Peptic ulcer disease: current notions
Natalia Castaño-Rodríguez and Hazel M Mitchell
+ Author Affiliations
- Author Affiliations
School of Biotechnology and Biomolecular Sciences
The University of New South Wales
Sydney, NSW 2052, Australia
Tel: +61 2 9385 2040
Fax: +61 2 9385 1483
Email: h.mitchell@unsw.edu.au
Microbiology Australia 34(3) 147-150 https://doi.org/10.1071/MA13049
Published: 4 September 2013
Abstract
Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) are the major aetiological factors in peptic ulcer disease (PUD). A range of H. pylori virulence factors have been linked with both increased levels of inflammation and PUD. Recently, increasing reports of H. pylori-negative PUD has led some to question the role of H. pylori in PUD; however, research would suggest that H. pylori-negative PUDs are mainly due to NSAIDs usage and false negative results in diagnostic methods.
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