Macrophage migration inhibitory factor modulates cytokine expression in the trophoblast cell line HTR-8/SVneo
Milica Jovanović Krivokuća
A C * , Ivana Stefanoska A * , Aleksandra Vilotić A , Danica Ćujić A , Svetlana Vrzić Petronijević B and Ljiljana Vićovac A
+ Author Affiliations
- Author Affiliations
A Laboratory for Biology of Reproduction, Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
B Clinic of Obstetrics and Gynecology, Clinical Center of Serbia, Koste Todorovića 26, 11000 Belgrade, Serbia.
C Corresponding author. Email: milicaj@inep.co.rs
Reproduction, Fertility and Development 32(18) 1326-1337 https://doi.org/10.1071/RD20138
Submitted: 27 May 2020 Accepted: 26 October 2020 Published: 16 December 2020
Abstract
Extravillous trophoblasts are specific placental cells that invade the uterine stroma and spiral arteries modifying and adjusting them to pregnancy. Many pregnancy pathologies are associated with impairment of this process, including preeclampsia and intrauterine growth restriction, among others. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is abundant at the fetomaternal interface. Previous results from our group showed that MIF participates in trophoblast invasion and modulates the expression of molecules known to mediate stromal and endovascular trophoblast invasion. In this study we investigated the possibility that MIF could act as a regulator of cytokines known to modulate trophoblast invasion using the normal extravillous trophoblast-derived cell line HTR-8/SVneo. Expression of trophoblast MIF was attenuated by MIF mRNA-specific small interfering RNAs. Cytokine expression was assessed at the mRNA and protein levels using real-time quantitative polymerase chain reaction and flow cytometry respectively. Knockdown of MIF led to a significant decrease in mRNA for IL-1β (IL1B) and IL-8 (CXCL8) and interleukin (IL)-8 protein. The addition of recombinant human MIF to cell culture medium increased IL-6 after 24 h treatment and IL-6 and IL-8 after 72 h treatment. Cell viability was not affected by MIF silencing or rhMIF treatment. The results of this study imply that at least some of the effects of MIF on trophoblast invasion could be mediated through autocrine or paracrine modulation of trophoblast cytokine production.
Keywords: cytokines, HTR-8/SVneo, macrophage migration inhibitory factor (MIF), trophoblast.
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