β1 and β3 integrins disassemble from basal focal adhesions and β3 integrin is later localised to the apical plasma membrane of rat uterine luminal epithelial cells at the time of implantation
Yui Kaneko A C , Laura Lecce A , Margot L. Day B and Christopher R. Murphy A
+ Author Affiliations
- Author Affiliations
A School of Medical Sciences (Discipline of Anatomy and Histology) and The Bosch Institute, Anderson Stuart Building, The University of Sydney, Sydney, NSW 2006, Australia.
B School of Medical Sciences (Discipline of Physiology) and The Bosch Institute, The Medical Foundation Building, The University of Sydney, Sydney, NSW 2050, Australia.
C Corresponding author. Email: ykan0009@anatomy.usyd.edu.au
Reproduction, Fertility and Development 23(3) 481-495 https://doi.org/10.1071/RD10211
Submitted: 1 September 2010 Accepted: 27 October 2010 Published: 16 March 2011
Abstract
The present study investigated the expression of integrin subunits that are known to be associated with focal adhesions, namely β1 and β3 integrins in rat uterine luminal epithelial cells during early pregnancy. The β1 and β3 integrins were concentrated along the basal cell surface and were colocalised and structurally interacted with talin, a principal focal adhesion protein, on Day 1 of pregnancy. At the time of implantation, β1 and β3 integrins disassembled from the site of focal adhesions, facilitating the removal of uterine luminal epithelial cells for embryo invasion. Also at this time, β3 integrin markedly increased along the apical membrane, suggesting a role in embryo attachment. This distributional change in β1 and β3 integrins seen at the time of implantation was predominantly under the influence of progesterone. Taken together, β1 and β3 integrin disassembly from focal adhesions and the increase in β3 integrin apically are key components of hormonally regulated endometrial receptivity.
Additional keyword: ovarian hormones.
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