Livestock pluripotency is finally captured in vitro
Micaela Navarro A , Delia A. Soto A , Carlos A. Pinzon B , Jun Wu B C and Pablo J. Ross A DA Department of Animal Science, University of California, 450 Bioletti Way, Davis, CA 95616, USA.
B Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
C Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
D Corresponding author. Email: pross@ucdavis.edu
Reproduction, Fertility and Development 32(2) 11-39 https://doi.org/10.1071/RD19272
Published: 2 December 2019
Abstract
Pluripotent stem cells (PSCs) have demonstrated great utility in improving our understanding of mammalian development and continue to revolutionise regenerative medicine. Thanks to the improved understanding of pluripotency in mice and humans, it has recently become feasible to generate stable livestock PSCs. Although it is unlikely that livestock PSCs will be used for similar applications as their murine and human counterparts, new exciting applications that could greatly advance animal agriculture are being developed, including the use of PSCs for complex genome editing, cellular agriculture, gamete generation and in vitro breeding schemes.
Additional keywords: cattle, embryo, embryonic stem cells, induced pluripotent stem cells, inhibitor of Wnt response (IWR)-1, pig, tankyrase, Wingless/Integrated (WNT) signaling pathway.
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