Register      Login
Microbiology Australia Microbiology Australia Society
Microbiology Australia, bringing Microbiologists together
RESEARCH ARTICLE

The global eradication of smallpox and the work of Frank Fenner

CR Robert George A and William Rawlinson A
+ Author Affiliations
- Author Affiliations

Virology Division, SEALS Microbiology
Prince of Wales Hospital
Randwick, NSW 2031, Australia
Email: w.rawlinson@unsw.edu.au

Microbiology Australia 35(3) 165-168 https://doi.org/10.1071/MA14043
Published: 26 August 2014

Abstract

The 1950s and 1960s represented a golden era in scientific discovery when many believed science would solve the world's greatest problems. It was the era when colour television was introduced and the role of DNA described, space programmes, the introduction of vaccines for polio, measles and mumps, and the structures of proteins began to be described. Many discoveries were controversial, but there was a strong belief science was taking the world forward and reducing medical problems rapidly. The Intensified Smallpox Eradication Program (ISEP) won united support from both the Union of Soviet Socialist Republics (USSR) and the United States of America (USA). The initiative was passed by only a small margin (two votes) and came on the back of several failed disease eradication programmes1.


References

[1]  Fenner, F. et al. (1988) Smallpox and its eradication. Geneva: World Health Organization.

[2]  Wilks, C.R. and Studdert, M.J. (2011) Frank Fenner: 1914–2010. Aust. Vet. J. 89, 81.
Frank Fenner: 1914–2010.Crossref | GoogleScholarGoogle Scholar |

[3]  Murphy, F.A. (2011) In memoriam: Frank John Fenner (1914–2010). Emerg. Infect. Dis. 17, 759–762.
In memoriam: Frank John Fenner (1914–2010).Crossref | GoogleScholarGoogle Scholar | 21470486PubMed |

[4]  Murphy, F.A. (2011) In memoriam: Frank John Fenner (1914–2010). Arch. Virol. 156, 363–367.
In memoriam: Frank John Fenner (1914–2010).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtleisLk%3D&md5=50acc0bdf500b991ac748924b7572d7cCAS | 21221675PubMed |

[5]  Lessi, A. (2011) Obituary: Professor Frank Fenner (1914–2010). N S W Public Health Bull. 22, 33.
Obituary: Professor Frank Fenner (1914–2010).Crossref | GoogleScholarGoogle Scholar |

[6]  Hodgkin, P.D. (2011) Remembering Frank Fenner. Immunol. Cell Biol. 89, 497–498.
Remembering Frank Fenner.Crossref | GoogleScholarGoogle Scholar |

[7]  Henderson, D.A. (2011) Frank Fenner (1914–2010). Nature 469, 35.
Frank Fenner (1914–2010).Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXitl2rsw%3D%3D&md5=c33b4274bd6f83944ccbf73e7ecdb63dCAS | 21209651PubMed |

[8]  Sweet, M. (2010) Frank Fenner: helped eradicate smallpox. BMJ 341, 1218.

[9]  Pincock, S. (2011) Frank John Fenner. Lancet 377, 24.
Frank John Fenner.Crossref | GoogleScholarGoogle Scholar |

[10]  Brett-Crowther, M. (2011) Frank Fenner, AC, CMG, MBE, FAA, FRS. Int. J. Environ. Stud. 68, 141–143.
Frank Fenner, AC, CMG, MBE, FAA, FRS.Crossref | GoogleScholarGoogle Scholar |

[11]  Breman, J.G. and Henderson, D.A. (2002) Diagnosis and management of smallpox. N. Engl. J. Med. 346, 1300–1308.
Diagnosis and management of smallpox.Crossref | GoogleScholarGoogle Scholar | 11923491PubMed |

[12]  Brooks, F.J. (1993) Revising the Conquest of Mexico: smallpox, sources, and populations. J. Interdiscip. Hist. 24, 1–29.
Revising the Conquest of Mexico: smallpox, sources, and populations.Crossref | GoogleScholarGoogle Scholar |

[13]  King, R. (1850) Address to the Ethnological Society of London delivered at the anniversary, 25th May 1844. Journal of the Ethnological Society of London (1848–1856) 2, 9–42.

[14]  Bennett, M.J. (2009) Smallpox and cowpox under the Southern Cross: the smallpox epidemic of 1789 and the advent of vaccination in colonial Australia. Bull. Hist. Med. 83, 37–62.
Smallpox and cowpox under the Southern Cross: the smallpox epidemic of 1789 and the advent of vaccination in colonial Australia.Crossref | GoogleScholarGoogle Scholar | 19329841PubMed |

[15]  Irwin, F. (1910) Smallpox in Japan. Public Health Reports (1896–1970) 25, 1205–1208.

[16]  Haygarth, J. (1793) A sketch of a plan to exterminate the casual small-pox: from Great Britain; and to introduce general inoculation: to which is added, a correspondence on the nature of variolous contagion... London: J. Johnson.

[17]  Jenner, E. (1801) On the origin of the vaccine inoculation. London: D. N. Shury.

[18]  Nelson, A.M. (1999) The cost of disease eradication. Smallpox and bovine tuberculosis. Ann. N. Y. Acad. Sci. 894, 83–91.
The cost of disease eradication. Smallpox and bovine tuberculosis.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c7ks1Gmtw%3D%3D&md5=50e915d3982fd768d050d081c0777d33CAS | 10681974PubMed |

[19]  Henderson, D.A. (1987) Principles and lessons from the smallpox eradication programme. Bull. World Health Organ. 65, 535–546.
| 1:STN:280:DyaL1c%2FotVOrsQ%3D%3D&md5=b2f362708125ac9c94165b3d00da5044CAS | 3319270PubMed |

[20]  Henderson, D.A. and Klepac, P. (2013) Lessons from the eradication of smallpox: an interview with D. A. Henderson. Philos. Trans. R. Soc. Lond. B Biol. Sci. 368, 20130113.
Lessons from the eradication of smallpox: an interview with D. A. Henderson.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3sjls1Cruw%3D%3D&md5=883d74ec793fa7346b67456649f00d06CAS | 23798700PubMed |

[21]  Strassburg, M.A. (1982) The global eradication of smallpox. Am. J. Infect. Control 10, 53–59.
The global eradication of smallpox.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL383gsVemtg%3D%3D&md5=33eab6b9fbddb98885870510777cd7ebCAS | 7044193PubMed |

[22]  World Health Organization (1978) SME/78.3: Plan of action for the smallpox eradication programme in Somalia 1978/1979. World Health Organization.

[23]  World Health Organization (1977) Smallpox surveillance. Wkly. Epidemiol. Rec. 52, 389–396.

[24]  Breman, J.G. and Arita, I. (1980) The confirmation and maintenance of smallpox eradication. N. Engl. J. Med. 303, 1263–1273.
The confirmation and maintenance of smallpox eradication.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL3M%2FjtVOqsA%3D%3D&md5=3ffbd67204a2ce58f40c6605592842c3CAS | 6252467PubMed |

[25]  Berche, P. (2001) The threat of smallpox and bioterrorism. Trends Microbiol. 9, 15–18.
The threat of smallpox and bioterrorism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXlvFemsLk%3D&md5=526a86a0ee9d71601155f3af8211cf61CAS | 11166237PubMed |

[26]  Tucker, J.B (2011) Breaking the deadlock over destruction of the smallpox virus stocks. Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science 9, 55–67.

[27]  Cohen, H.W. et al. (2004) The pitfalls of bioterrorism preparedness: the anthrax and smallpox experiences. Am. J. Public Health 94, 1667–1671.
The pitfalls of bioterrorism preparedness: the anthrax and smallpox experiences.Crossref | GoogleScholarGoogle Scholar | 15451727PubMed |

[28]  Arness, M.K. et al. (2004) Myopericarditis following smallpox vaccination. Am. J. Epidemiol. 160, 642–651.
Myopericarditis following smallpox vaccination.Crossref | GoogleScholarGoogle Scholar | 15383408PubMed |

[29]  Halsell, J.S. et al. (2003) Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel. JAMA 289, 3283–3289.
Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel.Crossref | GoogleScholarGoogle Scholar | 12824210PubMed |

[30]  Cohen, J. (2014) Lab safety. Alarm over biosafety blunders. Science 345, 247–248.
Lab safety. Alarm over biosafety blunders.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtlagt77E&md5=421acbf627fc9361eabe145e1632b308CAS | 25035464PubMed |

[31]  McCarthy, M. (2014) Smallpox samples are found in FDA storage room in Maryland. BMJ 349, g4545.
Smallpox samples are found in FDA storage room in Maryland.Crossref | GoogleScholarGoogle Scholar | 25013209PubMed |