Melatonin administration during the first half of pregnancy improves physiological response and reproductive performance of rabbits under heat stress conditions
Nesrein M. Hashem
A B * , Elshymaa A. Abdelnaby C D , Mahmoud Madkour E and Hossam R. El-Sherbiny D
A
B
C
D
E
Handling Editor: Jose Alfonso Abecia
Abstract
Melatonin may have a heat-stress-alleviating role during pregnancy.
To investigate the effects of melatonin administration during the first half of pregnancy on heat-tolerance capacity and pregnancy outputs of naturally heat-stressed rabbits.
Forty female rabbits were stratified equally into two experimental groups and daily received 1 mg melatonin/kg body weight or not (control) for 15 consecutive days post-insemination. Heat tolerance indices, hormone profile, ovarian structures, and fetal loss were determined.
Treatment with melatonin significantly decreased respiration rate and rectal temperature, improved concentrations of nitric oxide, and tended to decrease malondialdehyde concentrations (P = 0.064) compared to control. Melatonin treatment significantly increased concentrations of high-density lipoprotein, oestradiol, and progesterone compared to control. No significant differences in the numbers of visible ovarian follicles, corpora lutea, and total implantation sites on day 18 of pregnancy were observed between experimental groups. However, melatonin treatment significantly reduced the number of absorbed implantation sites and significantly improved amniotic fluid volume and conception rate compared to control.
Melatonin administration during the first half of pregnancy can improve reproductive performance of heat-stressed female rabbits.
Melatonin can improve fetal survivability via improving heat-tolerance capacity of does and steroidogenesis.
Keywords: embryonic/fetal loss, melatonin, placenta, rabbit, reproduction, thermal stress, steroidogenesis.
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