Role of maternal interleukin-8 (IL-8) in normal-term birth in the human
Vahid Ehsani A , Maryam Mortazavi
A B J , Khodayar Ghorban C , Maryam Dadmanesh D , Reza Bahramabadi A I , Mohammad-Taghi Rezayati A , Esmat Javadi-Moghadam B , Zahra Rezaei B , Zahra Sabzali B , Iman Fatemi E F , Mahmood Sheikh Fathollahi A G and Mohammad Kazemi Arababadi A H
+ Author Affiliations
- Author Affiliations
A Immunology of Infectious Diseases Research Centre, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
B Department of Gynaecology and Obstetrics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
C Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran.
D Department of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran.
E Physiology–Pharmacology Research Centre, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
F Department of Physiology and Pharmacology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
G Department of Biostatistics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
H Department of Laboratory Medicine, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran.
I Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, 7616913555, Iran.
J Corresponding author. Email: m.mortazavi4742@rums.ac.ir
Reproduction, Fertility and Development 31(6) 1049-1056 https://doi.org/10.1071/RD18361
Submitted: 29 September 2018 Accepted: 7 January 2019 Published: 29 March 2019
Abstract
Cytokines are the main factors involved in the normal functions of the placenta and delivery process. The aim of this project was to compare serum levels of interleukin-8 (IL-8), IL-6, tumour necrosis factor α (TNF-α) and transforming growth factor β (TGF-β) in term and prolonged-pregnancy mothers and their neonates. This study was performed on 240 participants including 60 term and prolonged-pregnancy neonates and their corresponding mothers. Serum levels of IL-8, IL-6, TNF-α and TGF-β were evaluated by the enzyme-linked immunosorbent assay technique. The results revealed that IL-8 serum levels were significantly lower in the prolonged-pregnancy mothers and their neonates when compared with term mothers and their neonates. Data analysis also revealed a negative correlation between TGF-β and age of prolonged-pregnancy mothers. A poor positive correlation between IL-6 and head circumference of term neonates was also observed. IL-8 may play crucial roles in the process of on-time delivery and age may significantly affect TGF-β production in prolonged-pregnancy mothers. Pro-inflammatory cytokines, such as IL-6, can also be considered as main factors involved in fetal growth.
Additional keywords : cytokine, pregnancy, prolonged pregnancy.
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