Register      Login
Microbiology Australia Microbiology Australia Society
Microbiology Australia, bringing Microbiologists together
RESEARCH ARTICLE

The 1918 Spanish influenza pandemic: plus ça change, plus c’est la même chose

Paul Selleck A C and Ross Barnard B D
+ Author Affiliations
- Author Affiliations

A CSIRO Australian Centre for Disease Preparedness, Private Bag 24, Geelong, Vic., 3220, Australia

B School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, and ARC Training Centre for Biopharmaceutical Innovation, The University of Queensland Brisbane, Qld 4072, Australia

C Tel.: +61 3 5227 5000 Fax.: +61 3 5227 5555 Email: Paul.Selleck@csiro.au

D Tel.: +61 4 1049 4472 Fax: +61 7 3365 4299 Email: rossbarnard@uq.edu.au

Microbiology Australia 41(4) 177-182 https://doi.org/10.1071/MA20049
Published: 7 October 2020

Abstract

Towards the end of world war one, the world faced a pandemic, caused not by smallpox or bubonic plague, but by an influenza A virus. The 1918–19 influenza pandemic was possibly the worst single natural disaster of all time, infecting an estimated 500 million people, or one third of the world population and killing between 20 and 100 million people in just over one year. The impact of the virus may have influenced the outcome of the first world war and killed more people than the war itself. The pandemic resulted in global economic disruption. It was a stimulus to establishment of local vaccine production in Australia. Those cities that removed public health restrictions too early experienced a second wave of infections. Unfortunately, it seems that the lessons of infection control and epidemic preparedness must be relearnt in every generation and for each new epidemic.


References

[1]  Huf, B. and Mclean, H. (2000) Epidemics and pandemics in Victoria: historical perspectives. Research Paper No. 1, May 2020. Research & Inquiries Unit, Parliamentary Library & Information Service.

[2]  Short, K.R. et al. (2018) Back to the future: lessons learned from the 1918 influenza pandemic. Front. Cell. Infect. Microbiol. 8, 343.
Back to the future: lessons learned from the 1918 influenza pandemic.Crossref | GoogleScholarGoogle Scholar | 30349811PubMed |

[3]  Taubenberger, J.K. (2006) The origin and virulence of the 1918 ‘Spanish’ influenza virus. Proc. Am. Philos. Soc. 150, 86–112.
| 17526158PubMed |

[4]  Taubenberger, J.K. and Morens, D.M. (2006) 1918 influenza: the mother of all pandemics. Emerg. Infect. Dis. 12, 15–22.
1918 influenza: the mother of all pandemics.Crossref | GoogleScholarGoogle Scholar | 16494711PubMed |

[5]  Kilbourne, E.D. (2009) Commentary on fatalities in the 1918–1919 influenza pandemic. J. Infect. Dis. 199, 913.
Commentary on fatalities in the 1918–1919 influenza pandemic.Crossref | GoogleScholarGoogle Scholar | 19239341PubMed |

[6]  Ludendorff, E. (1919) Meine Kriegserinnerungen 1914–1918. Berlin: Ernst Siegfried Mittler und Sohn Verlagsbuchhandlung; p. 514.

[7]  Taubenberger, J.K. et al. (2005) Characterization of the 1918 influenza virus polymerase genes. Nature 437, 889–893.
Characterization of the 1918 influenza virus polymerase genes.Crossref | GoogleScholarGoogle Scholar | 16208372PubMed |

[8]  Gibbs, M.J. and Gibbs, A.J. (2006) Was the 1918 pandemic caused by a bird flu? Nature 440, E8.
Was the 1918 pandemic caused by a bird flu?Crossref | GoogleScholarGoogle Scholar | 16641948PubMed |

[9]  Antonovics, J. et al. (2006) Was the 1918 flu avian in origin? Nature 440, E9.
Was the 1918 flu avian in origin?Crossref | GoogleScholarGoogle Scholar | 16641950PubMed |

[10]  Morison, P. (2019) The Martin Spirit. Halstead Press, Braddon, ACT, Australia.

[11]  Taubenberger, J.K. et al. (1997) Initial genetic characterization of the 1918 “Spanish” influenza virus. Science 275, 1793–1796.
Initial genetic characterization of the 1918 “Spanish” influenza virus.Crossref | GoogleScholarGoogle Scholar | 9065404PubMed |

[12]  Davies, P. (1999) Catching Cold. Michael Joseph, Penguin Books Ltd, Harmondsworth, Middlesex, UK.

[13]  Curson, P. and McCracken, K. (2006) An Australian perspective of the 1918–1919 influenza pandemic. N S W Public Health Bull. 17, 103–107.
An Australian perspective of the 1918–1919 influenza pandemic.Crossref | GoogleScholarGoogle Scholar | 17136138PubMed |

[14]  McQueen, H. (1976) The ‘Spanish’ influenza pandemic in Australia, 1918–19. In Social Policy in Australia – Some Perspectives 1901–1975 (J. Roe, ed.). Cassell, Sydney, NSW, Australia.

[15]  Barberis, I. et al. (2016) History and evolution of influenza control through vaccination: from the first monovalent to universal vaccines. J. Prev. Med. Hyg. 57, E115–E120.
| 27980374PubMed |

[16]  Fenner, F. (ed.) (1990) History of Microbiology in Australia. Brolga Press, Curtin, ACT, Australia.

[17]  Burnett, F.M. (1940) Influenza virus infection of the chick embryo lung. Br. J. Exp. Pathol. 21, 147–153.

[18]  Strochlic, N. and Champine, R.D. (2020) How some cities ‘flattened the curve’ during the 1918 pandemic. National Geographic 27 March.

[19]  Markel, H. et al. (2007) Nonpharmaceutical interventions implemented by US cities during the 1918–1919 influenza pandemic. JAMA 298, 644–654.
Nonpharmaceutical interventions implemented by US cities during the 1918–1919 influenza pandemic.Crossref | GoogleScholarGoogle Scholar | 17684187PubMed |

[20]  Hatchett, R.J. et al. (2007) Public health interventions and epidemic intensity during the 1918 influenza pandemic. Proc. Natl. Acad. Sci. USA 104, 7582–7587.
Public health interventions and epidemic intensity during the 1918 influenza pandemic.Crossref | GoogleScholarGoogle Scholar | 17416679PubMed |

[21]  Bootsma, M.C.J. and Ferguson, N.M. (2007) The effect of public health measures on the 1918 influenza pandemic in U.S. cities. Proc. Natl. Acad. Sci. USA 104, 7588–7593.
The effect of public health measures on the 1918 influenza pandemic in U.S. cities.Crossref | GoogleScholarGoogle Scholar |

[22]  Pregelj, L. et al. (2020) Working hard or hardly working? Regulatory bottlenecks in developing a COVID-19 vaccine. Trends Biotechnol. , .
Working hard or hardly working? Regulatory bottlenecks in developing a COVID-19 vaccine.Crossref | GoogleScholarGoogle Scholar | 32600777PubMed |

[23]  http://www.influenzacentre.org (accessed 12 August 2020).

[24]  Garrett, T.A. (2008) Pandemic economics: the 1918 influenza and its modern-day implications . Federal Reserve Bank of St Louis Review 90, 75–93.

[25]  Barro, R.J. et al. (2020) The coronavirus and the great influenza pandemic: lessons from the “Spanish flu” for the coronavirus’s potential effects on mortality and economic activity. NBER working paper no. 26866. National Bureau of Economic Research, Cambridge, MA, USA. http://www.nber.org/papers/26866