Effects of long-term dietary supplementation with conjugated linoleic acid on bovine oocyte lipid profile
Andrés F. González-Serrano A , Christina R. Ferreira B , Valentina Pirro C , Andrea Lucas-Hahn A , Julia Heinzmann A , Klaus-Gerd Hadeler A , Ulrich Baulain A , Patrick Aldag A , Ulrich Meyer D , Marion Piechotta E , Gerhard Jahreis F , Sven Dänicke D , R. Graham Cooks B G and Heiner Niemann A G
+ Author Affiliations
- Author Affiliations
A Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Hoelty Strasse 10, 31535 Neustadt, Germany.
B Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, 207 South Martin Jischke Drive, West Lafayette, 47907 IN, USA.
C Department of Chemistry, University of Turin, Via Pietro Giuria 7, 10125 Turin, Italy.
D Institute of Animal Nutrition, Friedrich-Loeffler-Institut (FLI), Bundesallee 50, 38116 Braunschweig, Germany.
E Clinic for Cattle, University of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany.
F Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 25, 07743 Jena, Germany.
G Corresponding authors. Emails: heiner.niemann@fli.bund.de; cooks@purdue.edu
Reproduction, Fertility and Development 28(9) 1326-1339 https://doi.org/10.1071/RD14352
Submitted: 6 October 2014 Accepted: 13 January 2015 Published: 27 February 2015
Abstract
Nutritional and environmental conditions around conception and during early embryonic development may have significant effects on health and well-being in adult life. Here, a bovine heifer model was used to investigate the effects of rumen-protected fat supplementation on oocyte quality and embryo development. Holstein–Friesian heifers (n = 84) received a dietary supplement consisting of rumen-protected conjugated linoleic acid (CLA) or stearic acid (SA), each on top of an isocaloric basic diet. Oocytes were collected via ultrasound-guided follicular aspiration and subjected to in vitro maturation followed by either desorption electrospray ionisation mass spectrometry (DESI-MS) for lipid profiling of individual oocytes or in vitro fertilisation and embryo culture. The type of supplement significantly affected lipid profiles of in vitro-matured oocytes. Palmitic acid and plasmalogen species were more abundant in the mass spectra of in vitro-matured oocytes after rumen-protected SA supplementation when compared with those collected from animals supplemented with CLA. Lipid concentrations in blood and follicular fluid were significantly affected by both supplements. Results show that rumen-protected fatty-acid supplementation affects oocyte lipid content and may pave the way for the establishment of a large-animal model for studies towards a better understanding of reproductive disorders associated with nutritional impairments.
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