Effect of paracetamol treatment on maternal care and reproductive outcomes in female rat offspring

References

Agirregoitia, E., Peralta, L., Mendoza, R., Expósito, A., Ereño, E. D., Matorras, R., and Agirregoitia, N. (2012). Expression and localization of opioid receptors during the maturation of human oocytes. Reprod. Biomed. Online 24, 550–557.
| Expression and localization of opioid receptors during the maturation of human oocytes.Crossref | GoogleScholarGoogle Scholar | 22417668PubMed |

Albert, O., Desdoits-Lethimonier, C., Lesné, L., Legrand, A., Guillé, F., Bensalah, K., Dejucq-Rainsford, N., and Jégou, B. (2013). Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro. Hum. Reprod. 28, 1890–1898.
| Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro.Crossref | GoogleScholarGoogle Scholar | 23670170PubMed |

Aminoshariae, A., and Khan, A. (2015). Acetaminophen: old drug, new issues. J. Endod. , .
| Acetaminophen: old drug, new issues.Crossref | GoogleScholarGoogle Scholar | 25952187PubMed |

Anderson, B. J. (2008). Paracetamol (acetaminophen): mechanisms of action. Paediatr. Anaesth. 18, 915–921.
| Paracetamol (acetaminophen): mechanisms of action.Crossref | GoogleScholarGoogle Scholar | 18811827PubMed |

Bayne, R. A. L., Eddie, S. L., Collins, C. S., Childs, A. J., Jabbour, H. N., and Anderson, R. A. (2009). Prostaglandin E2 as a regulator of germ cells during ovarian development. J. Clin. Endocrinol. Metab. 94, 4053–4060.
| Prostaglandin E₂ as a regulator of germ cells during ovarian development.Crossref | GoogleScholarGoogle Scholar |

Beach, F. A. (1976). Prolonged hormone deprivation and pretest cage adaptation as factors affecting the display of lordosis by female rats. Physiol. Behav. 16, 807–808.
| Prolonged hormone deprivation and pretest cage adaptation as factors affecting the display of lordosis by female rats.Crossref | GoogleScholarGoogle Scholar | 981377PubMed |

Beaulac-Baillargeon, L., and Rocheleau, S. (1994). Paracetamol pharmacokinetics during the first trimester of human pregnancy. Eur. J. Clin. Pharmacol. 46, 451–454.
| Paracetamol pharmacokinetics during the first trimester of human pregnancy.Crossref | GoogleScholarGoogle Scholar | 7957542PubMed |

Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., and Leone, S. (2006). Paracetamol: new vistas of an old drug. CNS Drug Rev. 12, 250–275.
| Paracetamol: new vistas of an old drug.Crossref | GoogleScholarGoogle Scholar | 17227290PubMed |

Bhagyashree, A., Manikkoth, S., Sequeira, M., Nayak, R., and Rao, S. N. (2017). Central dopaminergic system plays a role in the analgesic action of paracetamol: preclinical evidence. Indian J. Pharmacol. 49, 21–25.
| Central dopaminergic system plays a role in the analgesic action of paracetamol: preclinical evidence.Crossref | GoogleScholarGoogle Scholar | 28458418PubMed |

Blecharz-Klin, K., Joniec-Maciejak, I., Jawna, K., Pyrzanowska, J., Piechal, A., Wawer, A., and Widy-Tyszkiewicz, E. (2015). Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata. Environ. Toxicol. Pharmacol. 40, 369–374.
| Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Crossref | GoogleScholarGoogle Scholar | 26233562PubMed |

Böttcher, B., Seeber, B., Leyendecker, G., and Wildt, L. (2017). Impact of the opioid system on the reproductive axis. Fertil. Steril. 108, 207–213.
| Impact of the opioid system on the reproductive axis.Crossref | GoogleScholarGoogle Scholar | 28669481PubMed |

Byer, A. J., and Semmer, J. R. (1982). Acetaminophen overdose in the third trimester of pregnancy. JAMA 247, 3114–3115.
| Acetaminophen overdose in the third trimester of pregnancy.Crossref | GoogleScholarGoogle Scholar | 7077806PubMed |

Cameron, N. M. (2011). Maternal programming of reproductive function and behavior in the female rat. Front. Evol. Neurosci. 3, 10.
| Maternal programming of reproductive function and behavior in the female rat.Crossref | GoogleScholarGoogle Scholar | 22203802PubMed |

Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., and Meaney, M. J. (2005). The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care. Neurosci. Biobehav. Rev. 29, 843–865.
| The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care.Crossref | GoogleScholarGoogle Scholar | 15893378PubMed |

Cameron, N., Del Corpo, A., Diorio, J., McAllister, K., Sharma, S., and Meaney, M. J. (2008a). Maternal programming of sexual behavior and hypothalamic–pituitary–gonadal function in the female rat. PLoS One 3, e2210.
| Maternal programming of sexual behavior and hypothalamic–pituitary–gonadal function in the female rat.Crossref | GoogleScholarGoogle Scholar | 18493313PubMed |

Cameron, N. M., Fish, E. W., and Meaney, M. J. (2008b). Maternal influences on the sexual behavior and reproductive success of the female rat. Horm. Behav. 54, 178–184.
| Maternal influences on the sexual behavior and reproductive success of the female rat.Crossref | GoogleScholarGoogle Scholar | 18417127PubMed |

Camin, N. A., Vieira, M. L., Montagnini, B. G., Kiss, A. C. I., and Gerardin, D. C. C. (2015). Effects of maternal exposure to the galactagogue Sulpiride on reproductive parameters in female rats. Physiol. Behav. 140, 247–253.
| Effects of maternal exposure to the galactagogue Sulpiride on reproductive parameters in female rats.Crossref | GoogleScholarGoogle Scholar |

Champagne, F. A. (2004). Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat. J. Neurosci. 24, 4113–4123.
| Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat.Crossref | GoogleScholarGoogle Scholar | 15115806PubMed |

Champagne, F. A., Francis, D. D., Mar, A., and Meaney, M. J. (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol. Behav. 79, 359–371.
| Variations in maternal care in the rat as a mediating influence for the effects of environment on development.Crossref | GoogleScholarGoogle Scholar | 12954431PubMed |

Chandrasekharan, N. V., Dai, H., Roos, K. L. T., Evanson, N. K., Tomsik, J., Elton, T. S., and Simmons, D. L. (2002). COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl Acad. Sci. USA 99, 13926–13931.
| COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.Crossref | GoogleScholarGoogle Scholar | 12242329PubMed |

Chistyakov, V. A., Dem’yanenko, S. V., Alexandrova, A. A., Gutnikova, L. V., Prokof’ev, V. N., and Kosheleva, O. N. (2012). Effect of plastoquinone derivative 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats. Biochemistry 77, 1382–1386.
| Effect of plastoquinone derivative 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats.Crossref | GoogleScholarGoogle Scholar | 23244734PubMed |

Costa, N. O., Borges, L. I., Cavalcanti, L. F., Montagnini, B. G., Anselmo Franci, J. A., Kiss, A., and Gerardin, D. (2020). In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring. J. Appl. Toxicol. 40, 504–514.
| In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring.Crossref | GoogleScholarGoogle Scholar | 31869449PubMed |

Dean, A., Van Den Driesche, S., Wang, Y., McKinnell, C., Macpherson, S., Eddie, S. L., Kinnell, H., Hurtado-Gonzalez, P., Chambers, T. J., and Stevenson, K. (2016). Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences. Sci. Rep. 6, 19789.
| Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.Crossref | GoogleScholarGoogle Scholar | 26813099PubMed |

Fent, K., Escher, C., and Caminada, D. (2006). Estrogenic activity of pharmaceuticals and pharmaceutical mixtures in a yeast reporter gene system. Reprod. Toxicol. 22, 175–185.
| Estrogenic activity of pharmaceuticals and pharmaceutical mixtures in a yeast reporter gene system.Crossref | GoogleScholarGoogle Scholar | 16781844PubMed |

Forcato, S., Montagnini, B. G., de Góes, M., da Silva Novi, D., Inhasz Kiss, A. C., Ceravolo, G. S., and Ceccatto Gerardin, D. C. (2019). Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods. Reprod. Toxicol. 87, 1–7.
| Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods.Crossref | GoogleScholarGoogle Scholar | 31055052PubMed |

Gallavan, R. H., Holson, J. F., Stump, D. G., Knapp, J. F., and Reynolds, V. L. (1999). Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights. Reprod. Toxicol. 13, 383–390.
| Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights.Crossref | GoogleScholarGoogle Scholar | 10560587PubMed |

Gan, L., Sun, M., and Chen, W. (2018). 5-Hydroxytryptamine 2A receptor inverse agonist pimavanserin impairs maternal behavior in postpartum female rats. Pharmacol. Biochem. Behav. 175, 152–159.
| 5-Hydroxytryptamine 2A receptor inverse agonist pimavanserin impairs maternal behavior in postpartum female rats.Crossref | GoogleScholarGoogle Scholar | 30393120PubMed |

Goldman, J. M., Murr, A. S., and Cooper, R. L. (2007). The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res. B Dev. Reprod. Toxicol. 80, 84–97.
| The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies.Crossref | GoogleScholarGoogle Scholar | 17342777PubMed |

Guerra, M. T., Scarano, W. R., de Toledo, F. C., Franci, J. A., and Kempinas, W. (2010). Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation. Reprod. Toxicol. 29, 99–105.
| Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation.Crossref | GoogleScholarGoogle Scholar | 19850123PubMed |

Gupta, U., Malhotra, N., Varma, S. K., and Chaudhury, R. R. (1981). Effect of intrauterine administration of antiprostaglandin drugs on implantation in the rat. Contraception 24, 283–288.
| Effect of intrauterine administration of antiprostaglandin drugs on implantation in the rat.Crossref | GoogleScholarGoogle Scholar | 7307524PubMed |

Hardy, D. F., and Debold, J. F. (1971). Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat. Physiol. Behav. 7, 643–645.
| Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat.Crossref | GoogleScholarGoogle Scholar | 5167162PubMed |

Hellstrom, I. C., Dhir, S. K., Diorio, J. C., and Meaney, M. J. (2012). Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone–serotonin–NGFI-A signalling cascade. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2495–2510.
| Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone–serotonin–NGFI-A signalling cascade.Crossref | GoogleScholarGoogle Scholar | 22826348PubMed |

Holm, J. B., Chalmey, C., Modick, H., Jensen, L. S., Dierkes, G., Weiss, T., Jensen, B. A. H., Nørregård, M. M., Borkowski, K., and Styrishave, B. (2015). Aniline is rapidly converted into paracetamol impairing male reproductive development. Toxicol. Sci. 148, 288–298.
| Aniline is rapidly converted into paracetamol impairing male reproductive development.Crossref | GoogleScholarGoogle Scholar | 26259604PubMed |

Holm, J. B., Mazaud-Guittot, S., Danneskiold-Samse, N. B., Chalmey, C., Jensen, B., Narregard, M. M., Hansen, C. H., Styrishave, B., Svingen, T., and Vinggaard, A. M. (2016). Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility. Toxicol. Sci. 150, 178–189.
| Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility.Crossref | GoogleScholarGoogle Scholar | 26732887PubMed |

Hsu, C., Liu, J., Lin, A., Yang, C., Chung, W., and Wu, W. (2014). Minoxidil may suppress androgen receptor-related functions. Oncotarget 5, 2187–2197.
| Minoxidil may suppress androgen receptor-related functions.Crossref | GoogleScholarGoogle Scholar | 24742982PubMed |

Hurtado-Gonzalez, P., Anderson, R. A., Macdonald, J., Van den Driesche, S., Kilcoyne, K., Jørgensen, A., McKinnell, C., Macpherson, S., Sharpe, R. M., and Mitchell, R. T. (2018). Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development in both sexes in rodent and human using multiple experimental systems. Environ. Health Perspect. 126, 047006.
| Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development in both sexes in rodent and human using multiple experimental systems.Crossref | GoogleScholarGoogle Scholar | 29665328PubMed |

Johansson, H. K. L., Jacobsen, P. R., Hass, U., Svingen, T., Vinggaard, A. M., Isling, L. K., Axelstad, M., Christiansen, S., and Boberg, J. (2016). Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging. Reprod. Toxicol. 61, 186–194.
| Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging.Crossref | GoogleScholarGoogle Scholar |

Johnson, A. M. (1981). Analysis of animal weight gains in chronic toxicity studies. J. Toxicol. Environ. Health 7, 307–316.
| Analysis of animal weight gains in chronic toxicity studies.Crossref | GoogleScholarGoogle Scholar | 7230278PubMed |

Jozwiak-Bebenista, M., and Nowak, J. Z. (2014). Paracetamol: mechanism of action, applications and safety concern. Acta Pol. Pharm. 71, 11–23.
| 24779190PubMed |

Kiss, A. C. I., Woodside, B., Felício, L. F., Anselmo-Franci, J., and Damasceno, D. C. (2012). Impact of maternal mild hyperglycemia on maternal care and offspring development and behavior of Wistar rats. Physiol. Behav. 107, 292–300.
| Impact of maternal mild hyperglycemia on maternal care and offspring development and behavior of Wistar rats.Crossref | GoogleScholarGoogle Scholar |

Klein, R. M., Rigobello, C., Vidigal, C. B., Moura, K. F., Barbosa, D. S., Gerardin, D., Ceravolo, G. S., and Moreira, E. G. (2020). Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny. Neurotoxicol. Teratol. 77, 106838.
| Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.Crossref | GoogleScholarGoogle Scholar | 31644948PubMed |

Kristensen, D. M., Hass, U., Lesné, L., and Lottrup, G. (2011). Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum. Reprod. 26, 235–244.
| Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.Crossref | GoogleScholarGoogle Scholar | 21059752PubMed |

Kristensen, D. M., Lesné, L., Le Fol, V., Desdoits-Lethimonier, C., Dejucq-Rainsford, N., Leffers, H., and Jégou, B. (2012). Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. Int. J. Androl. 35, 377–384.
| Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.Crossref | GoogleScholarGoogle Scholar | 22612476PubMed |

Kristensen, D. M., Mazaud-Guittot, S., Gaudriault, P., Lesné, L., Serrano, T., Main, K. M., and Jégou, B. (2016). Analgesic use – prevalence, biomonitoring and endocrine and reproductive effects. Nat. Rev. Endocrinol. , .
| Analgesic use – prevalence, biomonitoring and endocrine and reproductive effects.Crossref | GoogleScholarGoogle Scholar | 27150289PubMed |

Lind, D. V., Main, K. M., Kyhl, H. B., Kristensen, D. M., Toppari, J., Andersen, H. R., Andersen, M. S., Skakkebæk, N. E., and Jensen, T. K. (2017). Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother–child pairs. Hum. Reprod. , .
| Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother–child pairs.Crossref | GoogleScholarGoogle Scholar | 27852690PubMed |

Lopes, J., and Matheus, M. E. (2012). Risco de hepatotoxicidade do paracetamol (acetaminofem) [Risk of hepatotoxicity with acetaminophen]. Rev. Bras. Farm. 93, 411–414.

Lunger, F., Vehmas, A. P., Fürnrohr, B. G., Sopper, S., Wildt, L., and Seeber, B. (2016). Opiate receptor blockade on human granulosa cells inhibits VEGF release. Reprod. Biomed. Online 32, 316–322.
| Opiate receptor blockade on human granulosa cells inhibits VEGF release.Crossref | GoogleScholarGoogle Scholar | 26803207PubMed |

Lupattelli, A., Spigset, O., Twigg, M. J., Zagorodnikova, K., Mårdby, A. C., Moretti, M. E., Drozd, M., Panchaud, A., Hämeen-Anttila, K., and Rieutord, A. (2014). Medication use in pregnancy: a cross-sectional, multinational web-based study. BMJ Open 4, e004365.
| Medication use in pregnancy: a cross-sectional, multinational web-based study.Crossref | GoogleScholarGoogle Scholar | 24534260PubMed |

Marcondes, F. K., Biachi, F. J., and Tanno, A. P. (2002). Determination of the estrous cycle phases of rats: some helpful considerations. Braz. J. Biol. 62, 609–614.
| Determination of the estrous cycle phases of rats: some helpful considerations.Crossref | GoogleScholarGoogle Scholar | 12659010PubMed |

Mazaud-Guittot, S., Nicolaz, C. N., Desdoits-Lethimonier, C., Coiffec, I., Maamar, M., Balager, P., Kristensen, D. M., Chevrier, C., Lavoué, V., and Poulain, P. (2013). Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent. J. Clin. Endocrinol. Metab. 98, E1757–E1767.
| Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.Crossref | GoogleScholarGoogle Scholar | 24030937PubMed |

Melo, S. C. C. S., Pelloso, S. M., Carvalho, M. D. B., and Oliveira, N. L. B. (2009). Uso de medicamentos por gestantes usuárias do Sistema Único de Saúde. Acta Paul. Enferm. 22, 66–70.
| Uso de medicamentos por gestantes usuárias do Sistema Único de Saúde.Crossref | GoogleScholarGoogle Scholar |

Mitchell, A. A., Gilboa, S. M., Werler, M. M., Kelley, K. E., Louik, C., and Hernández-Díaz, S. (2011). Medication use during pregnancy, with particular focus on prescription drugs: 1976–2008. Am. J. Obstet. Gynecol. 205, 51.e1–51.e8.
| Medication use during pregnancy, with particular focus on prescription drugs: 1976–2008.Crossref | GoogleScholarGoogle Scholar |

Montagnini, B. G., Silveira, K. M., Pierone, B. C., de Azevedo Camim, N., Anselmo-Franci, J. A., de Fátima Paccola Mesquita, S., Kiss, A., and Gerardin, D. (2016). Reproductive parameters of female Wistar rats treated with methylphenidate during development. Physiol. Behav. 167, 118–124.
| Reproductive parameters of female Wistar rats treated with methylphenidate during development.Crossref | GoogleScholarGoogle Scholar | 27575975PubMed |

Montagnini, B. G., Pernoncine, K. V., Borges, L. I., Costa, N. O., Moreira, E. G., Anselmo-Franci, J. A., Kiss, A. C. I., and Gerardin, D. C. C. (2018). Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: uterotrophic assay and two-generation study. Toxicology 410, 152–165.
| Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: uterotrophic assay and two-generation study.Crossref | GoogleScholarGoogle Scholar | 30321646PubMed |

Nelson, S. M., Telfer, E. E., and Anderson, R. A. (2013). The ageing ovary and uterus: new biological insights. Hum. Reprod. Update 19, 67–83.
| The ageing ovary and uterus: new biological insights.Crossref | GoogleScholarGoogle Scholar | 23103636PubMed |

Nielsen, E., Ostergaard, G., and Larsen, J. (2008). ‘Toxicological Risk Assessment of Chemicals: A Practical Guide.’ (Informa Healthcare: New York.)

Notarianni, L. J., Oldham, H. G., and Bennett, P. N. (1987). Passage of paracetamol into breast milk and its subsequent metabolism by the neonate. Br. J. Clin. Pharmacol. 24, 63–67.
| Passage of paracetamol into breast milk and its subsequent metabolism by the neonate.Crossref | GoogleScholarGoogle Scholar | 3620287PubMed |

Numan, M. (2007). Motivational systems and the neural circuitry of maternal behaviour in the rat. Dev. Psychobiol. 49, 12–21.
| Motivational systems and the neural circuitry of maternal behaviour in the rat.Crossref | GoogleScholarGoogle Scholar | 17186513PubMed |

Organisation for Economic Co-operation and Development (OECD) (2007) ‘Test no. 426: Developmental Neurotoxicity Study.’ (OECD Publishing: Paris.) https://doi.org/10.1787/9789264067394-EN

Passoni, M. T., Nørgaard, M., Nogueira, R., Woitkowiak, C., Claudia, A., Andreotti, B., Grechi, N., Roberto, P., Hurup, C., and Styrishave, B. (2018). Assessment of the analgesic dipyrone as a possible (anti)androgenic endocrine disruptor. Toxicol. Lett. 285, 139–147.
| Assessment of the analgesic dipyrone as a possible (anti)androgenic endocrine disruptor.Crossref | GoogleScholarGoogle Scholar | 29289696PubMed |

Patel, R., and Rosengren, R. (2001). Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse. Toxicol. Lett. 122, 89–96.
| Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse.Crossref | GoogleScholarGoogle Scholar | 11397560PubMed |

Pedersen, T., and Peters, H. (1968). Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17, 555–557.
| Proposal for a classification of oocytes and follicles in the mouse ovary.Crossref | GoogleScholarGoogle Scholar | 5715685PubMed |

Petraglia, F., Segre, A., Facchinetti, F., Campanini, D., Ruspa, M., and Genazzani, A. R. (1985). Beta-endorphin and met-enkephalin in peritoneal and ovarian follicular fluids of fertile and postmenopausal women. Fertil. Steril. 44, 615–621.
| Beta-endorphin and met-enkephalin in peritoneal and ovarian follicular fluids of fertile and postmenopausal women.Crossref | GoogleScholarGoogle Scholar | 2932351PubMed |

Ramirez, O. A., Carrer, H. F., and Nasello, A. G. (1979). Prenatal amphetamine exposure: ovulation, sexual behavior and hypothalamic monoamine content in rats. Pharmacol. Biochem. Behav. 11, 605–609.
| Prenatal amphetamine exposure: ovulation, sexual behavior and hypothalamic monoamine content in rats.Crossref | GoogleScholarGoogle Scholar |

Ray-Griffith, S. L., Morrison, B., and Stowe, Z. N. (2019). Chronic pain prevalence and exposures during pregnancy. Pain Res. Manag. 2019, 6985164.
| Chronic pain prevalence and exposures during pregnancy.Crossref | GoogleScholarGoogle Scholar | 31485284PubMed |

Reis, A. R., Azevedo, M. S., Souza, M. A., Lutz, M. L., Alves, M. B., Izquierdo, I., Cammarota, M., Silveira, P. P., and Lucion, A. B. (2014). Neonatal handling alters the structure of maternal behavior and affects mother–pup bonding. Behav. Brain Res. 265, 216–228.
| Neonatal handling alters the structure of maternal behavior and affects mother–pup bonding.Crossref | GoogleScholarGoogle Scholar | 24598277PubMed |

Rice, D., and Barone, S. (2000). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ. Health Perspect. 108, 511–533.
| Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.Crossref | GoogleScholarGoogle Scholar | 10852851PubMed |

Rogers, S. M., Back, D. J., Stevenson, P. J., Grimmer, S. F., and Orme, M. L. (1987). Paracetamol interaction with oral contraceptive steroids: increased plasma concentrations of ethinyloestradiol. Br. J. Clin. Pharmacol. 23, 721–725.
| Paracetamol interaction with oral contraceptive steroids: increased plasma concentrations of ethinyloestradiol.Crossref | GoogleScholarGoogle Scholar | 3111513PubMed |

Ruggieri, V., Vitale, G., Pini, L. A., and Sandrini, M. (2008). Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl- phenolamine (AM404) in the rat: comparison with paracetamol. Naunyn Schmiedebergs Arch. Pharmacol. 377, 219–229.
| Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl- phenolamine (AM404) in the rat: comparison with paracetamol.Crossref | GoogleScholarGoogle Scholar | 18404260PubMed |

Servey, J., and Chang, J. (2014). Over-the-counter medications in pregnancy. Am. Fam. Physician 90, 548–555.
| Over-the-counter medications in pregnancy.Crossref | GoogleScholarGoogle Scholar | 25369643PubMed |

Srikiatkhachorn, A., Tarasub, N., and Govitrapong, P. (1999). Acetaminophen-induced antinociception via central 5-HT 2A receptors. Neurochem. Int. 34, 491–498.
| Acetaminophen-induced antinociception via central 5-HT 2A receptors.Crossref | GoogleScholarGoogle Scholar | 10402224PubMed |

Stolzenberg, D. S., and Numan, M. (2011). Hypothalamic interaction with the mesolimbic DA system in the control of the maternal and sexual behaviors in rats. Neurosci. Biobehav. Rev. 35, 826–847.
| Hypothalamic interaction with the mesolimbic DA system in the control of the maternal and sexual behaviors in rats.Crossref | GoogleScholarGoogle Scholar | 20955733PubMed |

Thiele, K., Kessler, T., Arck, P., Erhardt, A., and Tiegs, G. (2013). Acetaminophen and pregnancy short and long term consequences. J. Reprod. Immunol. 97, 128–139.
| Acetaminophen and pregnancy short and long term consequences.Crossref | GoogleScholarGoogle Scholar | 23432879PubMed |

United States Environmental Protection Agency (2011). Recommended use of body weight 3/4 as the default method in derivation of the oral reference dose. 100-R11-00. Available at https://www.epa.gov/risk/recommended-use-body-weight-34-default-method-derivation-oral-reference-dose [verified 19 November 2020].

U.S. Food and Drug Administration (FDA) (2015). FDA drug safety communication: FDA has reviewed possible risks of pain medicine use during pregnancy. Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-has-reviewed-possible-risks-pain-medicine-use-during-pregnancy [verified 19 November 2020].

van den Driesche, S., Macdonald, J., Anderson, R. A., Johnston, Z. C., Chetty, T., Smith, L. B., Mckinnell, C., Dean, A., Homer, N. Z., and Jorgensen, A. (2015). Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model. Sci. Transl. Med. 7, 288ra80.
| Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.Crossref | GoogleScholarGoogle Scholar | 25995226PubMed |

Walker, C. D., Deschamps, S., Proulx, K., Tu, M., Salzman, C., Woodside, B., Lupien, S., Gallo-Payet, N., and Richard, D. (2004). Mother to infant or infant to mother? Reciprocal regulation of responsiveness to stress in rodents and the implications for humans. J. Psychiatry Neurosci. 29, 364–382.
| 15486606PubMed |

Wangikar, P., Ahmed, T., and Vengala, S. (2011). Toxicologic pathology of reproductive system. In ‘Reproductive and Developmental Toxicology’. (Ed. R. Gupta). pp. 1003–1026. (Elsevier.)

Werler, M. M., Mitchell, A. A., Hernandez-Diaz, S., and Honein, M. A. (2005). Use of over-the-counter medications during pregnancy. Am. J. Obstet. Gynecol. 193, 771–777.
| Use of over-the-counter medications during pregnancy.Crossref | GoogleScholarGoogle Scholar | 16150273PubMed |