt1aksg%3D%3D&md5=9ce9dc4175e60183329bce6970f86e2fCAS | 11798406PubMed |
[67] Tieu HV, Li X, Donnell D, Vittinghoff E, Buchbinder S, Parente ZG, et al Anal sex role segregation and versatility among men who have sex with men: EXPLORE Study. J Acquir Immune Defic Syndr 2013; 64 121–5.
| Anal sex role segregation and versatility among men who have sex with men: EXPLORE Study.Crossref | GoogleScholarGoogle Scholar | 23945255PubMed |
[68] Mayer KH, Wheeler DP, Bekker LG, Grinsztejn B, Remien RH, Sandfort TG, et al Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men. J Acquir Immune Defic Syndr 2013; 63 S161–7.
| Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 23764630PubMed |
[69] Goodreau SM, Peinado J, Goicochea P, Vergara J, Ojeda N, Casapia M, et al Role versatility among men who have sex with men in urban Peru. J Sex Res 2007; 44 233–9.
| Role versatility among men who have sex with men in urban Peru.Crossref | GoogleScholarGoogle Scholar | 17879166PubMed |
[70] Hernández-Romieu AC, Sullivan PS, Rothenberg R, Grey J, Luisi N, Kelley CF, et al Heterogeneity of HIV prevalence among the sexual networks of Black and White men who have sex with men in Atlanta: illuminating a mechanism for increased HIV risk for young Black men who have sex with men. Sex Transm Dis 2015; 42 505–12.
| Heterogeneity of HIV prevalence among the sexual networks of Black and White men who have sex with men in Atlanta: illuminating a mechanism for increased HIV risk for young Black men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 26267877PubMed |
[71] Valleroy LA, MacKellar DA, Karon JM, Rosen DH, McFarland W, Shehan DA, et al HIV prevalence and associated risks in young men who have sex with men. Young Men’s Survey Study Group. JAMA 2000; 284 198–204.
| HIV prevalence and associated risks in young men who have sex with men. Young Men’s Survey Study Group.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3czkvFGkug%3D%3D&md5=c50968debc0e671a271334cbde5fb970CAS | 10889593PubMed |
[72] Centers for Disease Control and Prevention Prevalence and awareness of HIV infection among men who have sex with men—21 Cities, United States, 2008. MMWR Morb Mortal Wkly Rep 2010; 59 1201–7.
| 20864920PubMed |
[73] Blake SM, Ledsky R, Lehman T, Goodenow C, Sawyer R, Hack T. Preventing sexual risk behaviors among gay, lesbian, and bisexual adolescents: the benefits of gay-sensitive HIV instruction in schools. Am J Public Health 2001; 91 940–6.
| Preventing sexual risk behaviors among gay, lesbian, and bisexual adolescents: the benefits of gay-sensitive HIV instruction in schools.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3MzhvVyqsw%3D%3D&md5=1bbd1cf620c425dfb534011a7aeec279CAS | 11392938PubMed |
[74] Centers for Disease Control and Prevention. HIV and young men who have sex with men. July 2014. Available online at: http://www.cdc.gov/healthyyouth/sexualbehaviors/pdf/hiv_factsheet_ymsm.pdf [verified 2 June 2016].
[75] Mustanski B. Ethical and regulatory issues with conducting sexuality research with LGBT adolescents: a call to action for a scientifically informed approach. Arch Sex Behav 2011; 40 673–86.
| Ethical and regulatory issues with conducting sexuality research with LGBT adolescents: a call to action for a scientifically informed approach.Crossref | GoogleScholarGoogle Scholar | 21528402PubMed |
[76] Idele P, Gillespie A, Porth T, Suzuki C, Mahy M, Kasedde S, et al Epidemiology of HIV and AIDS among adolescents: current status, inequities, and data gaps. J Acquir Immune Defic Syndr 2014; 66 S144–53.
| Epidemiology of HIV and AIDS among adolescents: current status, inequities, and data gaps.Crossref | GoogleScholarGoogle Scholar | 24918590PubMed |
[77] Baral SD, Ketende S, Mnisi Z, Mabuza X, Grosso A, Sithole B, et al A cross-sectional assessment of the burden of HIV and associated individual- and structural-level characteristics among men who have sex with men in Swaziland. J Int AIDS Soc 2013; 16 18768
| A cross-sectional assessment of the burden of HIV and associated individual- and structural-level characteristics among men who have sex with men in Swaziland.Crossref | GoogleScholarGoogle Scholar | 24321117PubMed |
[78] Ayala G, Makofane K, Santos GM, Beck J, Do TD, Hebert P, et al Access to basic HIV-related services and PrEP acceptability among men who have sex with men worldwide: barriers, facilitators, and implications for combination prevention. J Sex Transm Dis 2013; 1–11
| Access to basic HIV-related services and PrEP acceptability among men who have sex with men worldwide: barriers, facilitators, and implications for combination prevention.Crossref | GoogleScholarGoogle Scholar |
[79] Schwartz SR, Nowak RG, Orazulike I, Keshinro B, Ake J, Kennedy S, et al The immediate effect of the Same-Sex Marriage Prohibition Act on stigma, discrimination, and engagement on HIV prevention and treatment services in men who have sex with men in Nigeria: analysis of prospective data from the TRUST cohort. Lancet HIV 2015; 2 e299–306.
| The immediate effect of the Same-Sex Marriage Prohibition Act on stigma, discrimination, and engagement on HIV prevention and treatment services in men who have sex with men in Nigeria: analysis of prospective data from the TRUST cohort.Crossref | GoogleScholarGoogle Scholar | 26125047PubMed |
[80] Risher K, Adams D, Sithole B, Ketende S, Kennedy C, Mnisi Z, et al Sexual stigma and discrimination as barriers to seeking appropriate healthcare among men who have sex with men in Swaziland. J Int AIDS Soc 2013; 16 18715
| 24242263PubMed |
[81] Pachankis JE, Hatzenbuehler ML, Hickson F, Weatherburn P, Berg RC, Marcus U, et al Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey. AIDS 2015; 29 1239–46.
| Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey.Crossref | GoogleScholarGoogle Scholar | 26035323PubMed |
[82] Oldenburg CE, Perez-Brumer AG, Hatzenbuehler ML, Krakower D, Novak DS, Mimiaga MJ, et al State-level structural sexual stigma and HIV prevention in a national online sample of HIV-uninfected MSM in the United States. AIDS 2015; 29 837–45.
| State-level structural sexual stigma and HIV prevention in a national online sample of HIV-uninfected MSM in the United States.Crossref | GoogleScholarGoogle Scholar | 25730508PubMed |
[83] Chakrapani V, Newman PA, Shunmugam M, Dubrow R. Barriers to free antiretroviral treatment access among kothi-identified men who have sex with men and aravanis (transgender women) in Chennai, India. AIDS Care 2011; 23 1687–94.
| Barriers to free antiretroviral treatment access among kothi-identified men who have sex with men and aravanis (transgender women) in Chennai, India.Crossref | GoogleScholarGoogle Scholar | 22117127PubMed |
[84] Adebajo SB, Eluwa GI, Allman D, Myers T, Ahonsi BA. Prevalence of internalized homophobia and HIV associated risks among men who have sex with men in Nigeria. Afr J Reprod Health 2012; 16 21–8.
| 23444540PubMed |
[85] Burnham KE, Cruess DG, Kalichman MO, Grebler T, Cherry C, Kalichman SC. Trauma symptoms, internalized stigma, social support, and sexual risk behavior among HIV-positive gay and bisexual MSM who have sought sex partners online. AIDS Care 2016; 28 347–53.
| Trauma symptoms, internalized stigma, social support, and sexual risk behavior among HIV-positive gay and bisexual MSM who have sought sex partners online.Crossref | GoogleScholarGoogle Scholar | 26461452PubMed |
[86] Gamarel KE, Neilands TB, Dilworth SE, Taylor JM, Johnson MO. Smoking, internalized heterosexism, and HIV disease management among male couples. AIDS Care 2015; 27 649–54.
| Smoking, internalized heterosexism, and HIV disease management among male couples.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2Mznslegug%3D%3D&md5=03f130c0204227e5e4ee711cf0afd0d6CAS | 25506724PubMed |
[87] Pyun T, Santos GM, Arreola S, Do T, Hebert P, Beck J, et al Internalized homophobia and reduced HIV testing among men who have sex with men in China. Asia Pac J Public Health 2014; 26 118–25.
| Internalized homophobia and reduced HIV testing among men who have sex with men in China.Crossref | GoogleScholarGoogle Scholar | 24554493PubMed |
[88] Ross MW, Kajubi P, Mandel JS, McFarland W, Raymond HF. Internalized homonegativity/homophobia is associated with HIV-risk behaviours among Ugandan gay and bisexual men. Int J STD AIDS 2013; 24 409–13.
| Internalized homonegativity/homophobia is associated with HIV-risk behaviours among Ugandan gay and bisexual men.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3sbit1SqsQ%3D%3D&md5=e38498871326ce3ff2771192c85c1a68CAS | 23970711PubMed |
[89] Berg RC, Ross MW, Weatherburn P, Schmidt AJ. Structural and environmental factors are associated with internalised homonegativity in men who have sex with men: findings from the European MSM Internet Survey (EMIS) in 38 countries. Soc Sci Med 2013; 78 61–9.
| Structural and environmental factors are associated with internalised homonegativity in men who have sex with men: findings from the European MSM Internet Survey (EMIS) in 38 countries.Crossref | GoogleScholarGoogle Scholar | 23261257PubMed |
[90] Fay H, Baral SD, Trapence G, Motimedi F, Umar E, Iipinge S, et al Stigma, health care access, and HIV knowledge among men who have sex with men in Malawi, Namibia, and Botswana. AIDS Behav 2011; 15 1088–97.
| Stigma, health care access, and HIV knowledge among men who have sex with men in Malawi, Namibia, and Botswana.Crossref | GoogleScholarGoogle Scholar | 21153432PubMed |
[91] Mason K, Ketende S, Peitzmeier S, Ceesay N, Logie C, Diouf D, et al Stigma, human rights violations, health care access, and disclosure among men who have sex with men in the Gambia. J Human Rights Prac 2015; 7 139–52.
| Stigma, human rights violations, health care access, and disclosure among men who have sex with men in the Gambia.Crossref | GoogleScholarGoogle Scholar |
[92] Stahlman S, Grosso A, Ketende S, Sweitzer S, Mothopeng T, Taruberekera N, et al Depression and social stigma among MSM in Lesotho: implications for HIV and sexually transmitted infection prevention. AIDS Behav 2015; 19 1460–9.
| Depression and social stigma among MSM in Lesotho: implications for HIV and sexually transmitted infection prevention.Crossref | GoogleScholarGoogle Scholar | 25969182PubMed |
[93] Zahn R, Grosso A, Scheibe A, Bekker LG, Ketende S, Dausab F, et al Human rights violations among men who have sex with men in Southern Africa: comparisons between legal contexts. PLoS One 2016; 11 e0147156
| Human rights violations among men who have sex with men in Southern Africa: comparisons between legal contexts.Crossref | GoogleScholarGoogle Scholar | 26764467PubMed |
[94] Alvy LM, McKirnan DJ, Mansergh G, Koblin B, Colfax GN, Flores SA, et al Depression is associated with sexual risk among men who have sex with men, but is mediated by cognitive escape and self-efficacy. AIDS Behav 2011; 15 1171–9.
| Depression is associated with sexual risk among men who have sex with men, but is mediated by cognitive escape and self-efficacy.Crossref | GoogleScholarGoogle Scholar | 20217471PubMed |
[95] O’Cleirigh C, Newcomb ME, Mayer KH, Skeer M, Traeger L, Safren SA. Moderate levels of depression predict sexual transmission risk in HIV-infected MSM: a longitudinal analysis of data from six sites involved in a “prevention for positives” study. AIDS Behav 2013; 17 1764–9.
| Moderate levels of depression predict sexual transmission risk in HIV-infected MSM: a longitudinal analysis of data from six sites involved in a “prevention for positives” study.Crossref | GoogleScholarGoogle Scholar | 23605154PubMed |
[96] Wei C, Cheung DH, Yan H, Li J, Shi LE, Raymond HF. The impact of homophobia and HIV stigma on HIV testing uptake among Chinese men who have sex with men: a mediation analysis. J Acquir Immune Defic Syndr 2016; 71 87–93.
| 26334742PubMed |
[97] Supervie V, Ndawinz JDA, Lodi S, Costagliola D. The undiagnosed HIV epidemic in France and its implications for HIV screening strategies. AIDS 2014; 28 1797–804.
| The undiagnosed HIV epidemic in France and its implications for HIV screening strategies.Crossref | GoogleScholarGoogle Scholar | 24681416PubMed |
[98] Mannheimer SB, Wang L, Wilton L, Van Tieu H, Del Rio C, Buchbinder S, et al Infrequent HIV testing and late HIV diagnosis are common among a cohort of black men who have sex with men in 6 US cities. J Acquir Immune Defic Syndr 2014; 67 438–45.
| Infrequent HIV testing and late HIV diagnosis are common among a cohort of black men who have sex with men in 6 US cities.Crossref | GoogleScholarGoogle Scholar | 25197830PubMed |
[99] Nelson KM, Thiede H, Jenkins RA, Carey JW, Hutcheson R, Golden MR. Personal and contextual factors related to delayed HIV diagnosis among men who have sex with men. AIDS Educ Prev 2014; 26 122–33.
| Personal and contextual factors related to delayed HIV diagnosis among men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 24694326PubMed |
[100] Dowson L, Kober C, Perry N, Fisher M, Richardson D. Why some MSM present late for HIV testing: a qualitative analysis. AIDS Care 2012; 24 204–9.
| 21780956PubMed |
[101] Commission on AIDS in Asia. Redefining AIDS in Asia: crafting an effective response. New Delhi: Oxford University Press; 2008.
[102] Golden MR, Bennett AB, Dombrowski JC, Buskin SE. Achieving the goals of the National HIV/AIDS strategy: declining HIV diagnoses, improving clinical outcomes, and diminishing racial/ethnic disparities in King County, WA (2004–2013). Sex Transm Dis 2016; 43 269–76.
| Achieving the goals of the National HIV/AIDS strategy: declining HIV diagnoses, improving clinical outcomes, and diminishing racial/ethnic disparities in King County, WA (2004–2013).Crossref | GoogleScholarGoogle Scholar | 27100761PubMed |
[103] Pettifor A, Nguyen NL, Celum C, Cowan FM, Go V, Hightow-Weidman L. Tailored combination prevention packages and PrEP for young key populations. J Int AIDS Soc 2015; 18 19434
| 25724507PubMed |
[104] Coates TJ, Richter L, Caceres C. Behavioural strategies to reduce HIV transmission: how to make them work better. Lancet 2008; 372 669–84.
| Behavioural strategies to reduce HIV transmission: how to make them work better.Crossref | GoogleScholarGoogle Scholar | 18687459PubMed |
[105] Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363 2587–99.
| Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXit1ansg%3D%3D&md5=6e22600cda8924441c0d2faa55711ff6CAS | 21091279PubMed |
[106] Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al On-demand preexposure prophylaxis in men at high risk for HIV-1 infection. N Engl J Med 2015; 373 2237–46.
| On-demand preexposure prophylaxis in men at high risk for HIV-1 infection.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC28XntFSnsLc%3D&md5=af2ecb0d01037a9c93f407579f51b170CAS | 26624850PubMed |
[107] McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet 2016; 387 53–60.
| Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.Crossref | GoogleScholarGoogle Scholar | 26364263PubMed |
[108] Taddeo D, Egedy M, Frappier JY. Adherence to treatment in adolescents. Paediatr Child Health 2008; 13 19–24.
| 19119348PubMed |
[109] Salema NE, Elliott RA, Glazebrook C. A systematic review of adherence-enhancing interventions in adolescents taking long-term medicines. J Adolescent Health 2011; 49 455–66.
| A systematic review of adherence-enhancing interventions in adolescents taking long-term medicines.Crossref | GoogleScholarGoogle Scholar |
[110] Marcus JL, Buisker T, Horvath T, Amico KR, Fuchs JD, Buchbinder SP, et al Helping our patients take HIV pre-exposure prophylaxis (PrEP): a systematic review of adherence interventions. HIV Med 2014; 15 385–95.
| Helping our patients take HIV pre-exposure prophylaxis (PrEP): a systematic review of adherence interventions.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtFajtr%2FJ&md5=e1be3572001e61637eb7e1476d8d6c13CAS | 24580813PubMed |
[111] Hosek SG, Siberry G, Bell M, Lally M, Kapogiannis B, Green K, et al The acceptability and feasibility of an HIV preexposure prophylaxis (PrEP) trial with young men who have sex with men. J Acquir Immune Defic Syndr 2013; 62 447–56.
| The acceptability and feasibility of an HIV preexposure prophylaxis (PrEP) trial with young men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 24135734PubMed |
[112] Spinner CD, Boesecke C, Zink A, Jessen H, Stellbrink HJ, Rockstroh JK, et al HIV pre-exposure prophylaxis (PrEP): a review of current knowledge of oral systemic HIV PrEP in humans. Infection 2016; 44 151–8.
| HIV pre-exposure prophylaxis (PrEP): a review of current knowledge of oral systemic HIV PrEP in humans.Crossref | GoogleScholarGoogle Scholar | 26471511PubMed |
[113] Global Advocacy for HIV Prevention (AVAC). PrEPWatch: country updates. Available online at: http://www.prepwatch.org/advocacy/country-updates/ [verified 4 January 2016].
[114] Authors. NHS England confirms decision not to fund drug that helps prevent HIV. 2016. Available online at: http://home.bt.com/news/uk-news/nhs-england-confirms-decision-not-to-fund-drug-that-helps-prevent-hiv-11364065437179 [verified 2 June 2016].
[115] Boily MC, Shubber Z. Modelling in concentrated epidemics: informing epidemic trajectories and assessing prevention approaches. Curr Opin HIV AIDS 2014; 9 134–49.
| Modelling in concentrated epidemics: informing epidemic trajectories and assessing prevention approaches.Crossref | GoogleScholarGoogle Scholar | 24468893PubMed |
[116] Baral S, Scheibe A, Sullivan P, Trapence G, Lambert A, Bekker LG, et al Assessing priorities for combination HIV prevention research for men who have sex with men (MSM) in Africa. AIDS Behav 2013; 17 S60–9.
| Assessing priorities for combination HIV prevention research for men who have sex with men (MSM) in Africa.Crossref | GoogleScholarGoogle Scholar | 22610371PubMed |
[117] Mugo NR, Ngure K, Kiragu M, Irungu E, Kilonzo N. The preexposure prophylaxis revolution; from clinical trials to programmatic implementation. Curr Opin HIV AIDS 2016; 11 80–6.
| The preexposure prophylaxis revolution; from clinical trials to programmatic implementation.Crossref | GoogleScholarGoogle Scholar | 26575147PubMed |
[118] Firestone R, Rivas J, Lungo S, Cabrera A, Ruether S, Wheeler J, et al Effectiveness of a combination prevention strategy for HIV risk reduction with men who have sex with men in Central America: a mid-term evaluation. BMC Public Health 2014; 14 1244
| Effectiveness of a combination prevention strategy for HIV risk reduction with men who have sex with men in Central America: a mid-term evaluation.Crossref | GoogleScholarGoogle Scholar | 25471459PubMed |
[119] Gomez GB, Borquez A, Caceres CF, Segura ER, Grant RM, Garnett GP, et al The potential impact of pre-exposure prophylaxis for HIV prevention among men who have sex with men and transwomen in Lima, Peru: a mathematical modelling study. PLoS Med 2012; 9 e1001323
| The potential impact of pre-exposure prophylaxis for HIV prevention among men who have sex with men and transwomen in Lima, Peru: a mathematical modelling study.Crossref | GoogleScholarGoogle Scholar | 23055836PubMed |
[120] Sood N, Wagner Z, Jaycocks A, Drabo E, Vardavas R. Test-and-treat in Los Angeles: a mathematical model of the effects of test-and-treat for the population of men who have sex with men in Los Angeles County. Nephrol Dial Transplant 2013; 56 1789–96.
[121] Jones A, Cremin I, Abdullah F, Idoko J, Cherutich P, Kilonzo N, et al Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention. Lancet 2014; 384 272–9.
| Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention.Crossref | GoogleScholarGoogle Scholar | 24740087PubMed |
[122] Makofane K, Beck J, Ayala G. MSM in Sub-Saharan Africa: health, access, and HIV. Findings from the Global Men’s Health and Rights Study; 2012. Available online at: msmgf.org/files/msmgf/documents/MSMinSSA_PolicyBrief.pdf [verified 2 June 2016].
[123] Public Health England UK standards for microbiology investigations: anti-HIV screening. Virology 2014; 11 1–11.
[124] Joint United Nations Programme on HIV/AIDS (UNAIDS). A short technical update on self-testing for HIV; 2014. Available online at: http://www.unaids.org/sites/default/files/media_asset/JC2603_self-testing_en_0.pdf [verified 10 February 2016].
[125] United Nations International Children’s Emergency Fund (UNICEF). Adolescents under the radar in the Asia-Pacific AIDS response. Bangkok, Thailand; 2015. Available online at: http://www.unicef.org/eapro/Adolescents_Under_the_Radar_final.pdf. [verified 5 July 2016].
[126] Withey J. Sharp rise in HIV infections among young gay men in China; 2015. Available online at: https://www.gaytimes.co.uk/news/18829/sharp-rise-in-hiv-infections-among-young-gay-men-in-china/ [verified 19 January 2016].
[127] Muessig KE, Nekkanti M, Bauermeister J, Bull S, Hightow-Weidman LB. A systematic review of recent smartphone, Internet and Web 2.0 interventions to address the HIV continuum of care. Curr HIV/AIDS Rep 2015; 12 173–90.
| A systematic review of recent smartphone, Internet and Web 2.0 interventions to address the HIV continuum of care.Crossref | GoogleScholarGoogle Scholar | 25626718PubMed |
[128] Sullivan PS, Grey JA, Simon Rosser BR. Emerging technologies for HIV prevention for MSM: what we have learned, and ways forward. J Acquir Immune Defic Syndr 2013; 63 S102–7.
| Emerging technologies for HIV prevention for MSM: what we have learned, and ways forward.Crossref | GoogleScholarGoogle Scholar | 23673879PubMed |
[129] McGowan I, Cranston RD, Duffill K, Siegel A, Engstrom JC, Nikiforov A, et al A phase 1 randomized, open label, rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of three formulations of Tenofovir 1% Gel (the CHARM-01 Study). PLoS One 2015; 10 e0125363
| A phase 1 randomized, open label, rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of three formulations of Tenofovir 1% Gel (the CHARM-01 Study).Crossref | GoogleScholarGoogle Scholar | 25942472PubMed |
[130] McGowan I. The development of rectal microbicides for HIV prevention. Expert Opin Drug Deliv 2014; 11 69–82.
| The development of rectal microbicides for HIV prevention.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhvFOnu7zI&md5=761810906ad477d6cfff1a8e49667cb6CAS | 24266648PubMed |
[131] Wang HB, Mo QH, Yang Z. HIV vaccine research: the challenge and the way forward. J Immunol Res 2015; 2015 503978
| HIV vaccine research: the challenge and the way forward.Crossref | GoogleScholarGoogle Scholar | 25861656PubMed |
[132] Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, et al Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 2015; 522 487–91.
| Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXmt1Smtrw%3D&md5=843d1b09dbbba487667ce7732dd0f3a3CAS | 25855300PubMed |
[133] Kong R, Louder MK, Wagh K, Bailer RT, deCamp A, Greene K, et al Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes. J Virol 2015; 89 2659–71.
| Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes.Crossref | GoogleScholarGoogle Scholar | 25520506PubMed |
[134] Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME, et al Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol 2015; 182 289–301.
| Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhvVSlsL%2FE&md5=c888b2dfa65a9f7296c28f09a3121cb7CAS | 26332605PubMed |
[135] Baral S, Logie CH, Grosso A, Wirtz AL, Beyrer C. Modified social ecological model: a tool to guide the assessment of the risks and risk contexts of HIV epidemics. BMC Public Health 2013; 13 482
| Modified social ecological model: a tool to guide the assessment of the risks and risk contexts of HIV epidemics.Crossref | GoogleScholarGoogle Scholar | 23679953PubMed |
[136] Pando MA, Gómez-Carrillo M, Vignoles M, Rubio AE, dos Ramos Farias MS, Vila M, et al. Incidence of HIV type 1 infection, antiretroviral drug resistance, and molecular characterization in newly diagnosed individuals in Argentina: a global fund project. AIDS Res Hum Retroviruses. 2011; 27:17–23.
[137] The Kirby Institute for Infection and Immunity in Society. Figure 46. HIV incidence rate per 100 person years in gay and bisexual men and female sex workers attending sexual health clinics, 2011–2014. Available online at: https://kirby.unsw.edu.au/content/2015-asr-figures-data [verified 13 April 2016].
[138] Silva AP, Greco M, Fausto MA, Greco DB, Carneiro M. Risk factors associated with HIV infection among male homosexuals and bisexuals followed in an open cohort study: Project Horizonte, Brazil (1994–2010). PLoS One 2014; 9 e109390
| Risk factors associated with HIV infection among male homosexuals and bisexuals followed in an open cohort study: Project Horizonte, Brazil (1994–2010).Crossref | GoogleScholarGoogle Scholar | 25279670PubMed |
[139] Li SW, Zhang XY, Li XX, Wang MJ, Li DL, Ruan YH, et al Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005–2006. Chin Med J (Engl) 2008; 121 1105–8.
| 18706227PubMed |
[140] Han M, Feng LG, Jiang Y, Shen S, Ling H, Ding XB, et al Surveillance on HIV-1 incidence among men who have sex with men in Chongqing, China, 2006–2008. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2009; 30 878–81.
| 20193218PubMed |
[141] Xu J, An M, Han X, Jia M, Ma Y, Zhang M, et al Prospective cohort study of HIV incidence and molecular characteristics of HIV among men who have sex with men (MSM) in Yunnan Province, China. BMC Infect Dis 2013; 13 3
| Prospective cohort study of HIV incidence and molecular characteristics of HIV among men who have sex with men (MSM) in Yunnan Province, China.Crossref | GoogleScholarGoogle Scholar | 23286213PubMed |
[142] Wang Q-Q, Chen X-S, Yin Y-P, Liang G-J, Zhang R-L, Jiang N, et al HIV prevalence, incidence and risk behaviours among men who have sex with men in Yangzhou and Guangzhou, China: a cohort study. J Int AIDS Soc 2014; 17 18849
| HIV prevalence, incidence and risk behaviours among men who have sex with men in Yangzhou and Guangzhou, China: a cohort study.Crossref | GoogleScholarGoogle Scholar | 25103308PubMed |
[143] Mao H, Ma W, Lu H, Wang L, Zheng H, Zhu Y, et al High incidence of HIV and syphilis among migrant men who have sex with men in Beijing, China: a prospective cohort study. BMJ Open 2014; 4 e005351
| High incidence of HIV and syphilis among migrant men who have sex with men in Beijing, China: a prospective cohort study.Crossref | GoogleScholarGoogle Scholar | 25227626PubMed |
[144] Wang Y, Huang Y, Chen H, Li L, Xu J, Li Z, et al Incidence and correlates of HIV and syphilis in a prospective cohort of men who have sex with men in Mianyang, China, over a 36-month period. Sex Health 2015; 12 546–555.
| Incidence and correlates of HIV and syphilis in a prospective cohort of men who have sex with men in Mianyang, China, over a 36-month period.Crossref | GoogleScholarGoogle Scholar | 26318795PubMed |
[145] Liu G, Lu H, Wang J, Xia D, Sun Y, Mi G, et al Incidence of HIV and syphilis among men who have sex with men (MSM) in Beijing: an open cohort study. PLoS One 2015; 10 e0138232
| Incidence of HIV and syphilis among men who have sex with men (MSM) in Beijing: an open cohort study.Crossref | GoogleScholarGoogle Scholar | 26426271PubMed |
[146] Li D, Yang X, Zhang Z, Wang Z, Qi X, Ruan Y, et al Incidence of co-infections of HIV, herpes simplex virus type 2 and syphilis in a large cohort of men who have sex with men in Beijing, China. PLoS One 2016; 11 e0147422
| Incidence of co-infections of HIV, herpes simplex virus type 2 and syphilis in a large cohort of men who have sex with men in Beijing, China.Crossref | GoogleScholarGoogle Scholar | 26820145PubMed |
[147] Hui S, Li Y, Yan H, Guo W, Tong X, Wang K. HIV incidence and factor related to lost-to-follow-up among men who have sex with men in Harbin, Heilongjiang. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2015; 36 1381–3.
| 26850394PubMed |
[148] Soto RJ, Ghee AE, Nunez CA, Mayorga R, Tapia KA, Astete SG, et al Sentinel surveillance of sexually transmitted infections/HIV and risk behaviors in vulnerable populations in 5 Central American countries. J Acquir Immune Defic Syndr 2007; 46 101–11.
| 17972366PubMed |
[149] Le Vu S, Velter A, Meyer L, Peytavin G, Guinard J, Pillonel J, et al Biomarker-based HIV incidence in a community sample of men who have sex with men in Paris, France. PLoS One 2012; 7 e39872
| Biomarker-based HIV incidence in a community sample of men who have sex with men in Paris, France.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XpvVCgu7w%3D&md5=fc6004687ed5d08c2aac7d85d7a2cb45CAS | 22768150PubMed |
[150] Ghosh S, Mahapatra BB, Bania D. HIV incidence among men who sex with men: evidence from north-eastern part of India. 20th International AIDS Conference; Melbourne, Australia; 2014; Available online at: http://pag.aids2014.org/Abstracts.aspx?AID=6689 [verified 5 July 2016].
[151] Giuliani M, Vescio MF, Latini A, Palamara G, Pimpinelli F, Dona MG, et al Continuous increase in HIV-1 incidence after the year 2000 among men who have sex with men in Rome: insights from a 25-year retrospective cohort study. Euro Commun Dis Bull 2014; 19 20969
| Continuous increase in HIV-1 incidence after the year 2000 among men who have sex with men in Rome: insights from a 25-year retrospective cohort study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2MzktVagsg%3D%3D&md5=1bf50581b741d8693e66b06322aeb520CAS |
[152] Wahome E, Fegan G, Okuku HS, Mugo P, Price MA, Mwashigadi G, et al Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya. AIDS 2013; 27 2163–6.
| Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya.Crossref | GoogleScholarGoogle Scholar | 23842136PubMed |
[153] Sanders EJ, Okuku HS, Smith AD, Mwangome M, Wahome E, Fegan G, et al High HIV-1 incidence, correlates of HIV-1 acquisition, and high viral loads following seroconversion among MSM. AIDS 2013; 27 437–46.
| High HIV-1 incidence, correlates of HIV-1 acquisition, and high viral loads following seroconversion among MSM.Crossref | GoogleScholarGoogle Scholar | 23079811PubMed |
[154] Jansen IA, Geskus RB, Davidovich U, Jurriaans S, Coutinho RA, Prins M, et al Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study. AIDS 2011; 25 493–501.
| Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study.Crossref | GoogleScholarGoogle Scholar | 21192230PubMed |
[155] Meireles P, Lucas R, Carvalho C, Fuertes R, Brito J, Campos MJ, et al Incident risk factors as predictors of HIV seroconversion in the Lisbon cohort of men who have sex with men: first results, 2011–2014. Euro Commun Dis Bull 2015; 20 1–12.
[156] Dramé FM, Crawford EE, Diouf D, Beyrer C, Baral SD. A pilot cohort study to assess the feasibility of HIV prevention science research among men who have sex with men in Dakar, Senegal. J Int AIDS Soc 2013; 16 18753
| 24321115PubMed |
[157] Ferrer L , Loureiro E, Meulbroek M, Folch C, Perez F, Esteve A, et al High HIV incidence among men who have sex with men attending a community-based voluntary counselling and testing service in Barcelona, Spain: results from the ITACA cohort. Sex Transm Infect 2016; 92 70–5.
| High HIV incidence among men who have sex with men attending a community-based voluntary counselling and testing service in Barcelona, Spain: results from the ITACA cohort.Crossref | GoogleScholarGoogle Scholar | 26136507PubMed |
[158] Centers for Disease Control and Prevention. HIV and syphilis infection among men who have sex with men–Bangkok, Thailand, 2005–2011. MMWR Morb Mortal Wkly Rep 2013; 62 518–20.
| 23803960PubMed |
[159] Brown EL, Wald A, Hughes JP, Morrow RA, Krantz E, Mayer K, et al High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study. Am J Epidemiol 2006; 164 733–41.
| High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD28rotVWqsw%3D%3D&md5=a2ca793bb9724a2200dab8a7805cec92CAS | 16896053PubMed |
[160] Balaji AB, Bowles KE, Le BC, Paz-Bailey G, Oster AM. High HIV incidence and prevalence and associated factors among young MSM, 2008. AIDS 2013; 27 269–78.
| High HIV incidence and prevalence and associated factors among young MSM, 2008.Crossref | GoogleScholarGoogle Scholar | 23079807PubMed |
[161] Koblin BA, Mayer KH, Eshleman SH, Wang L, Mannheimer S, del Rio C, et al Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061. PLoS One 2013; 8 e70413
| Correlates of HIV acquisition in a cohort of Black men who have sex with men in the United States: HIV prevention trials network (HPTN) 061.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXht1Gitr7N&md5=19e05a06d4ebe81f920ce0116abfb3feCAS | 23922989PubMed |
[162] Pathela P, Braunstein SL, Blank S, Schillinger JA. HIV incidence among men with and those without sexually transmitted rectal infections: estimates from matching against an HIV case registry. Nephrol Dial Transplant 2013; 57 1203–9.
[163] Halkitis P, Kapadia F, Ompad D. Incidence of HIV infection in young gay, bisexual, and other YMSM: the P18 Cohort Study. J Acquir Immune Defic Syndr 2015; 69 466–73.
| Incidence of HIV infection in young gay, bisexual, and other YMSM: the P18 Cohort Study.Crossref | GoogleScholarGoogle Scholar | 26115438PubMed |
[164] Raymond HF, Chen YH, McFarland W. Estimating incidence of HIV infection among men who have sex with men, San Francisco, 2004–2014. AIDS Behav 2016; 20 17–21.
| Estimating incidence of HIV infection among men who have sex with men, San Francisco, 2004–2014.Crossref | GoogleScholarGoogle Scholar | 26471885PubMed |
[165] Jain S, Oldenburg CE, Mimiaga MJ, Mayer KH. Subsequent HIV infection among men who have sex with men who used non-occupational post-exposure prophylaxis at a Boston community health center: 1997–2013. AIDS Patient Care STDS 2015; 29 20–5.
| Subsequent HIV infection among men who have sex with men who used non-occupational post-exposure prophylaxis at a Boston community health center: 1997–2013.Crossref | GoogleScholarGoogle Scholar | 25369451PubMed |
[166] Katz DA, Dombrowski JC, Bell TR, Kerani RP, Golden MR. HIV incidence among men who have sex with men after diagnosis with sexually transmitted infections. Sex Transm Dis 2016; 43 249–54.
| HIV incidence among men who have sex with men after diagnosis with sexually transmitted infections.Crossref | GoogleScholarGoogle Scholar | 26967302PubMed |