“Gone in the back legs”
Richard Malik A , Derek Spielman B and Jan Šlapeta BA Centre for Veterinary Education
The University of Sydney,
NSW 2006, Australia
B Faculty of Veterinary Science,
The University of Sydney,
NSW 2006, Australia
Microbiology Australia 34(1) 8-12 https://doi.org/10.1071/MA13004
Published: 20 March 2013
Abstract
Neural angiostrongyliasis and neosporosis are the two most common infectious causes of spinal cord disease in young dogs. The former is caused by migration of Angiostrongylus cantonensis (rat lungworm) larvae following ingestion of mollusc intermediate hosts, while the latter is caused by the apicomplexan protozoan Neospora caninum, acquired transplacentally, during parturition or in the neonatal period. This article gives the reader the perspective of a veterinarian confronted with the diagnosis and treatment of these two potentially life-threatening infections, taking into account differences in epidemiology and pathogenesis, and listing diagnostic tests available and affordable for most owners. The broader implications of these infections for other species, including people and wildlife, are discussed.
References
[1] Mason, K.V. (1987) Canine neural angiostrongyliasis: the clinical and therapeutic features of 55 natural cases. Aust. Vet. J. 64, 201–203.| Canine neural angiostrongyliasis: the clinical and therapeutic features of 55 natural cases.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL1c%2FkvFektA%3D%3D&md5=ccc2d1fb0d4922cc86ace720e86cbe97CAS |
[2] Mason, K.V. et al. (1976) Granulomatous encephalomyelitis of puppies due to Angiostrongylus cantonensis. Aust. Vet. J. 52, 295.
| Granulomatous encephalomyelitis of puppies due to Angiostrongylus cantonensis.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaE2s%2FitFagsQ%3D%3D&md5=f10e8a2a3179de9e3a137229786acd8cCAS |
[3] Collins, G.H. et al. (1992) Angiostronglyosis in dogs in Sydney. Aust. Vet. J. 69, 170–171.
| Angiostronglyosis in dogs in Sydney.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3s%2FnsVyntA%3D%3D&md5=7e252988bdcbab49233fcee92402fdb8CAS |
[4] Lunn, J. et al. (2003) Antemortem diagnosis of canine neural angiostronglyosis using ELISA. Aust. Vet. J. 81, 128–131.
| Antemortem diagnosis of canine neural angiostronglyosis using ELISA.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2c7osVCgtA%3D%3D&md5=72c3cdd87ce87f16a2b3805ac46fb070CAS |
[5] Lunn, J. et al. (2012) Twenty two cases of canine neural angiostronglyosis in eastern Australia (2002–2005) and a review of the literature. Parasites Vectors 5, 70.
| Twenty two cases of canine neural angiostronglyosis in eastern Australia (2002–2005) and a review of the literature.Crossref | GoogleScholarGoogle Scholar |
[6] Dubey, J.P. et al. (2007) Epidemiology and control of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 20, 323–367.
| Epidemiology and control of neosporosis and Neospora caninum.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2s3itVajsg%3D%3D&md5=60f67810ba8322ccaf6cd00f3b480947CAS |
[7] Reichel, M.P. et al. (2007) Neosporosis and hammondiosis in dogs. J. Small Anim. Pract. 48, 308–312.
| Neosporosis and hammondiosis in dogs.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD2szjsFOqsg%3D%3D&md5=c88f837544559155e51fee2b9c03e617CAS |
[8] King, J.S. et al. (2010) Australian dingoes are definitive hosts of Neospora caninum. Int. J. Parasitol. 40, 945–950.
| Australian dingoes are definitive hosts of Neospora caninum.Crossref | GoogleScholarGoogle Scholar |
[9] King, J.S. et al. (2012) Oocysts and high seroprevalence of Neospora caninum in dogs living in remote Aboriginal communities and wild dogs in Australia. Vet. Parasitol. 187, 85–92.
| Oocysts and high seroprevalence of Neospora caninum in dogs living in remote Aboriginal communities and wild dogs in Australia.Crossref | GoogleScholarGoogle Scholar |
[10] King, J.S. et al. (2011) Implications of wild dog ecology on the sylvatic and domestic life cycle of Neospora caninum in Australia. Vet. J. 188, 24–33.
| Implications of wild dog ecology on the sylvatic and domestic life cycle of Neospora caninum in Australia.Crossref | GoogleScholarGoogle Scholar |
[11] Reid, A.J. et al. (2012) Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathog. 8, e1002567.
| Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XltVymu74%3D&md5=c9ea8f5cc48e0d0e82e9269d594c980cCAS |
[12] Cooke-Yarborough, C.M. et al. (1999) A fatal case of angiostronglyosis in an 11-month-old infant. Med. J. Aust. 170, 541–543.
| 1:STN:280:DyaK1MzisFelug%3D%3D&md5=06c19d5879151b1cc950ecc8ec3453f3CAS |
[13] Senanayake, S.N. et al. (2003) First report of human angiostrongyliasis reported in Sydney. Med. J. Aust. 179, 430–431.
[14] Hsieh, T. et al. (2001) Magnetic resonance imaging findings of eosinophilic meningoencephalitis caused by angiostronglyosis. Zhonghua Fang She Xue Za Zhi 26, 45–49.
[15] Yong, W.K. et al. (1981) Localized distribution of A. cantonensis among wild rat populations in Brisbane, Australia. S.E.A. J. Trop. Med. Pub. Hlth. 12, 608–609.
| 1:STN:280:DyaL383isVWhtQ%3D%3D&md5=18674729a2bc52493fb58cbbbdf6bf54CAS |
[16] Stokes, V.L.D. et al. (2007) Occurrence of Angiostrongylus species (Nematoda) in populations of Rattus rattus and Rattus fuscipes in coastal forests of south-eastern Australia. Aust. J. Zool. 55, 177–184.
| Occurrence of Angiostrongylus species (Nematoda) in populations of Rattus rattus and Rattus fuscipes in coastal forests of south-eastern Australia.Crossref | GoogleScholarGoogle Scholar |
[17] Daft, B.M. et al. (2002) Sensitivity and specificity of western blot testing of cerebrospinal fluid and serum for diagnosis of equine protozoal myeloencephalitis in horses with and without neurologic abnormalities. J. Am. Vet. Med. Assoc. 221, 1007–1013.
| Sensitivity and specificity of western blot testing of cerebrospinal fluid and serum for diagnosis of equine protozoal myeloencephalitis in horses with and without neurologic abnormalities.Crossref | GoogleScholarGoogle Scholar |
[18] Furr, M. et al. (2001) Efficacy of ponazuril 15% oral paste as a treatment for equine protozoal myeloencephalitis. Vet. Ther. 2, 215–222.
| 1:STN:280:DC%2BD1MnhvVyjtw%3D%3D&md5=a29e3638a262e548107738297235abe9CAS |
[19] Chotmongkol, V. and Sawanyawisuth, K. (2002) Clinical manifestations and outcome of patients with severe eosinophilic meningoencephalitis presumably caused by Angiostrongylus cantonensis. S.E.A. J. Trop. Med. Pub. Health 33, 231–234.
[20] Britton, P. et al. (2011) Paediatric angiostrongyliasis – two severe concurrent cases from Sydney, Australia. Proceedings of the 7th World Congress of the World Society for Pediatric Infectious Diseases, Melbourne, Australia.
[21] Wright, J.D. (1991) Equine neural angiostronglyosis. Aust. Vet. J. 68, 58–60.
| Equine neural angiostronglyosis.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3M3it1Sluw%3D%3D&md5=22b211c038d726fd9cc77a9fd110fe59CAS |
[22] Higgins, D.P. et al. (1997) Neural angiostronglyosis in three captive rufous bettongs (Aepyprymnus rufescens). Aust. Vet. J. 75, 564–566.
| Neural angiostronglyosis in three captive rufous bettongs (Aepyprymnus rufescens).Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2svjvVyluw%3D%3D&md5=6fa9f062c7fb8e7d7c3f079b07885e7cCAS |
[23] Carlisle, M.S. et al. (1998) Cerebrospinal angiostronglyosis in five captive tamarins (Sanguinus spp). Aust. Vet. J. 76, 167–170.
| Cerebrospinal angiostronglyosis in five captive tamarins (Sanguinus spp).Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1c3jvFyqug%3D%3D&md5=1fc917b8d7a895d5c3472192113b1930CAS |
[24] Barrett, J.L. et al. (2002) Neuro-angiostrongylosis in wild Black and Grey-headed flying foxes (Pteropus spp). Aust. Vet. J. 80, 554–558.
| Neuro-angiostrongylosis in wild Black and Grey-headed flying foxes (Pteropus spp).Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD38njvVOisw%3D%3D&md5=0325917c03819d21cf2314f84dfef662CAS |
[25] Ma, G. et al. (2013) Tawny frogmouths and brushtail possums as sentinels for Angiostrongylus cantonensis, the rat lungworm. Vet. Parasitol. , .
| Tawny frogmouths and brushtail possums as sentinels for Angiostrongylus cantonensis, the rat lungworm.Crossref | GoogleScholarGoogle Scholar |
[26] Gelis, S. et al. (2011) Neuroangiostrongyliasis and other parasites in tawny frogmouths (Podargus strigoides) in south-eastern Queensland. Aust. Vet. J. 89, 47–50.
| Neuroangiostrongyliasis and other parasites in tawny frogmouths (Podargus strigoides) in south-eastern Queensland.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3M7otVCltQ%3D%3D&md5=d513398e797f3a269a52680cc789df53CAS |
[27] Bishop, S. et al. (2010) The first report of ovine cerebral neosporosis and evaluation of Neospora caninum prevalence in sheep in New South Wales. Vet. Parasitol. 170, 137–142.
| The first report of ovine cerebral neosporosis and evaluation of Neospora caninum prevalence in sheep in New South Wales.Crossref | GoogleScholarGoogle Scholar |
[28] Sangster, C. et al. (2010) Neosporosis in an aborted Southern White Rhinoceros (Ceratotherium simum simum) foetus. J. Wildlife Zoo Med. 41, 725–728.
| Neosporosis in an aborted Southern White Rhinoceros (Ceratotherium simum simum) foetus.Crossref | GoogleScholarGoogle Scholar |
[29] King, J.S. et al. (2011) Extensive production of Neospora caninum tissue cysts in a carnivorous marsupial succumbing to experimental neosporosis. Vet. Res. 42, 75.
| Extensive production of Neospora caninum tissue cysts in a carnivorous marsupial succumbing to experimental neosporosis.Crossref | GoogleScholarGoogle Scholar |