Movement of resistance genes in hospitals

Sally R Partridge

doi:10.1071/MA14017

RESEARCH ARTICLE

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Movement of resistance genes in hospitals

Sally R Partridge

+ Author Affiliations

- Author Affiliations

Centre for Infectious Diseases and Microbiology
University of Sydney

Westmead Millennium Institute
Westmead Hospital
Westmead, NSW 2145, Australia
Tel: +61 2 9845 5246
Fax: +61 2 9891 5317
Email: sally.partridge@health.nsw.gov.au

Microbiology Australia 35(1) 60-62 https://doi.org/10.1071/MA14017
Published: 4 February 2014

Abstract

Enterobactericeae resistant to multiple antibiotics are an increasing global health problem that impacts treatment and survival of hospitalised patients. In these organisms much of the antibiotic resistance is due to a wide variety of ‘mobile' resistance genes that have been captured from the chromosomes of different bacterial species and transferred to plasmids by the actions of various mobile genetic elements. These plasmids can then spread between bacterial cells, including different species. The association of resistance genes with mobile elements, these mobile elements with plasmids and plasmids with particular bacterial strains means that spread of resistance genes can occur at several different levels (Figure 1). Understanding more about the contributions of these different processes and how they interact may enable better prediction and control of the spread of resistance.

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