Anti-tuberculosis drugs used in a directly observed treatment short course (DOTS) schedule alter endocrine patterns and reduce the ovarian reserve and oocyte quality in the mouse
Arpitha Rao A , Guruprasad Nayak A , Hanumappa Ananda A , Sandhya Kumari A , Rahul Dutta A , Sneha Guruprasad Kalthur B , Srinivas Mutalik C , Sneha Ann Thomas D , Renu Pasricha D , Shamprasad Varija Raghu E , Satish Kumar Adiga
F and Guruprasad Kalthur A *
+ Author Affiliations
- Author Affiliations
A Division of Reproductive Biology, Department of Reproductive Sciences, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
B Department of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
C Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
D Research Instrument Scientist 1-Electron Microscopy, Core Technology Platforms Operations, NYU, Abu Dhabi, United Arab Emirates.
E Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri 574199, Karnataka, India.
F Division of Clinical Embryology, Department of Reproductive Sciences, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Reproduction, Fertility and Development 34(17) 1059-1077 https://doi.org/10.1071/RD22108
Published online: 12 October 2022
© 2022 The Author(s) (or their employer(s)). Published by CSIRO Publishing
Abstract
Context: Tuberculosis is one of the major infectious diseases, with people of reproductive age group having a high risk of infection.
Aims: The present study was designed to understand the consequences of anti-tuberculosis drugs (ATDs) used in DOTS (directly observed treatment short course) schedule on ovarian function.
Methods: Adult female Swiss albino mice were orally administered with combinations of ATDs used in the DOTS schedule every day for 4 weeks. At 2 weeks after the cessation of ATDs administration, the endocrine changes and ovarian function were assessed in mice.
Key results: Administration of ATDs to mice resulted in a prolonged estrous cycle, reduced ovarian follicle reserve, alteration in FSH, LH, and progesterone level, and decreased the number of ovulated oocytes. Further, the degree of fragmentation, degeneration, abnormal distribution of cytoplasmic organelles, abnormal spindle organisation, and chromosomal misalignment were higher in oocytes that were ovulated following superovulation. Blastocysts derived from ATDs treated mice had significantly lower total cell numbers and greater DNA damage. A marginal increase in the number of resorbed fetuses was observed in all the ATDs treated groups except in the multidrug resistance treatment group. Male progeny of ATDs treated mice had decreased sperm count and lower progressive motility, while female progeny exhibited a non-significant reduction in the number of oocytes ovulated.
Conclusions: The results of this study suggest that ATDs can have significant adverse effects on the ovarian reserve, cytoplasmic organisation of oocytes, and can potentially cause transgenerational changes.
Implications: The findings of the present study indicate ovarian toxicity of ATDs and warrant further research in the direction of identifying alternate drugs with minimal toxicity, and strategies to mitigate the ovarian toxicity induced by these drugs.
Keywords: anti-tuberculosis drugs, chromosome misalignment, directly observed treatment short-course, estrous cycle, fetal resorption, mitochondrial organisation, ovarian reserve, spindle defects, tuberculosis.
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