Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)
Leopoldina Scotti A D , Dalhia Abramovich A , Natalia Pascuali A , Luis Haro Durand A , Griselda Irusta A , Ignacio de Zúñiga B , Marta Tesone A C and Fernanda Parborell A
+ Author Affiliations
- Author Affiliations
A Instituto de Biología y Medicina Experimental (IByME) – CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina.
B Centro Médico PREGNA Medicina Reproductiva, Juncal 3490 (1425) Buenos Aires, Argentina.
C Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales – Universidad de Buenos Aires, Intendente Güiraldes 2160 (1428), Buenos Aires, Argentina.
D Corresponding author. Email: leopoldinascotti@gmail.com
Reproduction, Fertility and Development 28(6) 690-699 https://doi.org/10.1071/RD13356
Submitted: 22 October 2013 Accepted: 11 September 2014 Published: 11 November 2014
Abstract
Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with gonadotrophins following human chorionic gonadotrophin (hCG) administration. The relationship between hCG and OHSS is partly mediated via the production of angiogenic factors, such as vascular endothelial growth factor A (VEGFA) and angiopoietins (ANGPTs). Here, we investigated the effect of ANGPT1 inhibition on ovarian angiogenesis in follicular fluid (FF) from women at risk of OHSS, using the chorioallantoic membrane (CAM) of quail embryos as an experimental model. We also analysed cytoskeletal changes and endothelial junction protein expression induced by this FF in the presence or absence of an ANGPT1-neutralising antibody in endothelial cell cultures. The presence of this antibody restored the number of vascular branch points and integrin αvβ3 levels in the CAMs to control values. ANGPT1 inhibition in FF from OHSS patients also restored the levels of claudin-5, vascular endothelial cadherin and phosphorylated β-catenin and partially reversed actin redistribution in endothelial cells. Our findings suggest that ANGPT1 increases pathophysiological angiogenesis in patients at risk of OHSS by acting on tight and adherens junction proteins. Elucidating the mechanisms by which ANGPT1 regulates vascular development and cell–cell junctions in OHSS will contribute to identifying new therapeutic targets for the treatment of human diseases with aberrant vascular leakage.
Additional keywords: angiogenesis, follicular fluid, ovary, reproduction.
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